Species: Hu, Mu, Ch, Bv
Applications: WB, ICC/IF, PAGE
Host: Rabbit Polyclonal
Species: Hu, Mu, Bv, Ch
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: Binding Activity
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Apolipoprotein E Receptor 2 (ApoER2), also known as LRP8, is a Low-density lipoprotein receptor family member involved in endocytosis and signal transduction. Specifically, ApoER-2 is responsible for the cellular recognition and internalization of ApoE containing lipoproteins, including VLDL and HDL.
ApoER2 is expressed mainly in the brain, placenta, platelets and megakaryocytic cells, but not in the liver. LRP8 mutations can cause myocardial infarction type 1 (MCI1), a condition characterized by the irreversible necrosis of heart muscle secondary to prolonged ischemia. ApoER2 may also play a role in debilitating neurodegenerative diseases such as schizophrenia and Alzheimer's disease.
ApoER2 antibodies are useful tools for studying certian cardiac and neurodegenerative diseases.
Bioinformatics
| Entrez |
Mouse
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
7804 |
| Alternate Names |
- APOER2HSZ75190
- Apolipoprotein E receptor 2
- low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
- low-density lipoprotein receptor-related protein 8
- LRP-8
- MCI1
|
