Mouse CXCL1/KC DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse CXCL1/KC DuoSet ELISA, 15 Plate Summary

• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Cxcl1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CXCL1/KC DuoSet ELISA, 15 Plate

• CINC1
• CINC-1
• CXCL1
• FSP
• GRO alpha
• GRO1
• GROa
• KC
• MGSA
• MGSA-a
• MGSA-alpha
• NAP-3
• SCYB1

Background

CXCL1/GRO alpha, also known as KC in mouse and CINC-1 in rat, is a member of the CXC family of chemokines. Human CXCL1/GRO alpha is 107 amino acids (aa) in length with a predicted molecular weight of 11 kDa. The mouse and rat orthologs share 57% and 59% amino acid sequence identity with the human protein, respectively. Genome-wide analysis suggests that the protein encoded by the mouse Cxcl3 gene is homologous to human CXCL1/GRO alpha protein. Human CXCL1/GRO alpha can be cleaved into three isoforms CXCL1/GRO alpha (aa 4-73), CXCL1/GRO alpha (aa 5-73), and CXCL1/GRO alpha (aa 6-73) which show higher activity than the full length protein. CXCL1/GRO alpha is secreted by mast cells and macrophages whereupon it acts as a chemoattractant for neutrophils.

Publications for CXCL1/GRO alpha/KC/CINC-1 (DY453)(229)

Publications using DY453

• HL Simpson, CL Roberts, LM Thompson, CR Leiper, N Gittens, E Trotter, CA Duckworth, S Papoutsopo, F Miyajima, P Roberts, N O'Kennedy, JM Rhodes, BJ Campbell Soluble Non-Starch Polysaccharides From Plantain (Musa x paradisiaca L.) Diminish Epithelial Impact of Clostridioides difficile Frontiers in Pharmacology, 2021;12(0):766293. 2021 [PMID: 34955836] (Mouse)
• KC Ngamsri, RA Putri, C Jans, K Schindler, A Fuhr, Y Zhang, J Gamper-Tsi, S Ehnert, FM Konrad CXCR4 and CXCR7 Inhibition Ameliorates the Formation of Platelet-Neutrophil Complexes and Neutrophil Extracellular Traps through Adora2b Signaling International Journal of Molecular Sciences, 2021;22(24):. 2021 [PMID: 34948374] (Mouse)
• BY Lee, EKJ Hogg, CR Below, A Kononov, A Blanco-Gom, F Heider, J Xu, C Hutton, X Zhang, T Scheidt, K Beattie, A Lamarca, M McNamara, JW Valle, C Jørgensen Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis Nature Communications, 2021;12(1):7336. 2021 [PMID: 34921158] (Mouse)
• BL Spencer, U Tak, JC Mendonça, PE Nagao, M Niederweis, KS Doran A type VII secretion system in Group B Streptococcus mediates cytotoxicity and virulence PloS Pathogens, 2021;17(12):e1010121. 2021 [PMID: 34871327] (Mouse)
• SR Bruno, A Kumar, ZF Mark, R Chandrasek, E Nakada, N Chamberlai, B Mihavics, J Walzer, J Cahoon, AE Dixon, B Cunniff, V Anathy DRP1-Mediated Mitochondrial Fission Regulates Lung Epithelial Response to Allergen International Journal of Molecular Sciences, 2021;22(20):. 2021 [PMID: 34681784] (Mouse)
• N Majumder, M Velayutham, D Bitounis, VK Kodali, MH Hasan Mazu, J Amedro, VV Khramtsov, A Erdely, T Nurkiewicz, P Demokritou, EE Kelley, S Hussain Oxidized carbon black nanoparticles induce endothelial damage through C-X-C chemokine receptor 3-mediated pathway Redox Biology, 2021;47(0):102161. 2021 [PMID: 34624601] (Mouse)
• E Zajta, K Csonka, A Tóth, L Tiszlavicz, T Németh, A Orosz, Á Novák, M Csikós, C Vágvölgyi, A Mócsai, A Gácser Signaling through Syk or CARD9 Mediates Species-Specific Anti-Candida Protection in Bone Marrow Chimeric Mice MBio, 2021;12(4):e0160821. 2021 [PMID: 34465030]
• N Rufo, D Korovesis, S Van Eygen, R Derua, AD Garg, F Finotello, M Vara-Perez, J Rožanc, M Dewaele, PA de Witte, LG Alexopoulo, S Janssens, L Sinkkonen, T Sauter, SHL Verhelst, P Agostinis Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1alpha kinase inhibitor KIRA6 through HSP60 targeting Cell Death and Differentiation, 2021;0(0):. 2021 [PMID: 34453119] (Human)
• N Majumder, WT Goldsmith, VK Kodali, M Velayutham, SA Friend, VV Khramtsov, TR Nurkiewicz, A Erdely, PC Zeidler-Er, V Castranova, JR Harkema, EE Kelley, S Hussain Oxidant-induced epithelial alarmin pathway mediates lung inflammation and functional decline following ultrafine carbon and ozone inhalation co-exposure Redox Biology, 2021;46(0):102092. 2021 [PMID: 34418598] (Mouse)
• Z Yang, G Xu, B Wang, Y Liu, L Zhang, T Jing, M Tang, X Xu, K Jiao, L Xiang, Y Fu, D Tang, X Zhang, W Jin, G Zhuang, X Zhao, Y Liu USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade Nature Communications, 2021;12(1):4852. 2021 [PMID: 34381028] (Mouse)
• NM Pinheiro, R Banzato, I Tibério, MAM Prado, VF Prado, AK Hamouda, CM Prado Acute Lung Injury in Cholinergic-Deficient Mice Supports Anti-Inflammatory Role of alpha7 Nicotinic Acetylcholine Receptor International Journal of Molecular Sciences, 2021;22(14):. 2021 [PMID: 34299169] (Mouse)
• DJ Levy, A Goundry, RSS Laires, TFR Costa, CM Novo, DJ Grab, JC Mottram, APCA Lima Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host PloS Neglected Tropical Diseases, 2021;15(6):e0009526. 2021 [PMID: 34153047] (Mouse)
• C Chevalier, O Leymarie, L Sedano, B Da Costa, CA Richard, P Maisonnass, M Réfregiers, F Jamme, R Le Goffic PB1-F2 amyloid-like fibers correlate with pro-inflammatory signaling and respiratory distress in influenza-infected mice The Journal of Biological Chemistry, 2021;0(0):100885. 2021 [PMID: 34146545] (Mouse)
• A Doni, R Parente, I Laface, E Magrini, C Cunha, FS Colombo, JF Lacerda, A Campos, SN Mapelli, F Petroni, R Porte, T Schorn, A Inforzato, T Mercier, K Lagrou, J Maertens, JD Lambris, B Bottazzi, C Garlanda, M Botto, A Carvalho, A Mantovani Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus Nature Communications, 2021;12(1):3739. 2021 [PMID: 34145258] (Mouse)
• A Ulu, A Burr, AJ Heires, J Pavlik, T Larsen, PA Perez, C Bravo, NV DiPatrizio, M Baack, DJ Romberger, TM Nordgren A high docosahexaenoic acid diet alters lung inflammation and recovery following repetitive exposure to aqueous organic dust extracts: Role of DHA in repetitive organic dust exposure The Journal of nutritional biochemistry, 2021;0(0):108797. 2021 [PMID: 34126202] (Mouse)
• MG Daskalaki, K Axarlis, T Aspevik, M Orfanakis, O Kolliniati, I Lapi, M Tzardi, E Dermitzaki, M Venihaki, K Kousoulaki, C Tsatsanis Fish Sidestream-Derived Protein Hydrolysates Suppress DSS-Induced Colitis by Modulating Intestinal Inflammation in Mice Marine Drugs, 2021;19(6):. 2021 [PMID: 34071180] (Mouse)
• MTP de Oliveir, DS Coutinho, SS Guterres, AR Pohlmann, PMRE Silva, MA Martins, A Bernardi Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice Pharmaceutics, 2021;13(5):. 2021 [PMID: 34068619] (Mouse)
• M Kouwenberg, WPC Pulskens, L Diepeveen, M Bakker-van, CA Dinarello, MG Netea, LB Hilbrands, J van der Vl Reduced CXCL1 production by endogenous IL-37 expressing dendritic cells does not affect T cell activation PLoS ONE, 2021;16(5):e0251809. 2021 [PMID: 34029331] (Mouse)
• G Cavalli, IW Tengesdal, M Gresnigt, T Nemkov, RJW Arts, J Domínguez-, R Molteni, D Stefanoni, E Cantoni, L Cassina, S Giugliano, K Schraa, TS Mills, EM Pietras, EZ Eisenmenss, L Dagna, A Boletta, A D'Alessand, LAB Joosten, MG Netea, CA Dinarello The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity Cell Reports, 2021;35(1):108955. 2021 [PMID: 33826894] (Mouse)
• R Nehmar, L Fauconnier, J Alves-Filh, D Togbe, A DeCauwer, S Bahram, M Le Bert, B Ryffel, P Georgel Aryl hydrocarbon receptor (Ahr)-dependent Il-22 expression by type 3 innate lymphoid cells control of acute joint inflammation Journal of Cellular and Molecular Medicine, 2021;0(0):. 2021 [PMID: 33734594] (Mouse)
