CCR8 Antibody

Images

 
Immunohistochemistry-Paraffin: CCR8 Antibody [NLS3847] - Analysis of anti-CCR8 antibody with human lymph node, non-Hodgkins lymphoma.
Immunohistochemistry-Paraffin: CCR8 Antibody [NLS3847] - Analysis of anti-CCR8 antibody with tonsil, germinal center at 22 ug/ ml.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

CCR8 Antibody Summary

Immunogen
Synthetic 19 amino acid peptide from C-terminus of human CCR8.
Specificity
Human CCR8. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CCR8
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 22 ug/ml
Publications
Read Publication using NLS3847.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (95%), Gibbon (89%), Monkey (89%), Marmoset (84%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CCR8 Antibody

  • CC chemokine receptor 8
  • C-C CKR-8
  • CC-chemokine receptor chemr1
  • CC-CKR-8
  • CCR8
  • CCR-8
  • CD198
  • CDw198 antigen
  • CDw198
  • chemokine (C-C motif) receptor 8
  • chemokine (C-C) receptor 8
  • chemokine (C-C) receptor-like 2
  • Chemokine receptor-like 1
  • ChemR1
  • CKRL1
  • CKR-L1
  • CKRL1MGC129966
  • CMKBR8MGC129973
  • CMKBRL2C-C chemokine receptor type 8
  • CY6
  • GPRCL1
  • GPRCY6
  • GPR-CY6
  • TER-1
  • TER1CC chemokine receptor CHEMR1

Background

CCR8, a Chemokine Receptor, binds the CC-chemokine I-309, which is secreted by umbilical vein endothelial cells. CCR8 also binds viral monocyte inflammatory protein-I (vMIP-I), which is induced by Kaposi sarcoma-related human herpesvirus-8. CCR8 induces endothelial chemotaxis and may function as an HIV-1 co-receptor on primary human cells, contributing to HIV-1-induced thymic pathogenesis (Lee et al., 2000). CCR8 expression has been reported in spleen and thymus, natural-killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes. Increased expression has been seen in allergen-challenged atopic asthma. No CCR8 expression was found in mesangial cells of the kidney cortex. ESTs have been isolated from human normal kidney, eye, and B cell/lung/testis libraries and from human brain, germ cell, and pancreas cancer libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CCR8 Antibody (NLS3847)(1)

We have publications tested in 1 application: IHC-P.


Filter By Application
IHC-P
(1)
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Product General Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CCR8
Entrez
Uniprot