Bcl-2 Products

Bcl-2 Antibody
Bcl-2 Antibody
Species: Hu, Mu, Rt, Ca, Po, Bv, Fe
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Bcl-2 Antibody (625509) [Unco ...
Bcl-2 Antibody (625509) [Unconjuga...
Species: Hu, Mu, Rt
Applications: WB, IHC, KO
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
Bcl-2 Antibody [Unconjugated] ...
Bcl-2 Antibody [Unconjugated]
Species: Hu, Mu
Applications: WB, Simple Western, IHC, IP
Host: Goat Polyclonal
Formulation Catalog # Availability Price  
Human Total Bcl-2 DuoSet IC E ...
Human Total Bcl-2 DuoSet IC ELISA,...
Species: Hu
Applications: ELISA
Conjugate Catalog # Availability Size Price
Human Bcl-2 ELISA Kit (Colori ...
Human Bcl-2 ELISA Kit (Colorimetric)
Species: Hu
Applications: ELISA
Recombinant Human Bcl-2 Prote ...
Recombinant Human Bcl-2 Protein
Species: Hu
Applications: Func, PAGE
Recombinant Human Bcl-2 (minu ...
Recombinant Human Bcl-2 (minus C-T...
Species: Hu
Applications: Inhibition Activity
Formulation Catalog # Availability Price  
Bcl-2 Recombinant Protein Ant ...
Bcl-2 Recombinant Protein Antigen
Species: Hu
Applications: AC


The Bcl-2 family of proteins regulate apoptosis by controlling mitochondrial permeability and release of cytochrome c. Bcl-2 is an anti-apoptotic protein that resides in the outer mitochondrial wall and inhibits release of cytochrome c (1). Over-expression of Bcl-2 has been shown to promote cell survival by suppressing apoptosis. It has been documented that bcl-2 becomes deregulated in tumor cells as a result of translocation into the immunoglobulin heavy-chain locus and is therefore activated in B cell malignancies (2). It has also been shown that post-translational modification of Bcl-2, phosphorylation at serine 70, may be required to render its full and/or enhanced anti-apoptotic effect (3, 4).


Entrez Human
Uniprot Human
Product By Gene ID 596
Alternate Names
  • apoptosis regulator Bcl-2
  • Bcl-2
  • B-cell CLL/lymphoma 2

Research Areas for Bcl-2

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
Tumor Suppressors

Bioinformatics Tool for Bcl-2

Discover related pathways, diseases and genes to Bcl-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Related Bcl-2 Blog Posts

Check out the latest blog posts on Bcl-2.

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Losing memory: Toxicity from mutant APP and amyloid beta explain the hippocampal neuronal damage in Alzheimer's disease
 By Jamshed Arslan Pharm.D.  Alzheimer's disease (AD) is an irreversible brain disorder that destroys memory and thinking skills. The telltale signs of AD brains are extracellular deposits of amy...    Read more.
Autophagy independent roles of the core ATG proteins
By Christina Towers, PhD. Autophagy and ATG ProteinsAutophagy is a nutrient recycling process that cells use to fuel metabolism, particularly in response to nutrient deprivation.  It is critical for removal of dam...    Read more.
Key Targets in Apoptosis, Necroptosis, and Autophagy
Cell death/recycling pathways such as apoptosis, necroptosis, and autophagy are an integral part of the growth, development, homeostasis as well as the pathophysiology in the life of living organisms. These signaling pathways are highly regulated and...    Read more.
Altered expression of BCL2 in cancer
Similar to other cell processes, the balance between cell survival and cell death is an important equilibrium that when altered expression of genes can lead to a variety of disease.  For example, too little cell death can promote cell overgrowth a...    Read more.
MAPK8/JNK1 - A multifunctional kinase and drug target for cancer therapeutics
The c-Jun N-terminal kinase (JNK) family is a group of regulatory kinases with important functions in cell morphogenesis, inflammation, differentiation, and cell death (1). Aberrant activation of JNK family proteins in cancers has led to interest i...    Read more.
p53 - Investigating an important tumor suppressor
p53 is a tumor suppressor that has a central role in regulating cell cycle arrest, DNA repair, and apoptosis. p53 is widely studied for its role in cancer and is mutated or altered in more than half of all cancers (1). This widespread role in tumor...    Read more.
Bcl-2 - an antiapoptotic protein with an important role in cancer cell survival
B-cell lymphoma 2 (Bcl-2) protein is an oncogene that normally acts as an apoptotic inhibitor and localizes to the mitochondrial membrane where it prevents the release of cytochrome c. The Bcl-2 protein family consists of over 20 proteins each co...    Read more.
Beclin 1 - a key regulator of autophagosome formation
The Beclin 1 protein is a central regulator of autophagy in mammalian cells. Autophagy is an essential process used to maintain cellular homeostasis by degrading and recycling cellular components such as damaged or worn out organelles and macromole...    Read more.
BNIP3 - a regulator of mitochondrial autophagy and cell death
Bcl-2 nineteen-kilodalton interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein. BNIP3 localizes to the mitochondrial membrane where it plays a key role in mitochondrial autophagy and cell death pathways. Similar to other Bcl-2 family m...    Read more.
BAG3 - Hsp70 is my friend!
The BAG proteins are a large family of chaperone regulators governing a wide range of cell processes such as proliferation, survival, stress response, tumorigenesis, neuronal differentiation, growth arrest and apoptosis as reviewed in Takayama et al1....    Read more.
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