• P Wohlrab, M Johann Dan, W Schaubmayr, A Tiboldi, K Krenn, K Markstalle, R Ullrich, K Ulrich Kle, V Tretter Oxygen conditions oscillating between hypoxia and hyperoxia induce different effects in the pulmonary endothelium compared to constant oxygen conditions Physiological Reports, 2021;9(3):e14590. 2021 [PMID: 33565273] (Mouse)
• S Estfanous, K Krause, MNK Anne, M Eltobgy, K Caution, A Abu Khweek, K Hamilton, A Badr, K Daily, C Carafice, D Baetzhold, X Zhang, T Li, H Wen, MA Gavrilin, H Haffez, S Soror, AO Amer Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo Scientific Reports, 2021;11(1):855. 2021 [PMID: 33441602] (Mouse)
• E Mai, CM Percopo, AR Limkar, AC Sek, M Ma, HF Rosenberg Respiratory Epithelial Cells Respond to Lactobacillus plantarum but Provide No Cross-Protection against Virus-Induced Inflammation Viruses, 2020;13(1):. 2020 [PMID: 33374950] (Mouse)
• B Relja, B Yang, K Bundkirche, B Xu, K Köhler, C Neunaber Different experimental multiple trauma models induce comparable inflammation and organ injury Sci Rep, 2020;10(1):20185. 2020 [PMID: 33214576] (Mouse)
• M Jeljeli, LGC Riccio, S Chouzenoux, F Moresi, L Toullec, L Doridot, C Nicco, M Bourdon, L Marcellin, P Santulli, MS Abrão, C Chapron, F Batteux Macrophage Immune Memory Controls Endometriosis in Mice and Humans Cell Rep, 2020;33(5):108325. 2020 [PMID: 33147452] (Mouse)
• DM de Graaf, RJA Maas, SP Smeekens, E Eisenmesse, JS Redzic, MM Helsen, NE Powers, S Li, V Kalabokis, MS Gresnigt, LAB Joosten, CA Dinarello, FL van de Vee Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease Cytokine, 2020;137(0):155334. 2020 [PMID: 33128926] (Mouse)
• J Sun, DL LaRock, EA Skowronski, JM Kimmey, J Olson, Z Jiang, AJ O'Donoghue, V Nizet, CN LaRock The Pseudomonas aeruginosa protease LasB directly activates IL-1&beta EBioMedicine, 2020;60(0):102984. 2020 [PMID: 32979835] (Mouse)
• D Bonhomme, I Santecchia, F Vernel-Pau, M Caroff, P Germon, G Murray, B Adler, IG Boneca, C Werts Leptospiral LPS escapes mouse TLR4 internalization and TRIF?associated antimicrobial responses through O antigen and associated lipoproteins PLoS Pathog., 2020;16(8):e1008639. 2020 [PMID: 32790743] (Mouse)
• E Gimier, M Chervy, A Agus, A Sivignon, E Billard, M Privat, S Viala, R Minet-Quin, A Buisson, E Vazeille, N Barnich, J Denizot Methyl-donor supplementation prevents intestinal colonization by Adherent-Invasive E. coli in a mouse model of Crohn's disease Sci Rep, 2020;10(1):12922. 2020 [PMID: 32737335] (Mouse)
• S Abouelasra, M De Bondt, N Berghmans, M Gouwy, VLS de Oliveir, SC Oliveira, FA Amaral, P Proost, J Van Damme, S Struyf, M De Buck Biological Characterization of Commercial Recombinantly Expressed Immunomodulating Proteins Contaminated with Bacterial Products in the Year 2020: The SAA3 Case Mediators Inflamm., 2020;2020(0):6087109. 2020 [PMID: 32694927] (Mouse)
• L Gifre-Reno, E Ugarte-Ber, E Martens, L Boon, O Cano-Garri, E Martínez-N, T Luque, R Roca-Pinil, Ò Conchillo-, N Ferrer-Mir, A Villaverde, G Opdenakker, E Garcia-Fru, A Arís Recombinant Protein-Based Nanoparticles: Elucidating their Inflammatory Effects In Vivo and their Potential as a New Therapeutic Format Pharmaceutics, 2020;12(5):. 2020 [PMID: 32414218] (Mouse)
• M Mohammad, Z Hu, A Ali, PK Kopparapu, M Na, A Jarneborn, MDN Stroparo, MT Nguyen, A Karlsson, F Götz, R Pullerits, T Jin The role of Staphylococcus aureus lipoproteins in hematogenous septic arthritis Sci Rep, 2020;10(1):7936. 2020 [PMID: 32404866] (Mouse)
• N Weinelt, C Karathanas, S Smith, J Medler, S Malkusch, S Fulda, H Wajant, M Heilemann, SJL van Wijk Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNF&alpha-induced NF-?B signaling J. Leukoc. Biol., 2020;0(0):. 2020 [PMID: 32401398] (Human)
• A Sünderhauf, R Pagel, A Künstner, AE Wagner, J Rupp, SM Ibrahim, S Derer, C Sina Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice Nutrients, 2020;12(4):. 2020 [PMID: 32316544] (Mouse)
• SH Kim, JH Hong, WK Yang, JH Geum, HR Kim, SY Choi, YM Kang, HJ An, YC Lee Herbal Combinational Medication of Glycyrrhiza glabra, Agastache rugosa Containing Glycyrrhizic Acid, Tilianin Inhibits Neutrophilic Lung Inflammation by Affecting CXCL2, Interleukin-17/STAT3 Signal Pathways in a Murine Model of COPD Nutrients, 2020;12(4):. 2020 [PMID: 32230838] (Mouse)
• T Zhang, KY Wu, N Ma, LL Wei, M Garstka, W Zhou, K Li The C5a/C5aR2 axis promotes renal inflammation and tissue damage JCI Insight, 2020;5(7):. 2020 [PMID: 32191644] (Mouse)
• YM Khaw, C Cunningham, A Tierney, M Sivaguru, M Inoue Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis J Neuroinflammation, 2020;17(1):49. 2020 [PMID: 32019585] (Mouse)
• F Kirsebom, C Michalaki, M Agueda-Oya, C Johansson Neutrophils do not impact viral load or the peak of disease severity during RSV infection Sci Rep, 2020;10(1):1110. 2020 [PMID: 31980667] (Mouse)
• HI Muendlein, J Sarhan, BC Liu, WM Connolly, SA Schworer, I Smirnova, AY Tang, V Ilyukha, J Pietruska, S Tahmasebi, N Sonenberg, A Degterev, A Poltorak Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation Cell Rep, 2020;30(3):699-713.e4. 2020 [PMID: 31968247] (Mouse)
• CL Hsu, KD Chhiba, R Krier-Burr, S Hosakoppal, S Berdnikovs, ML Miller, PJ Bryce Allergic inflammation is initiated by IL-33-dependent crosstalk between mast cells and basophils PLoS ONE, 2020;15(1):e0226701. 2020 [PMID: 31940364] (Mouse)
• HQ Tran, RE Ley, AT Gewirtz, B Chassaing Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases Nat Commun, 2019;10(1):5650. 2019 [PMID: 31827095] (Mouse)
• NE Powers, B Swartzwelt, C Marchetti, DM de Graaf, A Lerchner, M Schlapschy, R Datar, U Binder, CK Edwards, A Skerra, CA Dinarello PASylation of IL-1 Receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis J. Biol. Chem., 2019;0(0):. 2019 [PMID: 31819009] (Mouse)
• A Rahman, KM Henry, KD Herman, AAR Thompson, HM Isles, C Tulotta, D Sammut, JJ Rougeot, N Khoshaein, AE Reese, K Higgins, C Tabor, I Sabroe, WJ Zuercher, CO Savage, AH Meijer, MK Whyte, DH Dockrell, SA Renshaw, LR Prince Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation Elife, 2019;8(0):. 2019 [PMID: 31613219] (Mouse)
• CH Kowalski, JD Kerkaert, KW Liu, MC Bond, R Hartmann, CD Nadell, JE Stajich, RA Cramer Fungal biofilm morphology impacts hypoxia fitness and disease progression Nat Microbiol, 2019;0(0):. 2019 [PMID: 31548684] (Mouse)
• E Morello, T Pérez-Bere, C Boisseau, T Baranek, A Guillon, D Bréa, P Lanotte, X Carpena, N Pietrancos, V Hervé, R Ramphal, N Cenac, M Si-Tahar Pseudomonas aeruginosa Lipoxygenase LoxA Contributes to Lung Infection by Altering the Host Immune Lipid Signaling Front Microbiol, 2019;10(0):1826. 2019 [PMID: 31474948] (Mouse)
• DR Lacerda, KA Costa, ALM Silveira, DF Rodrigues, AN Silva, JL Sabino, V Pinho, GB Menezes, DD Soares, MM Teixeira, AVM Ferreira Role of adipose tissue inflammation in fat pad loss induced by fasting in lean and mildly obese mice J. Nutr. Biochem., 2019;72(0):108208. 2019 [PMID: 31473506] (Mouse)
