Immunohistochemistry-Paraffin: CD11c Antibody (ITGAX/1242) [NBP2-44598] - Formalin-fixed, paraffin-embedded human Tonsil stained with CD11c Monoclonal Antibody (ITGAX/1242) at 1ug/ml. Antigen retrieval in 10mM Tris with ...read more
Protein Array: CD11c Antibody (ITGAX/1242) [NBP2-44598] - Analysis of Protein Array containing more than 19,000 full-length human proteins using CD11c Antibody (ITGAX/1242). Z- and S- Score: The Z-score represents the ...read more
Recombinant human CD11c protein fragment (aa 637-827) (exact sequence is proprietary) (Uniprot: P20702)
Dendritic Cell Marker
Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.
Protein A or G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined.
145 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publication using NBP2-44598 in the following applications:
200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP2-54431)
Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C. Antibody is stable for 24 months. Non-hazardous.
Alternate Names for CD11c Antibody (ITGAX/1242)
95 alpha chain
95, alpha subunit
CD11 antigen-like family member C
CD11Cleu M5, alpha subunit
Integrin alpha X
integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
integrin, alpha X (complement component 3 receptor 4 subunit)
Leukocyte adhesion glycoprotein p150
Leukocyte adhesion receptor p150
leukocyte surface antigen p150
myeloid membrane antigen, alpha subunit
p150 95 integrin alpha chain
CD11c encodes the integrin alpha X chain protein. CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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