Predicted cross-reactivity based on sequence identity: Gorilla (95%), Gibbon (89%), Monkey (89%), Marmoset (84%).
Alternate Names for CCR8 Antibody
CC chemokine receptor 8
CC-chemokine receptor chemr1
chemokine (C-C motif) receptor 8
chemokine (C-C) receptor 8
chemokine (C-C) receptor-like 2
Chemokine receptor-like 1
CMKBRL2C-C chemokine receptor type 8
TER1CC chemokine receptor CHEMR1
CCR8, a Chemokine Receptor, binds the CC-chemokine I-309, which is secreted by umbilical vein endothelial cells. CCR8 also binds viral monocyte inflammatory protein-I (vMIP-I), which is induced by Kaposi sarcoma-related human herpesvirus-8. CCR8 induces endothelial chemotaxis and may function as an HIV-1 co-receptor on primary human cells, contributing to HIV-1-induced thymic pathogenesis (Lee et al., 2000). CCR8 expression has been reported in spleen and thymus, natural-killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes. Increased expression has been seen in allergen-challenged atopic asthma. No CCR8 expression was found in mesangial cells of the kidney cortex. ESTs have been isolated from human normal kidney, eye, and B cell/lung/testis libraries and from human brain, germ cell, and pancreas cancer libraries.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.