• BE Hsu, S Tabariès, RM Johnson, S Andrzejews, J Senecal, C Lehuédé, MG Annis, EH Ma, S Völs, L Ramsay, R Froment, A Monast, IR Watson, Z Granot, RG Jones, J St-Pierre, PM Siegel Immature Low-Density Neutrophils Exhibit Metabolic Flexibility that Facilitates Breast Cancer Liver Metastasis Cell Rep, 2019;27(13):3902-3915.e6. 2019 [PMID: 31242422] (Mouse)
• M Mohammad, MT Nguyen, C Engdahl, M Na, A Jarneborn, Z Hu, A Karlsson, R Pullerits, A Ali, F Götz, T Jin The YIN and YANG of lipoproteins in developing and preventing infectious arthritis by Staphylococcus aureus PLoS Pathog., 2019;15(6):e1007877. 2019 [PMID: 31226163] (Mouse)
• BVS Valiate, RU Alvarez, L Karra, CM Queiroz-Jú, FA Amaral, F Levi-Schaf, MM Teixeira The immunoreceptor CD300a controls the intensity of inflammation and dysfunction in a model of Ag-induced arthritis in mice J. Leukoc. Biol., 2019;0(0):. 2019 [PMID: 31107994] (Mouse)
• I Santecchia, F Vernel-Pau, O Rasid, J Quintin, M Gomes-Sole, IG Boneca, C Werts Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection PLoS Pathog., 2019;15(5):e1007811. 2019 [PMID: 31107928] (Mouse)
• J Luo, X An, Y Yao, C Erb, A Ferguson, JK Kolls, S Fan, K Chen Epigenetic Regulation of IL-17-Induced Chemokines in Lung Epithelial Cells Mediators Inflamm., 2019;2019(0):9050965. 2019 [PMID: 31080358] (Mouse)
• N Schaunaman, A Sanchez, KG Dimasuay, N Pavelka, M Numata, R Alam, RJ Martin, HW Chu Interleukin 1 Receptor-Like 1 (IL1RL1) Promotes Airway Bacterial and Viral Infection and Inflammation Infect. Immun., 2019;87(7):. 2019 [PMID: 31061143] (Mouse)
• EM Nakada, NR Bhakta, BR Korwin-Mih, A Kumar, N Chamberlai, SR Bruno, DG Chapman, SM Hoffman, N Daphtary, M Aliyeva, CG Irvin, AE Dixon, PG Woodruff, S Amin, ME Poynter, DH Desai, V Anathy Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers JCI Insight, 2019;4(9):. 2019 [PMID: 31045581] (Mouse)
• JL Fachi, JS Felipe, LP Pral, BK da Silva, RO Corrêa, MCP de Andrade, DM da Fonseca, PJ Basso, NOS Câmara, ÉL de Sales E, F Dos Santos, SES Guima, AM Thomas, JC Setubal, YT Magalhães, FL Forti, T Candreva, HG Rodrigues, MB de Jesus, SR Consonni, ADS Farias, P Varga-Weis, MAR Vinolo Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism Cell Rep, 2019;27(3):750-761.e7. 2019 [PMID: 30995474] (Mouse)
• VS Tapia, MJD Daniels, P Palazón-Ri, M Dewhurst, NM Luheshi, J Rivers-Aut, J Green, E Redondo-Ca, P Kaldis, G Lopez-Cast, D Brough The three cytokines IL-1?, IL-18, and IL-1? share related but distinct secretory routes J. Biol. Chem., 2019;294(21):8325-8335. 2019 [PMID: 30940725] (Mouse)
• P Mamareli, F Kruse, C Friedrich, N Smit, T Strowig, T Sparwasser, M Lochner Epithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile Eur. J. Immunol., 2019;0(0):. 2019 [PMID: 30802297] (Mouse)
• AC Luissint, HC Williams, W Kim, S Flemming, V Azcutia, RS Hilgarth, MNO Leary, TL Denning, A Nusrat, CA Parkos Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice Mucosal Immunol, 2019;0(0):. 2019 [PMID: 30745566] (Mouse)
• P Saha, BS Yeoh, X Xiao, RM Golonka, V Singh, Y Wang, M Vijay-Kuma PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium Mucosal Immunol, 2019;0(0):. 2019 [PMID: 30710097] (Mouse)
• A de Araújo, FN da Fonseca, TM Rocha, LB de Freitas, EVO Araújo, DVT Wong, RCP Lima Júnio, LKAM Leal Eugenol as a Promising Molecule for the Treatment of Dermatitis: Antioxidant and Anti-inflammatory Activities and Its Nanoformulation Oxid Med Cell Longev, 2018;2018(0):8194849. 2018 [PMID: 30647816] (Mouse)
• D Emal, E Rampanelli, N Claessen, FJ Bemelman, JC Leemans, S Florquin, MC Dessing Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection Sci Rep, 2019;9(1):106. 2019 [PMID: 30643171] (Mouse)
• U Kulkarni, RL Zemans, CA Smith, SC Wood, JC Deng, DR Goldstein Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality Mucosal Immunol, 2019;12(2):545-554. 2019 [PMID: 30617300] (Mouse)
• P Wohlrab, L Soto-Gonza, T Benesch, MP Winter, IM Lang, K Markstalle, V Tretter, KU Klein Intermittent Hypoxia Activates Duration-Dependent Protective and Injurious Mechanisms in Mouse Lung Endothelial Cells Front Physiol, 2018;9(0):1754. 2018 [PMID: 30574096] (Mouse)
• CC Campa, RL Silva, JP Margaria, T Pirali, MS Mattos, LR Kraemer, DC Reis, G Grosa, F Copperi, EM Dalmarco, RCP Lima-Júnio, S Aprile, V Sala, F Dal Bello, DS Prado, JC Alves-Filh, C Medana, GD Cassali, GC Tron, MM Teixeira, E Ciraolo, RC Russo, E Hirsch Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis Nat Commun, 2018;9(1):5232. 2018 [PMID: 30542075]
• V Ciancarell, L Lembo-Fazi, I Paciello, AK Bruno, S Jaillon, S Berardi, M Barbagallo, S Meron-Suda, D Cohen, A Molinaro, G Rossi, C Garlanda, ML Bernardini Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection PLoS Pathog., 2018;14(12):e1007469. 2018 [PMID: 30532257] (Mouse)
• SJ Gurczynski, N Nathani, HI Warheit-Ni, EM Hult, A Podsiad, J Deng, RL Zemans, U Bhan, BB Moore CCR2 mediates increased susceptibility to post-H1N1 bacterial pneumonia by limiting dendritic cell induction of IL-17 Mucosal Immunol, 2018;0(0):. 2018 [PMID: 30498200] (Mouse)
• TM Nordgren, AJ Heires, J Zempleni, BJ Swanson, C Wichman, DJ Romberger Bovine milk-derived extracellular vesicles enhance inflammation and promote M1 polarization following agricultural dust exposure in mice J. Nutr. Biochem., 2018;64(0):110-120. 2018 [PMID: 30476878] (Mouse)
• F Sato-Kanek, X Wang, S Yao, T Hosoya, FS Lao, K Messer, M Pu, NM Shukla, HB Cottam, M Chan, DA Carson, M Corr, T Hayashi Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy Biomed Res Int, 2018;2018(0):8091283. 2018 [PMID: 30406141] (Mouse)
• T Imai, T Matsumura, S Mayer-Lamb, CA Wells, E Ishikawa, SK Butcher, TC Barnett, MJ Walker, A Imamura, H Ishida, T Ikebe, T Miyamoto, M Ato, S Ohga, B Lepenies, NM van Sorge, S Yamasaki Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):. 2018 [PMID: 30352847] (Mouse)
• X Xiao, P Saha, BS Yeoh, JA Hipp, V Singh, M Vijay-Kuma Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects J. Nutr. Biochem., 2018;62(0):28-34. 2018 [PMID: 30218980] (Mouse)
• C McWherter, YJ Choi, RL Serrano, SK Mahata, R Terkeltaub, R Liu-Bryan Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling Arthritis Res. Ther., 2018;20(1):204. 2018 [PMID: 30189890] (Mouse)
• S Cicko, TC Köhler, CK Ayata, T Müller, N Ehrat, A Meyer, M Hossfeld, A Zech, F Di Virgili, M Idzko Extracellular ATP is a danger signal activating P2X7 receptor in a LPS mediated inflammation (ARDS/ALI) Oncotarget, 2018;9(55):30635-30648. 2018 [PMID: 30093975] (Mouse)
• MF Serra, AC Cotias, CRR Pão, JB Daleprane, PB Jurgilas, GC Couto, EA Anjos-Valo, RSB Cordeiro, VF Carvalho, PMR Silva, MA Martins Repeated Allergen Exposure in A/J Mice Causes Steroid-Insensitive Asthma via a Defect in Glucocorticoid Receptor Bioavailability J. Immunol., 2018;0(0):. 2018 [PMID: 29914889] (Mouse)
• DT Skelly, ÉW Griffin, CL Murray, S Harney, C O'Boyle, E Hennessy, MA Dansereau, A Nazmi, L Tortorelli, JN Rawlins, DM Bannerman, C Cunningham Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms Mol. Psychiatry, 2019;24(10):1533-1548. 2019 [PMID: 29875474] (Mouse)
• C Portal, V Gouyer, R Léonard, MO Husson, F Gottrand, JL Desseyn Long-term dietary (n-3) polyunsaturated fatty acids show benefits to the lungs of Cftr F508del mice PLoS ONE, 2018;13(6):e0197808. 2018 [PMID: 29856782] (Mouse)
