Bcl-2 Products

Antibodies
Bcl-2 Antibody
Bcl-2 Antibody
NB100-56098
Species: Hu, Mu, Rt, Ca, Po, Bv, Fe
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Bcl-2 Antibody
Bcl-2 Antibody
NB100-56101
Species: Hu, Mu, Rt, Ca, Ge
Applications: WB, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
Bcl-2 Antibody [Unconjugated] ...
Bcl-2 Antibody [Unconjugated]
AF810
Species: Hu, Mu
Applications: WB, Simple Western, IHC, IP
Host: Goat Polyclonal
Formulation Catalog # Availability Price  
ELISA Kits
Mouse Bcl-2 ELISA Kit (Colori ...
Mouse Bcl-2 ELISA Kit (Colorimetric)
NBP2-69946
Species: Mu
Applications: ELISA
Rat Bcl-2 ELISA Kit (Colorime ...
Rat Bcl-2 ELISA Kit (Colorimetric)
NBP2-69947
Species: Rt
Applications: ELISA
Human Bcl-2 ELISA Kit (Colori ...
Human Bcl-2 ELISA Kit (Colorimetric)
NBP1-91188
Species: Hu
Applications: ELISA
Lysates
Bcl-2 Knockout HeLa Cell Lysa ...
Bcl-2 Knockout HeLa Cell Lysate
NBP2-64941
Species: Hu
Applications: WB
Bcl-2 Knockout HeLa Cell Lysa ...
Bcl-2 Knockout HeLa Cell Lysate
NBP2-78561
Species: Hu
Proteins
Recombinant Human Bcl-2 Prote ...
Recombinant Human Bcl-2 Protein
NBP2-34889
Species: Hu
Applications: Func, PAGE, Bioactivity
Recombinant Human Bcl-2 (minu ...
Recombinant Human Bcl-2 (minus C-T...
827-BC
Species: Hu
Applications: Inhibition Activity
Formulation Catalog # Availability Price  
Bcl-2 Recombinant Protein Ant ...
Bcl-2 Recombinant Protein Antigen
NBP2-58567PEP
Species: Hu
Applications: AC

Description

The Bcl-2 family of proteins regulate apoptosis by controlling mitochondrial permeability and release of cytochrome c. Bcl-2 is an anti-apoptotic protein that resides in the outer mitochondrial wall and inhibits release of cytochrome c (1). Over-expression of Bcl-2 has been shown to promote cell survival by suppressing apoptosis. It has been documented that bcl-2 becomes deregulated in tumor cells as a result of translocation into the immunoglobulin heavy-chain locus and is therefore activated in B cell malignancies (2). It has also been shown that post-translational modification of Bcl-2, phosphorylation at serine 70, may be required to render its full and/or enhanced anti-apoptotic effect (3, 4).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Mouse
Product By Gene ID 596
Alternate Names
  • apoptosis regulator Bcl-2
  • Bcl-2
  • B-cell CLL/lymphoma 2

Research Areas for Bcl-2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Autophagy
Cancer
Cellular Markers
Phospho-Specific
Tumor Suppressors

Bioinformatics Tool for Bcl-2

Discover related pathways, diseases and genes to Bcl-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related Bcl-2 Blog Posts

Check out the latest blog posts on Bcl-2.
Losing memory: Toxicity from mutant APP and amyloid beta explain the hippocampal neuronal damage in Alzheimer's disease
By Jamshed Arslan Pharm.D. Alzheimer's disease (AD) is an irreversible brain disorder that destroys memory and thinking skills. The telltale signs of AD brains are extracellular deposits of amyloid beta (a polypepti...    Read more.
Autophagy independent roles of the core ATG proteins
By Christina Towers, PhD. Autophagy and ATG ProteinsAutophagy is a nutrient recycling process that cells use to fuel metabolism, particularly in response to nutrient deprivation.  It is critical for removal of dam...    Read more.
Key Targets in Apoptosis, Necroptosis, and Autophagy
Cell death/recycling pathways such as apoptosis, necroptosis, and autophagy are an integral part of the growth, development, homeostasis as well as the pathophysiology in the life of living organisms. These signaling pathways are highly regulated and...    Read more.
Altered expression of BCL2 in cancer
Similar to other cell processes, the balance between cell survival and cell death is an important equilibrium that when altered expression of genes can lead to a variety of disease.  For example, too little cell death can promote cell overgrowth a...    Read more.
MAPK8/JNK1 - A multifunctional kinase and drug target for cancer therapeutics
The c-Jun N-terminal kinase (JNK) family is a group of regulatory kinases with important functions in cell morphogenesis, inflammation, differentiation, and cell death (1). Aberrant activation of JNK family proteins in cancers has led to interest i...    Read more.
p53 - Investigating an important tumor suppressor
p53 is a tumor suppressor that has a central role in regulating cell cycle arrest, DNA repair, and apoptosis. p53 is widely studied for its role in cancer and is mutated or altered in more than half of all cancers (1). This widespread role in tumor...    Read more.
Bcl-2 - an antiapoptotic protein with an important role in cancer cell survival
B-cell lymphoma 2 (Bcl-2) protein is an oncogene that normally acts as an apoptotic inhibitor and localizes to the mitochondrial membrane where it prevents the release of cytochrome c. The Bcl-2 protein family consists of over 20 proteins each co...    Read more.
Beclin 1 - a key regulator of autophagosome formation
The Beclin 1 protein is a central regulator of autophagy in mammalian cells. Autophagy is an essential process used to maintain cellular homeostasis by degrading and recycling cellular components such as damaged or worn out organelles and macromole...    Read more.
BNIP3 - a regulator of mitochondrial autophagy and cell death
Bcl-2 nineteen-kilodalton interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein. BNIP3 localizes to the mitochondrial membrane where it plays a key role in mitochondrial autophagy and cell death pathways. Similar to other Bcl-2 family m...    Read more.
BAG3 - Hsp70 is my friend!
The BAG proteins are a large family of chaperone regulators governing a wide range of cell processes such as proliferation, survival, stress response, tumorigenesis, neuronal differentiation, growth arrest and apoptosis as reviewed in Takayama et al1....    Read more.
Read more Bcl-2 related blogs.