CD11c Antibody (ITGAX/1242) [HRP]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clone
ITGAX/1242
Clonality
Monoclonal
Host
Mouse
Conjugate
HRP

Order Details

CD11c Antibody (ITGAX/1242) [HRP] Summary

Immunogen
Recombinant human ITGAX protein fragment (aa 637-827) (exact sequence is proprietary)
Localization
Cell surface
Marker
Dendritic Cell Marker
Specificity
Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
ITGAX
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A or G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for CD11c Antibody (ITGAX/1242) [HRP]

  • 95 alpha chain
  • 95
  • 95, alpha subunit
  • CD11 antigen-like family member C
  • CD11c antigen
  • CD11c
  • CD11Cleu M5, alpha subunit
  • Integrin alpha X
  • integrin alpha-X
  • integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
  • integrin, alpha X (complement component 3 receptor 4 subunit)
  • ITGAX
  • Leu M5
  • Leukocyte adhesion glycoprotein p150
  • Leukocyte adhesion receptor p150
  • leukocyte surface antigen p150
  • myeloid membrane antigen, alpha subunit
  • p150 95 integrin alpha chain
  • p150,95 alpha
  • SLEB6

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-54431AF350
Alexa Fluor 405 NBP2-54431AF405
Alexa Fluor 488 NBP2-54431AF488
Alexa Fluor 532 NBP2-54431AF532
Alexa Fluor 594 NBP2-54431AF594
Alexa Fluor 647 NBP2-54431AF647
Alexa Fluor 700 NBP2-54431AF700
Alexa Fluor 750 NBP2-54431AF750
Allophycocyanin NBP2-54431APC
Allophycocyanin/Cy7 NBP2-54431APCCY7
Biotin NBP2-54431B
DyLight 350 NBP2-54431UV
DyLight 405 NBP2-54431V
DyLight 488 NBP2-54431G
DyLight 550 NBP2-54431R
DyLight 594 NBP2-54431DL594
DyLight 650 NBP2-54431C
DyLight 680 NBP2-54431FR
DyLight 755 NBP2-54431IR
FITC NBP2-54431F
HRP NBP2-54431H
Janelia Fluor 549 NBP2-54431JF549
Janelia Fluor 646 NBP2-54431JF646
PE NBP2-54431PE
PE/Atto594 NBP2-54431PEATT594
PE/Cy5.5 NBP2-54431PECY55
PE/Cy7 NBP2-54431PECY7
PerCP NBP2-54431PCP

Additional CD11c Products

Array NBP2-54431H

Bioinformatics Tool for CD11c Antibody (NBP2-54431H)

Discover related pathways, diseases and genes to CD11c Antibody (NBP2-54431H). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for CD11c Antibody (NBP2-54431H)

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Research Areas for CD11c Antibody (NBP2-54431H)

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Blogs on CD11c.

Gut-brain axis: microbiota influence behavior and mental well-being
By Jennifer Sokolowski, MD, PhD.Gut-microbiome interactionsOn and in our bodies, microbes outnumber our cells by about ten-to-one. Studies have revealed that the microbiome influences neurogenesis, cognition, and...  Read full blog post.

CD11b: Marker for a New Type of B Cell that Participates in Cell-Mediated Immunity
Think B lymphocytes just produce antibodies? Think again! Although, of course, B cells are vital for the humoral immune response, many studies in recent years have begun to uncover antibody-independent actions of B cells: regulating T cells and thus a...  Read full blog post.

Adhesion Receptor Molecule CD11b/c is the Point of Entry for many Infectious Diseases
Pathogenic microorganisms utilize a variety of cell surface receptors to gain entry into host cells and to bypass the natural defense mechanisms. One of the most prominent receptors used in this fashion is the leukocyte adhesion receptor CD11b/c. This...  Read full blog post.

CD11b/CD18 and Neutrophil-Epithelial Interactions as Targets for Anti-Inflammatory Therapies
The beta-2 integrins, a family of four cell surface transmembrane glycoproteins expressed only on leukocytes, include CD11a/CD18, CD11b/CD18, CD11c/CD18, and CD11d/CD18. They consist of a common beta subunit (CD18) and homologous alpha subunits (CD11a...  Read full blog post.

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Bioinformatics

Gene Symbol ITGAX