Bcl-2 Products

Antibodies
Bcl-2 Antibody
Bcl-2 Antibody
Species: Hu, Mu, Rt, Ca, Po, Bv, Fe
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
Bcl-2 Antibody (625509) [Unco ...
Bcl-2 Antibody (625509) [Unconjuga...
MAB8272
Species: Hu, Mu, Rt
Applications: WB, IHC, KO
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
Bcl-2 Antibody
Bcl-2 Antibody
NB100-56101
Species: Hu, Mu, Rt, Ca, Ma
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
Antibody Pairs
Bcl-2 Antibody Pair [HRP]
Bcl-2 Antibody Pair [HRP]
NBP2-79489
Species: Hu
Applications: ELISA
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
ELISA Kits
Human Total Bcl-2 DuoSet IC E ...
Human Total Bcl-2 DuoSet IC ELISA,...
DYC827B-2
Species: Hu
Applications: ELISA
Conjugate Catalog # Availability Size Price
Mouse Bcl-2 ELISA Kit (Colori ...
Mouse Bcl-2 ELISA Kit (Colorimetric)
NBP2-69946
Species: Mu
Applications: ELISA
Rat Bcl-2 ELISA Kit (Colorime ...
Rat Bcl-2 ELISA Kit (Colorimetric)
NBP2-69947
Species: Rt
Applications: ELISA
Proteins
Recombinant Human Bcl-2 (minu ...
Recombinant Human Bcl-2 (minus C-T...
827-BC
Species: Hu
Applications: Inhibition Activity
Formulation Catalog # Availability Price  
Recombinant Human Bcl-2 Prote ...
Recombinant Human Bcl-2 Protein
NBP2-34889
Species: Hu
Applications: PAGE
Bcl-2 Antibody Blocking Pepti ...
Bcl-2 Antibody Blocking Peptide
NB100-56098PEP
Species: Hu
Applications: AC

Description

The Bcl-2 family of proteins regulate apoptosis by controlling mitochondrial permeability and release of cytochrome c. Bcl-2 is an anti-apoptotic protein that resides in the outer mitochondrial wall and inhibits release of cytochrome c (1). Over-expression of Bcl-2 has been shown to promote cell survival by suppressing apoptosis. It has been documented that bcl-2 becomes deregulated in tumor cells as a result of translocation into the immunoglobulin heavy-chain locus and is therefore activated in B cell malignancies (2). It has also been shown that post-translational modification of Bcl-2, phosphorylation at serine 70, may be required to render its full and/or enhanced anti-apoptotic effect (3, 4).

Bioinformatics

Entrez Mouse
Rat
Human
Uniprot Human
Human
Human
Human
Human
Human
Mouse
Alternate Names
  • apoptosis regulator Bcl-2
  • B-cell CLL/lymphoma 2
  • Bcl-2

Research Areas for Bcl-2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Autophagy
Cancer
Cellular Markers
Phospho-Specific
Tumor Suppressors