CCR8 Antibody - BSA Free

Immunohistochemistry-Paraffin: CCR8 Antibody [NLS3845] - Analysis of anti-CCR8 antibody with human tonsil, germinal center and mantle zone.

• Reactivity: Hu, Pm
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

CCR8 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 18 amino acid peptide from N-terminal extracellular domain of human CCR8.
• Epitope: N-Terminus extracellular domain
• Specificity: Human CCR8. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Primate (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CCR8
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 28 ug/ml
• Application Notes: .

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (83%), Marmoset (83%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CCR8 Antibody - BSA Free

• CC chemokine receptor 8
• C-C CKR-8
• CC-chemokine receptor chemr1
• CC-CKR-8
• CCR8
• CCR-8
• CD198
• CDw198 antigen
• CDw198
• chemokine (C-C motif) receptor 8
• chemokine (C-C) receptor 8
• chemokine (C-C) receptor-like 2
• Chemokine receptor-like 1
• ChemR1
• CKRL1
• CKR-L1
• CKRL1MGC129966
• CMKBR8MGC129973
• CMKBRL2C-C chemokine receptor type 8
• CY6
• GPRCL1
• GPRCY6
• GPR-CY6
• TER-1
• TER1CC chemokine receptor CHEMR1

Background

CCR8, a Chemokine Receptor, binds the CC-chemokine I-309, which is secreted by umbilical vein endothelial cells. CCR8 also binds viral monocyte inflammatory protein-I (vMIP-I), which is induced by Kaposi sarcoma-related human herpesvirus-8. CCR8 induces endothelial chemotaxis and may function as an HIV-1 co-receptor on primary human cells, contributing to HIV-1-induced thymic pathogenesis (Lee et al., 2000). CCR8 expression has been reported in spleen and thymus, natural-killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes. Increased expression has been seen in allergen-challenged atopic asthma. No CCR8 expression was found in mesangial cells of the kidney cortex. ESTs have been isolated from human normal kidney, eye, and B cell/lung/testis libraries and from human brain, germ cell, and pancreas cancer libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CCR8
• Entrez:
  • 1237(Human)