Caspase-1 Antibody


Western Blot: Caspase-1 Antibody [NB100-56564] - Analysis of Caspase-1 using a polyclonal antibody. Human HeLa lysate probed with Caspase-1 antibody at 0.5 ug/ml.
Immunohistochemistry-Paraffin: Caspase-1 Antibody [NB100-56564] - Formalin-fixed, paraffin-embedded section of human reactive lymph node stained for Caspase-1 expression (NB100-56564) using a DAB chromogen and more

Product Details

Reactivity Hu, Mu, RatSpecies Glossary
Applications WB, IHC, IHC-P
1.0 mg/ml

Order Details

Caspase-1 Antibody Summary

A synthetic peptide corresponding to amino acids 371-390 RKVRFSFEQPDGRAQMPTTE of human Caspase-1.
The antibody recognizes full-length Caspase-1. The antibody also recognizes cleaved Caspase-1 forms that include amino acids 31-45.
Predicted Species
Rat (91%). Backed by our 100% Guarantee.
Protein G purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.05% Sodium Azide
1.0 mg/ml
Protein G purified


  • Western Blot 0.5-2 ug/ml
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
Read Publication using
NB100-56564 in the following applications:

  • WB
    1 publication

Reactivity Notes

Based on immunogen's sequence homology, this antibody is predicted to crossreact with Primates (100%), Rat (90%), Porcine (85%), Rabbit (85%) and Canine (70%).

Alternate Names for Caspase-1 Antibody

  • CASP1
  • CASP-1
  • caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta
  • caspase 1, apoptosis-related cysteine protease (interleukin 1, beta
  • Caspase1
  • caspase-1
  • EC 3.4.22
  • EC
  • ICE
  • ICEP45
  • IL-1 beta-converting enzyme
  • IL1BC CASP1 nirs variant 1
  • IL-1BC
  • IL1BCE
  • IL1B-convertase
  • interleukin 1-B converting enzyme
  • interleukin 1-beta convertase
  • Interleukin-1 beta convertase
  • Interleukin-1 beta-converting enzyme
  • p45


Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis (1). The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a tetramer to form the active enzyme. Caspase-1/ICE (IL-1b converting enzyme) is similar to the cell death gene CED-3 of Caenorhabditilis elegans and regulates multiple proinflammatory cytokines, including interleukin-1b and interferon-gamma-inducing factor.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Caspase-1 Antibody (NB100-56564)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Caspase-1 Antibody (NB100-56564). (Showing 1 - 1 of 1 FAQ).

  1. We are interested in your item, NB100-56564 (IMG-5025) and would like to confirm if it only recognizes subunit p10 and do not cross react to p20?
    • Our Caspase 1 antibody with catalogue number NB100-56564 (IMG-5025) was raised against a synthetic peptide corresponding to amino acids 371-390 of the human protein. According to the Uniprot listing these amino acids lie within the p10 subunit. The antibody recognises full-length Caspase-1, as well as cleaved Caspase-1 forms that include amino acids 31-45. Amino acids 31-45 lie within the propeptide. Unfortunately we have no testing data where we have used this antibody to probe the isolated p20 subunit. Based on the immunogen sequence it seems unlikely that the antibody would recognise p20, but I unfortunately do not have 100% certainty on this at the present time.

Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

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Blogs on Caspase-1.

NLRP3/NALP3 - Sensing and responding to pathogen infection
The inflammasome is a multi protein complex that is an important component of the innate immune response. The inflammasome is able to sense and respond to pathogen infections by recognizing pathogen-associated molecular patterns and mediating the ...  Read full blog post.

Caspase 10 - an initiator caspase in the extrinsic death receptor pathway
Apoptosis, also called programmed cell death, is an essential process in development and disease. The signaling networks that carry out apoptosis is consists of a series of endoproteases called caspases which are synthesized as inactive zymogens....  Read full blog post.

Caspase 7 - A key effector of the apoptotic pathway
Caspase-7 is an effector caspase with important roles in mediating cell death signaling. As an effector caspase, caspase-7 is cleaved and activated by initiator caspases such as caspase-1 (1). Like other caspase family proteins, caspase-7 contains a...  Read full blog post.

Caspase 1 - activating innate immune responses following infection or injury
Caspase-1 is an enzyme involved in the conversion of interleukin-1 into its active secreted form. Interleukin-1 mediates inflammatory responses during infection and disease. Caspase-1 is recruited to and activated by the inflammasome complex (1). Un...  Read full blog post.

Caspase-4 - a human protease with roles in inflammation and immunity
Caspases are a family of cysteine-aspartic acid proteases that cleave caspase proenzymes as well as other protein substrates. Caspases are well known for their role in apoptosis, but they also play a significant role in other cellular processes inc...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol CASP1

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