CCL20/MIP-3 alpha Antibody (4N5F7) Summary
Full length recombinant mouse MIP-3 full length protein
Protein G purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
100 ug in 200 ul PBS containing 0.05% BSA.
0.05% Sodium Azide
Protein G purified
This monoclonal antibody is specific to mouse MIP-3 it will not cross-react with human MIP-3
Alternate Names for CCL20/MIP-3 alpha Antibody (4N5F7)
- beta chemokine exodus-1
- Beta-chemokine exodus-1
- CC chemokine LARC
- C-C motif chemokine 20
- chemokine (C-C motif) ligand 20
- LARCLiver and activation-regulated chemokine
- MIP3 alpha
- MIP-3 alpha
- MIP3AMacrophage inflammatory protein 3 alpha
- SCYA20Small-inducible cytokine A20
- small inducible cytokine subfamily A (Cys-Cys), member 20
MIP-3 is a small cytokine of the CC chemokine family. It acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. It is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues (Zhong W et al, 2010). It is expressed constitutively by keratinocytes in epidermal layers of the skin, intestinal mucosa, epithelial crypts of tonsils, and the epithelium of Payer's patches in the intestine. MIP-3 triggers an adaptive immune response primarily by attracting immature dendritic cells expressing CCR6 on their surfaces to the site of inflammation, and allows the dendritic cell to take up a foreign antigen and to mature. After binding, CCR6 expression is down-regulated, causing the dendritic cell to migrate to the lymph nodes, where it binds via CCR7 and presents the antigen to CD8 T cells. Thus it forms a bridge between innate and adaptive immune response (Hoover DM et al, 2002). MIP-3 plays immense role in various cancer entities, such as leukaemia, lymphoma, melanoma, hepatocellular carcinoma, prostate cancer, colorectal adenocarcinoma and lung and oral squamous cell carcinoma (He S et al, 2010). MIP-3 along with its corresponding receptor CCR6, is significantly up-regulated in patients with pancreatic cancer. But inhibition of CCR6 signaling or neutralization of MIP-3 or inhibition of its production and activity may be useful in preventing further progression of the disease and may be a future basic treatment strategy in the management of pancreatic cancer (Rubie C et al, 2010).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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