• IK Sundar, K Rashid, J Gerloff, J Rangel-Mor, D Li, I Rahman Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema FASEB J., 2018;0(0):fj201701518R. 2018 [PMID: 29630406] (Mouse)
• M Sakkou, P Chouvardas, L Ntari, A Prados, K Moreth, H Fuchs, V Gailus-Dur, M Hrabe de A, MC Denis, N Karagianni, G Kollias Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis JCI Insight, 2018;3(7):. 2018 [PMID: 29618659] (Mouse)
• DJ Sharkey, DJ Glynn, JE Schjenken, KP Tremellen, SA Robertson Interferon-gamma inhibits seminal plasma induction of colony stimulating factor 2 in mouse and human reproductive tract epithelial cells Biol. Reprod., 2018;0(0):. 2018 [PMID: 29596569] (Mouse)
• S Hoegl, N Burns, M Angulo, D Francis, CM Osborne, TW Mills, MR Blackburn, HK Eltzschig, CU Vohwinkel Capturing the multifactorial nature of ARDS - "Two-hit" approach to model murine acute lung injury Physiol Rep, 2018;6(6):e13648. 2018 [PMID: 29595879] (Mouse)
• A Sagiv, A Bar-Shai, N Levi, M Hatzav, L Zada, Y Ovadya, L Roitman, G Manella, O Regev, J Majewska, E Vadai, R Eilam, SW Feigelson, M Tsoory, M Tauc, R Alon, V Krizhanovs p53 in Bronchial Club Cells Facilitates Chronic Lung Inflammation by Promoting Senescence Cell Rep, 2018;22(13):3468-3479. 2018 [PMID: 29590616] (Mouse)
• J Fuchsloche, M Falk-Pauls, A Luzius, C Saggau, B Ruder, J Bolik, D Schmidt-Ar, A Linkermann, C Becker, P Rosenstiel, S Rose-John, D Adam The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis Oncotarget, 2018;9(16):12941-12958. 2018 [PMID: 29560122] (Mouse)
• V Besnard, R Dagher, T Madjer, A Joannes, M Jaillet, M Kolb, P Bonniaud, LA Murray, MA Sleeman, B Crestani Identification of periplakin as a major regulator of lung injury and repair in mice JCI Insight, 2018;3(5):. 2018 [PMID: 29515024] (Mouse)
• V Lamontain, T Schmid, D Weber-Stef, D Zeller, Z Jenei-Lanz, H Wajant, RH Straub, DN Männel Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice Cell. Mol. Immunol., 2018;0(0):. 2018 [PMID: 29375132] (Mouse)
• JB Herrmann, M Muensterma, L Strobel, A Schubert-U, TM Woodruff, SD Gray-Owen, A Klos, KO Johswich Complement C5a Receptor 1 Exacerbates the Pathophysiology of N.�meningitidis Sepsis and Is a Potential Target for Disease Treatment MBio, 2018;9(1):. 2018 [PMID: 29362231] (Mouse)
• L Boutens, GJ Hooiveld, S Dhingra, RA Cramer, MG Netea, R Stienstra Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses Diabetologia, 2018;0(0):. 2018 [PMID: 29333574] (Mouse)
• MS Gresnigt, M Jaeger, RK Subbarao M, O Rasid, G Jouvion, C Fitting, WJG Melchers, TD Kanneganti, A Carvalho, O Ibrahim-Gr, FL van de Vee The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression Front Immunol, 2017;8(0):1777. 2017 [PMID: 29326692] (Mouse)
• EE Hornick, B Banoth, AM Miller, ZR Zacharias, N Jain, ME Wilson, KN Gibson-Cor, KL Legge, GA Bishop, FS Sutterwala, SL Cassel Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection J. Immunol., 2017;0(0):. 2017 [PMID: 29282312] (Mouse)
• BJH Banaschews, B Baer, C Arsenault, T Jazey, EJA Veldhuizen, J Delport, T Gooyers, JF Lewis, HP Haagsman, RAW Veldhuizen, C Yamashita The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens Sci Rep, 2017;7(1):15545. 2017 [PMID: 29138462] (Mouse)
• Y Kim, AG Wu, A Jaja-Chime, BL Graf, C Waterman, MP Verzi, I Raskin Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice PLoS ONE, 2017;12(9):e0184709. 2017 [PMID: 28922365] (Mouse)
• L Kosack, R Gawish, A Lercher, B Vilagos, A Hladik, K Lakovits, A Bhattachar, C Schliehe, I Mesteri, S Knapp, A Bergthaler The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis Sci Rep, 2017;7(1):11289. 2017 [PMID: 28900132] (Mouse)
• K Watanabe, CA Gilchrist, MJ Uddin, SL Burgess, MM Abhyankar, SN Moonah, Z Noor, JR Donowitz, BN Schneider, T Arju, E Ahmed, M Kabir, M Alam, R Haque, P Pramoonjag, B Mehrad, WA Petri Microbiome-mediated neutrophil recruitment via CXCR2 and protection from amebic colitis PLoS Pathog., 2017;13(8):e1006513. 2017 [PMID: 28817707] (Mouse)
• AL Jung, CE Herkt, C Schulz, K Bolte, K Seidel, N Scheller, A Sittka-Sta, W Bertrams, B Schmeck Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles Sci Rep, 2017;7(1):6301. 2017 [PMID: 28740179] (Mouse)
• APL D'Almeida, MT Pacheco de, ÉT de Souza, D de Sá Cout, BT Ciambarell, CR Gomes, T Terroso, SS Guterres, AR Pohlmann, PM Silva, MA Martins, A Bernardi ?-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice Int J Nanomedicine, 2017;12(0):4479-4491. 2017 [PMID: 28684908] (Mouse)
• G Stokman, L Kors, PJ Bakker, E Rampanelli, N Claessen, GJD Teske, L Butter, H van Andel, MA van den Be, PWB Larsen, MC Dessing, CJ Zuurbier, SE Girardin, S Florquin, JC Leemans NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity J. Exp. Med., 2017;0(0):. 2017 [PMID: 28626071] (Mouse)
• JA Espinoza, MA León, PF Céspedes, RS Gómez, G Canedo-Mar, SA Riquelme, FJ Salazar-Ec, P Blancou, T Simon, I Anegon, MK Lay, PA González, CA Riedel, SM Bueno, AM Kalergis Heme Oxygenase-1 Modulates Human Respiratory Syncytial Virus Replication and Lung Pathogenesis during Infection J. Immunol., 2017;0(0):. 2017 [PMID: 28566367] (Mouse)
• JM Orellana, K Kampe, F Schulze, J Sieber, AW Jehle Fetuin-A aggravates lipotoxicity in podocytes via interleukin-1 signaling Physiol Rep, 2017;5(10):. 2017 [PMID: 28554965] (Mouse)
• DW Wojkowska, P Szpakowski, A Glabinski Interleukin 17A Promotes Lymphocytes Adhesion and Induces CCL2 and CXCL1 Release from Brain Endothelial Cells Int J Mol Sci, 2017;18(5):. 2017 [PMID: 28481289] (Mouse)
• E Jentho, M Bodden, C Schulz, AL Jung, K Seidel, B Schmeck, W Bertrams microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1 PLoS ONE, 2017;12(4):e0176204. 2017 [PMID: 28445535] (Mouse)
• MC Souza, DM Fonseca, A Kanashiro, L Benevides, TS Medina, MS Dias, WA Andrade, G Bonfá, MAB Silva, A Gozzi, MC Borges, RT Gazzinelli, JC Alves-Filh, FQ Cunha, JS Silva Chronic Toxoplasma gondii Infection Exacerbates Secondary Polymicrobial Sepsis Front Cell Infect Microbiol, 2017;7(0):116. 2017 [PMID: 28439500] (Mouse)
• CT Molloy, JS Andonian, HM Seltzer, MC Procario, ME Watson, JB Weinberg Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection Virology, 2017;507(0):64-74. 2017 [PMID: 28410483] (Mouse)
• KL Chan, TH Tam, P Boroumand, D Prescott, SR Costford, NK Escalante, N Fine, Y Tu, SJ Robertson, D Prabaharan, Z Liu, PJ Bilan, MW Salter, M Glogauer, SE Girardin, DJ Philpott, A Klip Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance Cell Rep, 2017;18(10):2415-2426. 2017 [PMID: 28273456] (Mouse)
• P Martin, G Palmer, E Rodriguez, CA Seemayer, J Palomo, D Talabot-Ay, C Gabay Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses J. Immunol, 2017;0(0):. 2017 [PMID: 28235865] (Mouse)
• T Hartwig, A Montinaro, S von Karste, A Sevko, S Surinova, A Chakravart, L Taraborrel, P Draber, E Lafont, F Arce Varga, MA El-Bahrawy, SA Quezada, H Walczak The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2 Mol. Cell, 2017;65(4):730-742.e5. 2017 [PMID: 28212753] (Mouse)
• CM Henry, SJ Martin Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory FADDosome Complex upon TRAIL Stimulation Mol. Cell, 2017;65(4):715-729.e5. 2017 [PMID: 28212752] (Mouse)
• D Jiang, R Berman, Q Wu, C Stevenson, HW Chu The Anti-inflammatory Effect of Alpha-1 Antitrypsin in Rhinovirus-infected Human Airway Epithelial Cells J Clin Cell Immunol, 2016;7(6):. 2016 [PMID: 28191362] (Mouse)
