CCR6 Antibody (53103.111)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
53103.111
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.5 mg/ml

CCR6 Antibody (53103.111) Summary

Immunogen
Human CCR6 transfected NSO mouse myeloma cells.
Localization
Integral membrane protein
Specificity
Human CCR6 reacts with CCR6 transfected cells and not with the parent cell line by flow cytometry. The shows no cross-reactivity with CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CXCR1, CXCR2, CXCR3, CXCR4 and STRL33 transfected cells.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
CCR6
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Application Notes
Flow Cytometry Use 5ug for 10<sup>5</sup> cells. (Determined using human CCR-6 on peripheral blood mononuclear cells (PBMC)).Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
Positive Control
CCR6 Lysate (NBL1-08893)

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for CCR6 Antibody (53103.111)

  • BN-1
  • CC-CKR-6
  • CCR6
  • CCR-6
  • CD196 antigen
  • CD196
  • chemokine (C-C motif) receptor 6
  • CKR-L3G-protein coupled receptor 29
  • CKRL3LARC receptor
  • CMKBR6STRL22
  • DRY6
  • GPR29
  • GPR29C-C CKR-6
  • GPR-CY4
  • GPRCY4DRY-6
  • lymphocyte, 22
  • STRL22

Background

CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein coupled receptors. It is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP 3 alpha). This receptor has been shown to be important for B lineage maturation and antigen driven B cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. CCR6 has been reported to be expressed in intestine, colon, liver, lymph node, spleen, lung, blood, umbilical cord, placenta, skin, and pancreas. It has also been reported to be expressed in lymphocytes, T cells, and B cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Applications: Flow

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CCR6
Entrez