Bcl-2 Antibody (E17)



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Bcl-2 Antibody (E17) Summary

A synthetic peptide corresponding to residues between BH3 and BH4 of human Bcl-2 was used as immunogen.
Endoplasmic reticulum, outer mitochondrial membrane and intracellular membrane of the nuclear envelope.
The antibody does not cross-react with other Bcl-2 family members
Protein A or G purified
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Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
Tris Buffer, pH 7.3-7.7, with 1% BSA
0.01% Sodium Azide
0.01 mg/ml
Protein A or G purified


Application Notes
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
26 kDa

Reactivity Notes

Species cross reactivity tested by Western Blot only.


This is a high affinity, high titer antibody. Optimal dilutions should be determined by the end user. (Provided dilutions serve only as a suggestive starting point.)


The Bcl-2 family of proteins regulate apoptosis by controlling mitochondrial permeability and release of cytochrome c. Bcl-2 is an anti-apoptotic protein that resides in the outer mitochondrial wall and inhibits release of cytochrome c (1). Over-expression of Bcl-2 has been shown to promote cell survival by suppressing apoptosis. It has been documented that bcl-2 becomes deregulated in tumor cells as a result of translocation into the immunoglobulin heavy-chain locus and is therefore activated in B cell malignancies (2). It has also been shown that post-translational modification of Bcl-2, phosphorylation at serine 70, may be required to render its full and/or enhanced anti-apoptotic effect (3, 4).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Bcl-2 Antibody (NB110-55551) (0)

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BNIP3 - a regulator of mitochondrial autophagy and cell death
Bcl-2 nineteen-kilodalton interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein. BNIP3 localizes to the mitochondrial membrane where it plays a key role in mitochondrial autophagy and cell death pathways. Similar to other Bcl-2 family m...  Read full blog post.

BAG3 - Hsp70 is my friend!
The BAG proteins are a large family of chaperone regulators governing a wide range of cell processes such as proliferation, survival, stress response, tumorigenesis, neuronal differentiation, growth arrest and apoptosis as reviewed in Takayama et al1....  Read full blog post.

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Product PDFs


Gene Symbol BCL2

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