• R Th„nert, O Goldmann, A Beineke, E Medina Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection Nat Commun, 2017;8(0):14268. 2017 [PMID: 28155859] (Mouse)
• Ismé M de Kleer Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung Immunity, 2016;45(6):1285-1298. 2016 [PMID: 27939673] (Mouse)
• Jand Venes R Medeiros Carvacrol reduces irinotecan-induced intestinal mucositis through inhibition of inflammation and oxidative damage via TRPA1 receptor activation Chem. Biol. Interact., 2016;260(0):129-140. 2016 [PMID: 27838229] (Mouse)
• Nigel Mackman Protease-Activated Receptor 1 Enhances Poly I:C Induction of the Antiviral Response in Macrophages and Mice J Innate Immun, 2016;0(0):. 2016 [PMID: 27820939] (Mouse)
• DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma JCI Insight, 2016;1(18):e88811. 2016 [PMID: 27812543] (Mouse)
• The Influenza Virus Protein PB1-F2 Increases Viral Pathogenesis through Neutrophil Recruitment and NK Cells Inhibition PLoS ONE, 2016;11(10):e0165361. 2016 [PMID: 27798704] (Mouse)
• Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function Proc Natl Acad Sci USA, 2016;0(0):. 2016 [PMID: 27671649] (Mouse)
• Impact of Microbiota on Resistance to Ocular Pseudomonas aeruginosa-Induced Keratitis PLoS Pathog., 2016;12(9):e1005855. 2016 [PMID: 27658245] (Mouse)
• Klebsiella pneumoniae Siderophores Induce Inflammation, Bacterial Dissemination, and HIF-1? Stabilization during Pneumonia MBio, 2016;7(5):. 2016 [PMID: 27624128] (Mouse)
• NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury J Leukoc Biol, 2016;0(0):. 2016 [PMID: 27601626] (Mouse)
• Poly-N-acetyl glucosamine production by Staphylococcus epidermidis cells increases their in vivo pro-inflammatory effect Infect Immun, 2016;0(0):. 2016 [PMID: 27481237] (Mouse)
• Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI) PLoS ONE, 2016;11(7):e0159417. 2016 [PMID: 27437704] (Mouse)
• Carrie A Cowardin Glucosylation drives the innate inflammatory response to Clostridium difficile Toxin A Infect Immun, 2016;0(0):. 2016 [PMID: 27271747] (Mouse)
• Eun-Jeong Yoon Contribution of the Ade Resistance-Nodulation-Cell Division-Type Efflux Pumps to Fitness and Pathogenesis of Acinetobacter baumannii MBio, 2016;7(3):. 2016 [PMID: 27247231] (Mouse)
• Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor Sci Rep, 2016;6(0):26490. 2016 [PMID: 27215684] (Mouse)
• Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice PLoS ONE, 2016;11(5):e0155784. 2016 [PMID: 27195463] (Mouse)
• Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide Sci Rep, 2016;6(0):26071. 2016 [PMID: 27184415] (Mouse)
• C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF-?B Activation in Neutrophils J Immunol, 2016;196(5):2319-26. 2016 [PMID: 26800872] (Mouse)
• Carlucci F, Ishaque A, Ling G, Szajna M, Sandison A, Donatien P, Cook H, Botto M C1q Modulates the Response to TLR7 Stimulation by Pristane-Primed Macrophages: Implications for Pristane-Induced Lupus. J Immunol, 2015;196(4):1488-94. 2015 [PMID: 26773156] (Mouse)
• Marro B, Grist J, Lane T Inducible Expression of CXCL1 within the Central Nervous System Amplifies Viral-Induced Demyelination. J Immunol, 2016;196(4):1855-64. 2016 [PMID: 26773148] (Mouse)
• Brown A, Murphy A, Lalor S, Leech J, O'Keeffe K, Mac Aogain M, O'Halloran D, Lacey K, Tavakol M, Hearnden C, Fitzgerald-Hughes D, Humphreys H, Fennell J, van Wamel W, Foster T, Geoghegan J, Lavelle E, Rogers T, McLoughlin R Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection. PLoS Pathog, 2015;11(11):e1005226. 2015 [PMID: 26539822] (Mouse)
• Shah D, Romero F, Zhu Y, Duong M, Sun J, Walsh K, Summer R C1q Deficiency Promotes Pulmonary Vascular Inflammation and Enhances the Susceptibility of the Lung Endothelium to Injury. J Biol Chem, 2015;290(49):29642-51. 2015 [PMID: 26487714] (Mouse)
• Hamers A, van Dam L, Teixeira Duarte J, Vos M, Marinkovic G, van Tiel C, Meijer S, van Stalborch A, Huveneers S, Te Velde A, de Jonge W, de Vries C Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFkappaB Activity in Macrophages. PLoS ONE, 2015;10(8):e0133598. 2015 [PMID: 26241646] (Mouse)
• Hoegl S, Brodsky K, Blackburn M, Karmouty-Quintana H, Zwissler B, Eltzschig H Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury. J Immunol, 2015;195(4):1815-24. 2015 [PMID: 26188061] (Mouse)
• Hong E, Song J, Shim A, Lee B, Kwon B, Song H, Kim Y, Chang S, Jeong H, Kim J, Seo S, Kim H, Kwon Y, Ko H Coadministration of Hedera helix L. Extract Enabled Mice to Overcome Insufficient Protection against Influenza A/PR/8 Virus Infection under Suboptimal Treatment with Oseltamivir. PLoS ONE, 2015;10(6):e0131089. 2015 [PMID: 26098681] (Mouse)
• Lunding L, Webering S, Vock C, Behrends J, Wagner C, Holscher C, Fehrenbach H, Wegmann M Poly(inosinic-cytidylic) acid-triggered exacerbation of experimental asthma depends on IL-17A produced by NK cells. J Immunol, 2015;194(12):5615-25. 2015 [PMID: 25972482] (Mouse)
• Segueni N, Vigne S, Palmer G, Bourigault M, Olleros M, Vesin D, Garcia I, Ryffel B, Quesniaux V, Gabay C Limited Contribution of IL-36 versus IL-1 and TNF Pathways in Host Response to Mycobacterial Infection. PLoS ONE, 2015;10(5):e0126058. 2015 [PMID: 25950182] (Mouse)
• Alissafi T, Hatzioannou A, Ioannou M, Sparwasser T, Grun J, Grutzkau A, Verginis P De novo-induced self-antigen-specific Foxp3+ regulatory T cells impair the accumulation of inflammatory dendritic cells in draining lymph nodes. J Immunol, 2015;194(12):5812-24. 2015 [PMID: 25948818] (Mouse)
• Dau T, Sarker R, Yildirim A, Eickelberg O, Jenne D Autoprocessing of neutrophil elastase near its active site reduces the efficiency of natural and synthetic elastase inhibitors. Nat Commun, 2015;6(0):6722. 2015 [PMID: 25857284] (Mouse)
• Lunghi B, De Cunto G, Cavarra E, Fineschi S, Bartalesi B, Lungarella G, Lucattelli M Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema. PLoS ONE, 2015;10(3):e0119797. 2015 [PMID: 25790295] (Mouse)
• Chiba N, Shimada K, Chen S, Jones H, Alsabeh R, Slepenkin A, Peterson E, Crother T, Arditi M Mast cells play an important role in chlamydia pneumoniae lung infection by facilitating immune cell recruitment into the airway. J Immunol, 2015;194(8):3840-51. 2015 [PMID: 25754739] (Mouse)
• Herbst S, Shah A, Mazon Moya M, Marzola V, Jensen B, Reed A, Birrell M, Saijo S, Mostowy S, Shaunak S, Armstrong-James D Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus. EMBO Mol Med, 2015;7(3):240-58. 2015 [PMID: 25637383]
• Kearney C, Cullen S, Tynan G, Henry C, Clancy D, Lavelle E, Martin S Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production. Cell Death Differ, 2015;22(8):1313-27. 2015 [PMID: 25613374] (Mouse)
• Barra , Nicole G, Palanivel , Rengasam, Denou , Emmanuel, Chew , Marianne, Gillgrass , Amy, Walker , Tina D, Kong , Josh, Richards , Carl D, Jordana , Manel, Collins , Stephen, Trigatti , Bernardo, Holloway , Alison C, Raha , Sandeep, Steinberg , Gregory, Ashkar , Ali A Interleukin-15 modulates adipose tissue by altering mitochondrial mass and activity. PLoS ONE, 2014;9(12):e114799. 2014 [PMID: 25517731] (Mouse)
• Role of IL-1β in experimental cystic fibrosis upon P. aeruginosa infection. PLoS ONE, 2014;9(12):e114884. 2014 [PMID: 25500839] (Mouse)
