BIK Antibody [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 350

BIK Antibody [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human BIK
  Met1-Gln135
  Accession # Q13323
• Specificity: Detects human BIK in Western Blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BIK Antibody [Alexa Fluor® 350]

• Apoptosis inducer NBK
• BCL2-interacting killer (apoptosis-inducing)
• bcl-2-interacting killer
• BIK
• BIP1
• BP4
• NBK
• NBKapoptosis-inducing NBK

Background

Bcl-2-interacting killer (BIK; also known as NBK, BP4 and BIP-1) is a 19 kDa member of the BH3-only subfamily, Bcl-2 family of proteins. It is widely expressed, and serves as an initiator of cell death. It apparently participates in apoptosis by sequestering antiapoptotic cytoplasmic proteins of the Bcl-2 family and in autophagy by regulating cytosolic calcium levels. Human BIK-1 is 160 amino acids (aa) in length. It contains one BH3 domain (aa 57‑74), a “death segment” (aa 121‑134) and a transmembrane domain (aa 136‑156). BIK is likely to embed in both outer mitochondrial and ER membranes. Over amino acids 1‑135, human BIK shares only 45% aa identity with mouse BIK.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.