CD11c Antibody (ITGAX/1242) [Janelia Fluor® 549] Summary
Recombinant fragment (191 Amino acid residues between aa 600-850) of human ITGAX protein
Dendritic Cell Marker
Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.
Protein A or G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Flow Cytometry
Optimal dilution of this antibody should be experimentally determined.
Packaging, Storage & Formulations
Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Protein A or G purified
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
Alternate Names for CD11c Antibody (ITGAX/1242) [Janelia Fluor® 549]
- 95 alpha chain
- 95, alpha subunit
- CD11 antigen-like family member C
- CD11c antigen
- CD11Cleu M5, alpha subunit
- Integrin alpha X
- integrin alpha-X
- integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
- integrin, alpha X (complement component 3 receptor 4 subunit)
- Leu M5
- Leukocyte adhesion glycoprotein p150
- Leukocyte adhesion receptor p150
- leukocyte surface antigen p150
- myeloid membrane antigen, alpha subunit
- p150 95 integrin alpha chain
- p150,95 alpha
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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