• Zhao Y, Olonisakin T, Xiong Z, Hulver M, Sayeed S, Yu M, Gregory A, Kochman E, Chen B, Mallampalli R, Sun M, Silverstein R, Stolz D, Shapiro S, Ray A, Ray P, Lee J Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection. Mucosal Immunol, 2015;8(4):896-905. 2015 [PMID: 25492474] (Mouse)
• Schliehe C, Flynn E, Vilagos B, Richson U, Swaminathan S, Bosnjak B, Bauer L, Kandasamy R, Griesshammer I, Kosack L, Schmitz F, Litvak V, Sissons J, Lercher A, Bhattacharya A, Khamina K, Trivett A, Tessarollo L, Mesteri I, Hladik A, Merkler D, Kubicek S, Knapp S, Epstein M, Symer D, Aderem A, Bergthaler A The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nat Immunol, 2015;16(1):67-74. 2015 [PMID: 25419628] (Mouse)
• Slocum C, Coats S, Hua N, Kramer C, Papadopoulos G, Weinberg E, Gudino C, Hamilton J, Darveau R, Genco C Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammation. PLoS Pathog, 2014;10(7):e1004215. 2014 [PMID: 25010102] (Mouse)
• Grabiner M, Fu Z, Wu T, Barry K, Schwarzer C, Machen T Pseudomonas aeruginosa quorum-sensing molecule homoserine lactone modulates inflammatory signaling through PERK and eI-F2alpha. J Immunol, 2014;193(3):1459-67. 2014 [PMID: 24990083] (Mouse)
• Redlich S, Ribes S, Schutze S, Nau R Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections. J Neuroinflammation, 2014;11(0):108. 2014 [PMID: 24927796] (Mouse)
• Haste L, Hulland K, Bolton S, Yesilkaya H, McKechnie K, Andrew P Development and characterization of a long-term murine model of Streptococcus pneumoniae infection of the lower airways. Infect Immun, 2014;82(8):3289-98. 2014 [PMID: 24866797] (Mouse)
• De Filippo K, Neill D, Mathies M, Bangert M, McNeill E, Kadioglu A, Hogg N A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia. FASEB J, 2014;28(8):3600-8. 2014 [PMID: 24776746] (Mouse)
• Spann K, Loh Z, Lynch J, Ullah A, Zhang V, Baturcam E, Werder R, Khajornjiraphan N, Rudd P, Loo Y, Suhrbier A, Gale M, Upham J, Phipps S IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice. Am J Pathol, 2014;184(6):1795-806. 2014 [PMID: 24726644] (Mouse)
• Djukic M, Onken M, Schutze S, Redlich S, Gotz A, Hanisch U, Bertsch T, Ribes S, Hanenberg A, Schneider S, Bollheimer C, Sieber C, Nau R Vitamin d deficiency reduces the immune response, phagocytosis rate, and intracellular killing rate of microglial cells. Infect Immun, 2014;82(6):2585-94. 2014 [PMID: 24686054] (Mouse)
• Post , Sijranke, Heijink , Irene H, Petersen , Arjen H, de Bruin , Harold G, van Oosterhout , Antoon J, Nawijn , Martijn Protease-activated receptor-2 activation contributes to house dust mite-induced IgE responses in mice. PLoS ONE, 2014;9(3):e91206. 2014 [PMID: 24651123] (Mouse)
• Benmohamed F, Medina M, Wu Y, Maschalidi S, Jouvion G, Guillemot L, Chignard M, Manoury B, Touqui L Toll-like receptor 9 deficiency protects mice against Pseudomonas aeruginosa lung infection. PLoS ONE, 2014;9(3):e90466. 2014 [PMID: 24595157] (Mouse)
• Calil I, Zarpelon A, Guerrero A, Alves-Filho J, Ferreira S, Cunha F, Cunha T, Verri W Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw. PLoS ONE, 2014;9(3):e90013. 2014 [PMID: 24595131] (Mouse)
• Ballak D, van Essen P, van Diepen J, Jansen H, Hijmans A, Matsuguchi T, Sparrer H, Tack C, Netea M, Joosten L, Stienstra R MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice. PLoS ONE, 2014;9(2):e89615. 2014 [PMID: 24586913] (Mouse)
• Parker D, Planet P, Soong G, Narechania A, Prince A Induction of type I interferon signaling determines the relative pathogenicity of Staphylococcus aureus strains. PLoS Pathog, 2014;10(2):e1003951. 2014 [PMID: 24586160] (Mouse)
• Paradis M, Mindt B, Duerr C, Rojas O, Ng D, Boulianne B, McCarthy D, Yu M, Summers deLuca L, Ward L, Waldron J, Philpott D, Gommerman J, Fritz J A TNF-alpha-CCL20-CCR6 axis regulates Nod1-induced B cell responses. J Immunol, 2014;192(6):2787-99. 2014 [PMID: 24534531] (Mouse)
• Blanchet C, Jouvion G, Fitting C, Cavaillon J, Adib-Conquy M Protective or deleterious role of scavenger receptors SR-A and CD36 on host resistance to Staphylococcus aureus depends on the site of infection. PLoS ONE, 2014;9(1):e87927. 2014 [PMID: 24498223] (Mouse)
• Dreymueller D, Martin C, Schumacher J, Groth E, Boehm J, Reiss L, Uhlig S, Ludwig A Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes. J Immunol, 2014;192(2):722-31. 2014 [PMID: 24342803] (Mouse)
• Hansen , Michelle, Chen , Hui, Jones , Jessica, Langenbach , Shenna Y, Vlahos , Ross, Gualano , Rosa C, Morris , Margaret, Anderson , Gary P The lung inflammation and skeletal muscle wasting induced by subchronic cigarette smoke exposure are not altered by a high-fat diet in mice. PLoS ONE, 2013;8(11):e80471. 2013 [PMID: 24260397] (Mouse)
• Jiang D, Persinger R, Wu Q, Gross A, Chu H alpha1-Antitrypsin promotes SPLUNC1-mediated lung defense against Pseudomonas aeruginosa infection in mice. Respir Res, 2013;14(0):122. 2013 [PMID: 24209388] (Mouse)
• Moseman , Annie Pa, Moseman , E Ashley, Schworer , Stephen, Smirnova , Irina, Volkova , Tatyana, von Andrian , Ulrich, Poltorak , Alexande Mannose receptor 1 mediates cellular uptake and endosomal delivery of CpG-motif containing oligodeoxynucleotides. J Immunol, 2013;191(11):5615-24. 2013 [PMID: 24184555] (Mouse)
• Hamers A, Uleman S, van Tiel C, Kruijswijk D, van Stalborch A, Huveneers S, de Vries C, van 't Veer C Limited role of nuclear receptor Nur77 in Escherichia coli-induced peritonitis. Infect Immun, 2014;82(1):253-64. 2014 [PMID: 24166953] (Mouse)
• Hwang J, Sundar I, Yao H, Sellix M, Rahman I Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway. FASEB J, 2014;28(1):176-94. 2014 [PMID: 24025728] (Mouse)
• Gauvreau D, Gupta A, Fisette A, Tom F, Cianflone K Deficiency of C5L2 increases macrophage infiltration and alters adipose tissue function in mice. PLoS ONE, 2013;8(4):e60795. 2013 [PMID: 23630572] (Mouse)
• Zhou H, Yu M, Fukuda K, Im J, Yao P, Cui W, Bulek K, Zepp J, Wan Y, Kim T, Yin W, Ma V, Thomas J, Gu J, Wang J, DiCorleto P, Fox P, Qin J, Li X IRAK-M mediates Toll-like receptor/IL-1R-induced NFkappaB activation and cytokine production. EMBO J, 2013;32(4):583-96. 2013 [PMID: 23376919] (Mouse)
• Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. PLoS ONE, 2012;7(9):e44328. 2012 [PMID: 22957064] (Mouse)
• Wang , Penghua, Bai , Fengwei, Zenewicz , Lauren A, Dai , Jianfeng, Gate , David, Cheng , Gong, Yang , Long, Qian , Feng, Yuan , Xiaoling, Montgomery , Ruth R, Flavell , Richard, Town , Terrence, Fikrig , Erol IL-22 signaling contributes to West Nile encephalitis pathogenesis. PLoS ONE, 2012;7(8):e44153. 2012 [PMID: 22952908] (Mouse)
• Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Korner H, Cua D, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide D, Matsumoto K, Nakae S Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, Is crucial for murine asthma. J Immunol, 2012;189(7):3641-52. 2012 [PMID: 22942422] (Mouse)
• Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J. Exp. Med., 2012;209(8):1505-17. 2012 [PMID: 22802353] (Mouse)
• Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. J. Immunol., 2012;189(4):1911-9. 2012 [PMID: 22786765] (Mouse)
• Serezani CH, Kane S, Collins L Macrophage Dectin-1 Expression Is Controlled by Leukotriene B4 via a GM-CSF/PU.1 Axis. J. Immunol., 2012;189(2):906-15. 2012 [PMID: 22696442] (Mouse)
