BIK Products

Antibodies
BIK Antibody
BIK Antibody
NB100-56109
Species: Hu, Mu, Rt, Ge
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
BIK Antibody [Unconjugated]
BIK Antibody [Unconjugated]
AF5474
Species: Hu
Applications: WB, IHC
Host: Sheep Polyclonal
BIK Antibody
BIK Antibody
NBP1-76704
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF
Host: Rabbit Polyclonal
Proteins
Recombinant Human BIK Protein ...
Recombinant Human BIK Protein
H00000638-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human BIK Protein ...
Recombinant Human BIK Protein
H00000638-Q01
Species: Hu
Applications: WB, ELISA, PA
BIK Recombinant Protein Antig ...
BIK Recombinant Protein Antigen
NBP2-33612PEP
Species: Hu
Applications: AC
RNAi
BIK RNAi
BIK RNAi
H00000638-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The Bcl-2 family of apoptosis-related genes plays central roles in regulating apoptotic pathways (reviewed in Thomadaki and Scorilas, 2006). Regulation of cell death through apoptosis is critical for the maintenance of homeostasis, defense against infectious agents, and normal development. Bcl-2 family proteins regulate apoptosis primarily through the regulation of mitochondrial outer membrane permeability. In mammals, the family consists of both prosurvival (antiapoptotic) and proapoptotic (prodeath) members. Cellular homeostasis is thought to be dependent on a balance between the actions of prosurvival and proapoptotic proteins. Bcl-2 family proteins can be divided into 3 main subfamilies on the basis of their function and the content of their Bcl-2 homology (BH) domains, for example: 1) Prosurvival: Bcl-2, Bcl-XL, Bcl-W, A1, and Mcl-1 2) Proapoptotic (multidomain): Bax, Bak, and Bok. 3) BH3-only (proapoptotic): Bad, Bcl-XS, Bid, Bik, Bim, Blk, Bmf, Bnip, Noxa, and Puma. Prosurvival members inhibit cells from undergoing apoptosis, whereas proapoptotic and BH3-only subfamily members promote apoptosis. There are 4 BH domains (1-4) conserved among Bcl-2 family proteins. The BH domains are important for function as well as for heterodimerization between family members. Typical prosurvival family members have all four BH domains (1-4), whereas proapoptotic (multidomain) members have BH1, 2 and 3 domains and BH3-only members have only the BH3 domain. Overall, the relative ratio of prosurvival and proapoptotic proteins determines the suseptibility of a cell to various apoptotic stimuli. Many Bcl-2 family proteins are differentially expressed in various malignancies and some are useful prognostic biomarkers. Prosurvival proteins are often elevated in diverse cancers and have the potential to confer resistance to both endogenous cell death stimuli and cancer treatments. Alterations in the ratio or levels of Bcl-2 family proteins have been also associated with nonmalignant diseases including neurodegenerative diseases, autoimmune diseases, AIDs, Down's syndrome, cardiovascular diseases, diabetes, glomerulonephritis, and muscular dystrophy. IMG-5696 recognizes Bik. Human Bik is a 160 amino acid protein, GenBank no. NP_001188.1.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 638
Alternate Names
  • BIP1
  • bcl-2-interacting killer
  • Apoptosis inducer NBK
  • NBKapoptosis-inducing NBK
  • BP4
  • BCL2-interacting killer (apoptosis-inducing)

Research Areas for BIK

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Phospho-Specific

Bioinformatics Tool for BIK

Discover related pathways, diseases and genes to BIK. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.