CD98 Antibody (1C11.7E3)

Images

 
Western Blot: CD98 Antibody (1C11.7E3) [NBP2-36491] - Western blot analysis of human CD98 in recombinant protein, A431, Jurkat, HeLa and HepG2 lysates at 2.0 ug/ml.
Immunohistochemistry-Paraffin: CD98 Antibody (1C11.7E3) [NBP2-36491] - IHC analysis of formalin-fixed paraffin-embedded tissue section of human kidney using CD98 antibody (clone 1C11.7E3) at 1:300 dilution. The antibody ...read more
Flow (Cell Surface): CD98 Antibody (1C11.7E3) [NBP2-36491] - Flow cytometry analysis of human CD98 in hPBMC. Primary antibody was used at 2.5 ug / million cells. Goat anti-mouse IgG (PE) was used at 0.5 ug / million ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, Flow-CS, IHC, IHC-P
Clone
1C11.7E3
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

CD98 Antibody (1C11.7E3) Summary

Immunogen
Partial recominant human CD98 (between amino acids 200-400) [UniProt P08195]
Localization
Single-pass transmembrane protein with extracellular, helical and cytoplasmic domains.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
SLC3A2
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 ug / ml
  • Flow Cytometry 2.5 ug / million cells
  • Immunohistochemistry 1:200 - 1:1000
  • Immunohistochemistry-Paraffin 1:200 - 1:1000
  • Flow (Cell Surface)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for CD98 Antibody (1C11.7E3)

  • 4F2
  • 4F2hc
  • 4T2HC
  • antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43,4F2HC
  • CD98 antigen
  • CD98 heavy chain
  • CD98
  • CD98HC
  • CH98hc
  • FRP-1
  • heavy chain
  • Lymphocyte activation antigen 4F2 large subunit
  • MDU1antigen defined by monoclonal 4F2, heavy chain
  • monoclonal 44D7
  • NACAE4F2 cell-surface antigen heavy chain
  • SLC3A2
  • solute carrier family 3 (activators of dibasic and neutral amino acidtransport), member 2,4F2 heavy chain antigen

Background

CD98 is a member of the solute carrier family and a cell surface, transmembrane protein with an alpha amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. CD98 associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

View specific protocols for CD98 Antibody (NBP2-36491): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-36491AF350
Alexa Fluor 405 NBP2-36491AF405
Alexa Fluor 488 NBP2-36491AF488
Alexa Fluor 532 NBP2-36491AF532
Alexa Fluor 594 NBP2-36491AF594
Alexa Fluor 647 NBP2-36491AF647
Alexa Fluor 700 NBP2-36491AF700
Alexa Fluor 750 NBP2-36491AF750
Allophycocyanin NBP2-36491APC
Allophycocyanin/Cy7 NBP2-36491APCCY7
Biotin NBP2-36491B
DyLight 350 NBP2-36491UV
DyLight 405 NBP2-36491V
DyLight 488 NBP2-36491G
DyLight 550 NBP2-36491R
DyLight 594 NBP2-36491DL594
DyLight 650 NBP2-36491C
DyLight 680 NBP2-36491FR
DyLight 755 NBP2-36491IR
FITC NBP2-36491F
HRP NBP2-36491H
Janelia Fluor 549 NBP2-36491JF549
Janelia Fluor 646 NBP2-36491JF646
PE NBP2-36491PE
PE/Atto594 NBP2-36491PEATT594
PE/Cy5.5 NBP2-36491PECY55
PE/Cy7 NBP2-36491PECY7
PerCP NBP2-36491PCP

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Blogs on CD98.

CD98 - cell surface glycoprotein that promotes cell adhesion, growth, and survival
CD98 is a heterodimeric glycoprotein that contains an 80 kDa heavy chain and a 40 kDa light chain. The CD98 heavy chain is also known as the 4F2 antigen heavy chain or FRP-1, and it is encoded by the SLC3A2 gene. The CD98 heavy chain is capable of...  Read full blog post.

xCT: Friend or Foe?
There are two opposing sides to the controversial cysteine/glutamate antiporter. On one hand, it can be viewed a guardian of the cell, protecting it from the damaging oxidative stress that can cause cell death and even cancer. But, conversely, it has...  Read full blog post.

Glutathione and xCT: Chemoresistance in Tumor Cells
Glutathione, called GSH in its reduced form and GSSG or L(-)-Glutathione in its oxidized form, is an endogenous antioxidant found in most cells in the body. Glutathione's functions include detoxifying xenobiotics from the body, assisting in membrane t...  Read full blog post.

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Bioinformatics

Gene Symbol SLC3A2
Entrez
Uniprot