• Miegueu P, Cianflone K, Richard D, St-Pierre D Effect of secretin on preadipocyte, differentiating and mature adipocyte functions. Int J Obes (Lond), 2013;37(3):366-74. 2013 [PMID: 22565418] (Mouse)
• Habibzay , M, Saldana , J I, Goulding , J, Lloyd , C M, Hussell , T Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung. Mucosal Immunol, 2012;5(5):524-34. 2012 [PMID: 22549744] (Mouse)
• Chuquimia OD, Petursdottir DH, Rahman MJ, Hartl K, Singh M, Fernandez C The role of alveolar epithelial cells in initiating and shaping pulmonary immune responses: communication between innate and adaptive immune systems. PLoS ONE, 2012;7(2):e32125. 2012 [PMID: 22393384] (Mouse)
• Veliz Rodriguez T, Moalli F, Polentarutti N, Paroni M, Bonavita E, Anselmo A, Nebuloni M, Mantero S, Jaillon S, Bragonzi A, Mantovani A, Riva F, Garlanda C Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection. Infect. Immun., 2012;80(1):100-9. 2012 [PMID: 22025515] (Mouse)
• Steinwede K, Tempelhof O, Bolte K, Maus R, Bohling J, Ueberberg B, Langer F, Christman JW, Paton JC, Ask K, Maharaj S, Kolb M, Gauldie J, Welte T, Maus UA Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia. J. Immunol., 2011;187(10):5346-56. 2011 [PMID: 22003204] (Mouse)
• Le Goffic R, Leymarie O, Chevalier C, Rebours E, Da Costa B, Vidic J, Descamps D, Sallenave JM, Rauch M, Samson M, Delmas B Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein. PLoS Pathog., 2011;7(8):e1002202. 2011 [PMID: 21901097] (Mouse)
• McMillan DH, Baglole CJ, Thatcher TH, Maggirwar S, Sime PJ, Phipps RP Lung-targeted overexpression of the NF-kappaB member RelB inhibits cigarette smoke-induced inflammation. Am. J. Pathol., 2011;179(1):125-33. 2011 [PMID: 21703398] (Mouse)
• Arndt PG, Strahan B, Wang Y, Long C, Horiuchi K, Walcheck B Leukocyte ADAM17 Regulates Acute Pulmonary Inflammation. PLoS ONE, 2011;6(5):e19938. 2011 [PMID: 21603616] (Mouse)
• Breslow JM, Meissler JJ, Hartzell RR Innate immune responses to systemic Acinetobacter baumannii infection in mice: neutrophils, but not interleukin-17, mediate host resistance. Infect. Immun., 2011;79(8):3317-27. 2011 [PMID: 21576323] (Mouse)
• Hughes DJ, Kipar A, Leeming GH, Bennett E, Howarth D, Cummerson JA, Papoula-Pereira R, Flanagan BF, Sample JT, Stewart JP Chemokine binding protein M3 of murine gammaherpesvirus 68 modulates the host response to infection in a natural host. PLoS Pathog., 2011;7(3):e1001321. 2011 [PMID: 21445235] (Mouse)
• Moalli F, Paroni M, Veliz Rodriguez T, Riva F, Polentarutti N, Bottazzi B, Valentino S, Mantero S, Nebuloni M, Mantovani A, Bragonzi A, Garlanda C The Therapeutic Potential of the Humoral Pattern Recognition Molecule PTX3 in Chronic Lung Infection Caused by Pseudomonas aeruginosa. J. Immunol., 2011;186(9):5425-34. 2011 [PMID: 21441447] (Mouse)
• Bourgeois EA, Levescot A, Diem S, Chauvineau A, Berges H, Milpied P, Lehuen A, Damotte D, Gombert JM, Schneider E, Girard JP, Gourdy P, Herbelin A A natural protective function of invariant NKT cells in a mouse model of innate-cell-driven lung inflammation. Eur. J. Immunol., 2011;41(2):299-305. 2011 [PMID: 21268000] (Mouse)
• Russo RC, Garcia CC, Barcelos LS, Rachid MA, Guabiraba R, Roffe E, Souza AL, Sousa LP, Mirolo M, Doni A, Cassali GD, Pinho V, Locati M, Teixeira MM Phosphoinositide 3-kinase gamma plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice. J. Leukoc. Biol., 2011;89(2):269-82. 2011 [PMID: 21048214] (Mouse)
• Van Den Boogaard FE, Brands X, Schultz MJ, Levi M, Roelofs JJ, Van 't Veer C, van der Poll T Recombinant human tissue factor pathway inhibitor exerts anticoagulant, anti-inflammatory and antimicrobial effects in murine pneumococcal pneumonia. J. Thromb. Haemost., 2011;9(1):122-32. 2011 [PMID: 21029363]
• Sheldon IM, Roberts MH, Toll-like receptor 4 mediates the response of epithelial and stromal cells to lipopolysaccharide in the endometrium. PLoS ONE, 2010;5(9):e12906. 2010 [PMID: 20877575] (Mouse)
• Lamacchia C, Palmer G, Bischoff L, Rodriguez E, Talabot-Ayer D, Gabay C Distinct roles of hepatocyte- and myeloid cell-derived IL-1 receptor antagonist during endotoxemia and sterile inflammation in mice. J. Immunol., 2010;185(0):2516-24. 2010 [PMID: 20639493] (Mouse)
• van Neerven S, Regen T, Wolf D, Nemes A, Johann S, Beyer C, Hanisch UK, Mey J Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid. J. Neurochem., 2010;114(5):1511-26. 2010 [PMID: 20557428] (Mouse)
• von Vietinghoff S, Asagiri M, Azar D Defective regulation of CXCR2 facilitates neutrophil release from bone marrow causing spontaneous inflammation in severely NF-kappa B-deficient mice. J. Immunol., 2010;185(1):670-8. 2010 [PMID: 20519647] (Mouse)
• van Zoelen MA, Achouiti A, Schmidt AM, Yang H, Florquin S, Tracey KJ, van der Poll T Ligands of the receptor for advanced glycation end products, including high-mobility group box 1, limit bacterial dissemination during Escherichia coli peritonitis. Crit. Care Med., 2010;38(6):1414-22. 2010 [PMID: 20386310] (Mouse)
• Schutz M, Weiss EM, Schindler M, Hallstrom T, Zipfel PF, Linke D, Autenrieth IB Trimer stability of YadA is critical for virulence of Yersinia enterocolitica. Infect. Immun., 2010;78(6):2677-90. 2010 [PMID: 20308293] (Mouse)
• Sellge G, Magalhaes JG, Konradt C, Fritz JH, Salgado-Pabon W, Eberl G, Bandeira A, Di Santo JP, Sansonetti PJ, Phalipon A Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity. J. Immunol., 2010;184(4):2076-85. 2010 [PMID: 20089698] (Mouse)
• Couillin I, Vasseur V, Charron S, Gasse P, Tavernier M, Guillet J, Lagente V, Fick L, Jacobs M, Coelho FR, Moser R, Ryffel B IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema. J. Immunol., 2009;183(12):8195-202. 2009 [PMID: 20007584] (Mouse)
• Demoor T, Bracke KR, Vermaelen KY, Dupont L, Joos GF, Brusselle GG CCR7 modulates pulmonary and lymph node inflammatory responses in cigarette smoke-exposed mice. J. Immunol., 2009;183(12):8186-94. 2009 [PMID: 19923454] (Mouse)
• Zhu M, Hug C, Kasahara DI Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice. Am. J. Respir. Cell Mol. Biol., 2010;43(4):487-97. 2010 [PMID: 19915153] (Mouse)
• Zhou H, Andonegui G, Wong CH, Kubes P Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation. J. Immunol., 2009;183(8):5244-50. 2009 [PMID: 19786543] (Mouse)
• van der Veen BS, Petersen AH, Belperio JA, Satchell SC, Mathieson PW, Molema G, Heeringa P Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody-mediated glomerulonephritis. Clin. Exp. Immunol., 2009;158(1):143-53. 2009 [PMID: 19737241] (Mouse)
• Lagler H, Sharif O, Haslinger I, Matt U, Stich K, Furtner T, Doninger B, Schmid K, Gattringer R, de Vos AF, Knapp S TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia. J. Immunol., 2009;183(3):2027-36. 2009 [PMID: 19596984] (Mouse)
• Souza DG, Amaral FA, Fagundes CT, Coelho FM, Arantes RM, Sousa LP, Matzuk MM, Garlanda C, Mantovani A, Dias AA, Teixeira MM The long pentraxin PTX3 is crucial for tissue inflammation after intestinal ischemia and reperfusion in mice. Am. J. Pathol., 2009;174(4):1309-18. 2009 [PMID: 19286566] (Mouse)
