Reelin Antibody [Unconjugated]

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Reelin was detected in immersion fixed frozen sections of mouse embryo (13 d.p.c.) using Goat Anti-Mouse Reelin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3820) at 1.7 µg/mL overnight at 4 °C. Tissue ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

Reelin Antibody [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Reelin
Ala27-Met862
Accession # Q60841
Specificity
Detects mouse Reelin in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
RELN
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • Immunohistochemistry 5-15 ug/mL
Publications
Read Publications using
AF3820 in the following applications:

  • ICC
    1 publication
  • IHC
    3 publications
  • 1 publication

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Reelin Antibody [Unconjugated]

  • EC 3.4.21
  • EC 3.4.21.-
  • Reeler
  • Reelin
  • RELN
  • RL
  • RLPRO1598

Background

Reelin is a 400 kDa, extracellular matrix glycoprotein secreted by several neurons. It is a serine protease that degrades fibronectin and laminin. Reelin also binds lipoprotein receptor superfamily members APOER2 and VLDLR which transduce signals important for neuronal positioning during brain development and synaptic plasticity in the adult brain. In vivo, Reelin undergoes proteolytic processing at two sites, generating three Reelin fragments. The N-terminal domain binds integrin alpha 3/ beta 1, leading to a disruption of neuronal glial cell interactions and inhibition of neuronal migration. Mouse Reelin shares 94% and 96% amino acid identity with human and rat Reelin, respectively in the region immunized.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Reelin Antibody (AF3820)(5)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: ICC, IHC, IHC-P.


Filter By Application
ICC
(1)
IHC
(3)
IHC-P
(1)
All Applications
Filter By Species
Mouse
(5)
All Species
Showing Publications 1 - 5 of 5.
Publications using AF3820 Applications Species
MF Mehler, JR Petronglo, EE Arteaga-Br, M Gulinello, ML Winchester, N Pichamoort, SK Young, CD DeJesus, H Ishtiaq, S Gokhan, AE Molero Loss-of-huntingtin in medial and lateral ganglionic lineages differentially disrupts regional interneuron and projection neuron subtypes and promotes Huntington's disease-associated behavioral, cellular and pathological hallmarks J. Neurosci., 2019;0(0):. 2019 [PMID: 30626701] (IHC, Mouse) IHC Mouse
H Ogino, A Hisanaga, T Kohno, Y Kondo, K Okumura, T Kamei, T Sato, H Asahara, H Tsuiji, M Fukata, M Hattori Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin J. Neurosci, 2017;0(0):. 2017 [PMID: 28213441] (IHC, Mouse) IHC Mouse
Kohno T, Honda T, Kubo K, Nakano Y, Tsuchiya A, Murakami T, Banno H, Nakajima K, Hattori M Importance of Reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis. J Neurosci, 2015;35(11):4776-87. 2015 [PMID: 25788693] (IHC-P, Mouse) IHC-P Mouse
Koie, Mari, Okumura, Kyoko, Hisanaga, Arisa, Kamei, Takana, Sasaki, Kazutomo, Deng, Mengyan, Baba, Atsushi, Kohno, Takao, Hattori, Mitsuhar Cleavage within Reelin repeat 3 regulates the duration and range of the signaling activity of Reelin protein. J Biol Chem, 2014;289(18):12922-30. 2014 [PMID: 24644294] (ICC, Mouse) ICC Mouse
Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation. J. Cell Biol., 2012;197(6):837-49. 2012 [PMID: 22665518] (IHC, Mouse) IHC Mouse

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Bioinformatics

Gene Symbol RELN
Uniprot
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