Apolipoprotein E R2/ApoE R2 Antibody

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Western Blot: Apolipoprotein E R2/ApoE R2 Antibody [NB100-2216] - Analysis of ApoER2 on mouse brain membrane.
Immunocytochemistry/ Immunofluorescence: Apolipoprotein E R2/ApoE R2 Antibody [NB100-2216] - Antibody was tested in Neuro-2a cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) ...read more

Product Details

Summary
Reactivity Hu, Mu, Ch, BvSpecies Glossary
Applications WB, ICC/IF, PAGE
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Apolipoprotein E R2/ApoE R2 Antibody Summary

Immunogen
A synthetic peptide made to a C-terminal portion of the human ApoER2 protein sequence (between residues 863-963). [UniProt# Q14114]
Localization
Type I membrane. Isoforms that contain the exon encoding for a furin-cleavage site are proteolytically processed, leading to a secreted receptor fragment.
Predicted Species
Bovine (95%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
LRP8
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:200-1:500
  • SDS-Page
Application Notes
This ApoER2 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen at ~106 kDa representing the membrane form of ApoER2. A larger ~130 kDa band may also be seen, representing the glycosylated form of ApoER2. Use in SDS PAGE reported in scientific literature (PMID 27810638).
Publications
Read Publications using
NB100-2216 in the following applications:

  • 1 publication
  • WB
    2 publications

Reactivity Notes

Immunogen has 95% homology to bovine.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Tris-Glycine and 0.15M NaCl
Preservative
0.05% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Apolipoprotein E R2/ApoE R2 Antibody

  • ApoER2
  • APOER2HSZ75190
  • Apolipoprotein E R2
  • Apolipoprotein E receptor 2
  • low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
  • low-density lipoprotein receptor-related protein 8
  • Lr8b
  • LRP8
  • LRP-8
  • MCI1

Background

ApoER2 (apolipoprotein E receptor 2 or LDL receptor related protein 8) is a member of LDL receptor (LDLR) family and it acts as a cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. ApoER2 facilitates extracellular RELN signal transduction to intracellular signaling processes, mainly through binding with DAB1 on its cytoplasmic tail. RELN acts via both VLDLR and ApoER2 to regulate tyrosine phosphorylation mediated DAB1 activation and microtubule function in neuronal cells. ApoER2 possess higher affinity for RELN compared to VLDLR and is therefore, a key player in Reelin pathway that governs forebrain's neuronal layering during prenatal brain development. ApoER2 associates with ER resident receptor-associated protein (RAP) as well as with dimers of beta 2-glycoprotein I. In the vasculature, ApoER2 has been suggested to implicate in suppressing platelet aggregation. Moreover, ApoER2 is highly expressed in epididymis (initial segment), where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), which are required for sperm maturation. ApoER2 also function as an endocytic receptor and defective ApoER2 have been linked to myocardial infarction type 1 (MCI1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Apolipoprotein E R2/ApoE R2 Antibody (NB100-2216)(3)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: PAGE, WB.


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PAGE
(1)
WB
(2)
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Filter By Species
Human
(1)
Mouse
(1)
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Showing Publications 1 - 3 of 3.
Publications using NB100-2216 Applications Species
Pillay S, Zou W, Cheng F et al. AAV serotypes have distinctive interactions with domains of the cellular receptor AAVR J. Virol. 2017 Jul 05 [PMID: 28679762] (WB, Human) WB Human
Wang W, Moerman-Herzog AM, Slaton A, Barger SW Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2. Neurobiol. Aging Oct 11 2016 [PMID: 27810638] (PAGE, WB, Mouse) PAGE, WB Mouse
Ding J, Bowes R C. Synaptic Expression of Apoer2 in the Plexiform Layers of Mouse Retina. 2008 Annual Meeting of the Association for Research in Vision Ophthalmology (ARVO); Fort Lauderdale, FL; USA. 27-Apr-08.

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Product General Protocols

View specific protocols for Apolipoprotein E R2/ApoE R2 Antibody (NB100-2216): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Apolipoprotein E R2/ApoE R2 Antibody (NB100-2216) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB100-2216AF405
Alexa Fluor 488 Labeled NB100-2216AF488
Alexa Fluor 647 Labeled NB100-2216AF647
Alexa Fluor 700 Labeled NB100-2216AF700
Biotin Labeled NB100-2216B
DyLight 405 Labeled NB100-2216V
DyLight 488 Labeled NB100-2216G
DyLight 550 Labeled NB100-2216R
DyLight 650 Labeled NB100-2216C
FITC Labeled NB100-2216F
HRP Labeled NB100-2216H

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Bioinformatics

Gene Symbol LRP8
Entrez