• Wilkinson TS, Dhaliwal K, Hamilton TW, Lipka AF, Farrell L, Davidson DJ, Duffin R, Morris AC, Haslett C, Govan JR, Gregory CD, Sallenave JM, Simpson AJ Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment. Am. J. Pathol., 2009;174(4):1338-46. 2009 [PMID: 19264904] (Mouse)
• Lukkarinen H, Hogmalm A, Lappalainen U, Bry K Matrix metalloproteinase-9 deficiency worsens lung injury in a model of bronchopulmonary dysplasia. Am. J. Respir. Cell Mol. Biol., 2009;41(1):59-68. 2009 [PMID: 19097983] (Mouse)
• Leite-Junior JH, Garcia CS, Souza-Fernandes AB, Silva PL, Ornellas DS, Larangeira AP, Castro-Faria-Neto HC, Morales MM, Negri EM, Capelozzi VL, Zin WA, Pelosi P, Bozza PT, Rocco PR Methylprednisolone improves lung mechanics and reduces the inflammatory response in pulmonary but not in extrapulmonary mild acute lung injury in mice. Crit. Care Med., 2008;36(9):2621-8. 2008 [PMID: 18728474] (Mouse)
• Coelho FM, Pinho V, Amaral FA, Sachs D, Costa VV, Rodrigues DH, Vieira AT, Silva TA, Souza DG, Bertini R, Teixeira AL, Teixeira MM The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature. Arthritis Rheum., 2008;58(8):2329-37. 2008 [PMID: 18668539] (Mouse)
• Tarabishy AB, Aldabagh B, Sun Y, Imamura Y, Mukherjee PK, Lass JH, Ghannoum MA, Pearlman E MyD88 regulation of Fusarium keratitis is dependent on TLR4 and IL-1R1 but not TLR2. J. Immunol., 2008;181(1):593-600. 2008 [PMID: 18566426] (Mouse)
• Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM Adenosine receptors in regulation of dendritic cell differentiation and function. Blood, 2008;112(5):1822-31. 2008 [PMID: 18559975] (Mouse)
• Williams AS, Nath P, Leung SY, Khorasani N, McKenzie AN, Adcock IM, Chung KF Modulation of ozone-induced airway hyperresponsiveness and inflammation by interleukin-13. Eur. Respir. J., 2008;32(3):571-8. 2008 [PMID: 18417511] (Mouse)
• Cardona AE, Sasse ME, Liu L, Cardona SM, Mizutani M, Savarin C, Hu T, Ransohoff RM Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues. Blood, 2008;112(2):256-63. 2008 [PMID: 18347198] (Mouse)
• Nomellini V, Faunce DE, Gomez CR, Kovacs EJ An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition. J. Leukoc. Biol., 2008;83(6):1493-501. 2008 [PMID: 18319289]
• Doz E, Noulin N, Boichot E, Guenon I, Fick L, Le Bert M, Lagente V, Ryffel B, Schnyder B, Quesniaux VF, Couillin I Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent. J. Immunol., 2008;180(2):1169-78. 2008 [PMID: 18178857] (Mouse)
• Smith E, Zarbock A, Stark MA, Burcin TL, Bruce AC, Foley P, Ley K IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice. J. Immunol., 2007;179(12):8274-9. 2007 [PMID: 18056371] (Mouse)
• Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT Deletion of TLR5 results in spontaneous colitis in mice. J. Clin. Invest., 2007;117(12):3909-21. 2007 [PMID: 18008007] (Mouse)
• Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J. Clin. Invest., 2007;117(12):3786-99. 2007 [PMID: 17992263] (Mouse)
• Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, Jones SA, Rose-John S, Scheller J Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood, 2007;111(3):1021-8. 2007 [PMID: 17989316] (Mouse)
• Tsuruta Y, Park YJ, Siegal GP, Liu G, Abraham E Involvement of vitronectin in lipopolysaccaride-induced acute lung injury. J. Immunol., 2007;179(10):7079-86. 2007 [PMID: 17982099] (Mouse)
• Elizur A, Adair-Kirk TL, Kelley DG, Griffin GL, deMello DE, Senior RM Clara cells impact the pulmonary innate immune response to LPS. Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(2):L383-92. 2007 [PMID: 17526599] (Mouse)
• Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity, 2007;26(4):445-59. 2007 [PMID: 17433730] (Mouse)
• Fuse ET, Tateda K, Kikuchi Y, Matsumoto T, Gondaira F, Azuma A, Kudoh S, Standiford TJ, Yamaguchi K Role of Toll-like receptor 2 in recognition of Legionella pneumophila in a murine pneumonia model. J. Med. Microbiol., 2007;56(0):305-12. 2007 [PMID: 17314358] (Mouse)
• Witowski J, Ksiazek K, Warnecke C, Kuzlan M, Korybalska K, Tayama H, Wisniewska-Elnur J, Pawlaczyk K, Trominska J, Breborowicz A, Jorres A Role of mesothelial cell-derived granulocyte colony-stimulating factor in interleukin-17-induced neutrophil accumulation in the peritoneum. Kidney Int., 2007;71(6):514-25. 2007 [PMID: 17228364] (Mouse)
• Schnyder-Candrian S, Togbe D, Couillin I, Mercier I, Brombacher F, Quesniaux V, Fossiez F, Ryffel B, Schnyder B Interleukin-17 is a negative regulator of established allergic asthma. J. Exp. Med., 2006;203(12):2715-25. 2006 [PMID: 17101734] (Mouse)
• Vijay-Kumar M, Wu H, Jones R, Grant G, Babbin B, King TP, Kelly D, Gewirtz AT, Neish AS Flagellin suppresses epithelial apoptosis and limits disease during enteric infection. Am. J. Pathol., 2006;169(5):1686-700. 2006 [PMID: 17071592] (Mouse)
• Scott P, Ma H, Viriyakosol S, Terkeltaub R, Liu-Bryan R Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals. J. Immunol., 2006;177(9):6370-8. 2006 [PMID: 17056568] (Mouse)
• Rodriguez N, Wantia N, Fend F, Durr S, Wagner H, Miethke T Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniae. Eur. J. Immunol., 2006;36(5):1145-55. 2006 [PMID: 16609927] (Mouse)
• Alves-Filho JC, de Freitas A, Russo M, Cunha FQ Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis. Crit. Care Med., 2006;34(2):461-70. 2006 [PMID: 16424729] (Mouse)
• Lu FL, Johnston RA, Flynt L, Theman TA, Terry RD, Schwartzman IN, Lee A, Shore SA Increased pulmonary responses to acute ozone exposure in obese db/db mice. Am. J. Physiol. Lung Cell Mol. Physiol., 2006;290(5):L856-65. 2006 [PMID: 16373670] (Mouse)
• Noulin N, Quesniaux VF, Schnyder-Candrian S, Schnyder B, Maillet I, Robert T, Vargaftig BB, Ryffel B, Couillin I Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxin. J. Immunol., 2005;175(10):6861-9. 2005 [PMID: 16272344] (Mouse)
• Hajjar AM, Harowicz H, Liggitt HD, Fink PJ, Wilson CB, Skerrett SJ An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia. Am. J. Respir. Cell Mol. Biol., 2005;33(5):470-5. 2005 [PMID: 16100080] (Mouse)
• Kim KH, Burkhart K, Chen P, Frevert CW, Randolph-Habecker J, Hackman RC, Soloway PD, Madtes DK Tissue inhibitor of metalloproteinase-1 deficiency amplifies acute lung injury in bleomycin-exposed mice. Am. J. Respir. Cell Mol. Biol., 2005;33(3):271-9. 2005 [PMID: 15947421] (Mouse)
• Amendoeira FC, Frutuoso VS, Zanon C, Chedier LM, Figueiredo MR, Kaplan MA, Bandeira-Melo C, Bozza PT, Castro-Faria-Neto HC Anti-inflammatory activity in the aqueous crude extract of the leaves of Nidularium procerum: A bromeliaceae from the Brazilian coastal rain forest. Biol. Pharm. Bull., 2005;28(6):1010-5. 2005 [PMID: 15930736] (Mouse)
• Barcelos LS, Talvani A, Teixeira AS, Vieira LQ, Cassali GD, Andrade SP, Teixeira MM Impaired inflammatory angiogenesis, but not leukocyte influx, in mice lacking TNFR1. J. Leukoc. Biol., 2005;78(2):352-8. 2005 [PMID: 15894588] (Mouse)
• Allen L, Dockrell DH, Pattery T, Lee DG, Cornelis P, Hellewell PG, Whyte MK Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo. J. Immunol., 2005;174(6):3643-9. 2005 [PMID: 15749902] (Mouse)
• Yarovinsky TO, Powers LS, Butler NS, Bradford MA, Monick MM, Hunninghake GW Adenoviral infection decreases mortality from lipopolysaccharide-induced liver failure via induction of TNF-alpha tolerance. J. Immunol., 2003;171(5):2453-60. 2003 [PMID: 12928393] (Mouse)

Bioinformatics

• Gene Symbol: Cxcl1