LRP-1 Antibody (A2Mr alpha-2) - BSA Free

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Immunohistochemistry: LRP-1 Antibody (A2Mr alpha-2) [NB100-64808] - Immunoperoxidase staining of a human tonsil cryosection with Mouse anti Human CD91 antibody, clone A2Mr alpha-2 followed by the Histar detection ...read more
Immunohistochemistry: LRP-1 Antibody (A2Mr alpha-2) [NB100-64808] - Immunoperoxidase staining of a human tonsil cryosection with Mouse anti Human CD91 antibody, clone A2Mr alpha-2 followed by the Histar detection ...read more
Immunohistochemistry: LRP-1 Antibody (A2Mr alpha-2) [NB100-64808] - Immunoperoxidase staining of a human tonsil cryosection with Mouse anti Human CD91 antibody, clone A2Mr alpha-2 followed by the Histar detection ...read more
Immunohistochemistry: LRP-1 Antibody (A2Mr alpha-2) [NB100-64808] - Immunoperoxidase staining of a human tonsil cryosection with Mouse anti Human CD91 antibody, clone A2Mr alpha-2 followed by the Histar detection ...read more
Immunofluorescence: LRP-1 Antibody (A2Mr alpha-2) [NB100-64808] - Staining of a human tonsil cryosection with Mouse anti Human CD91 antibody, clone A2Mr alpha-2, red in A and Mouse anti Human CD21, clone LB21, green in ...read more
Immunofluorescence: LRP-1 Antibody (A2Mr alpha-2) [NB100-64808] - Staining of a human tonsil cryosection with Mouse anti Human CD91 antibody, clone A2Mr alpha-2, red in A and Mouse anti Human CD21, clone LB21, green in ...read more
Immunofluorescence: LRP-1 Antibody (A2Mr alpha-2) [NB100-64808] - Staining of a human tonsil cryosection with Mouse anti Human CD91 antibody, clone A2Mr alpha-2, red in A and Mouse anti Human CD21, clone LB21, green in ...read more
Reduced EHD1 recruitment to endosomes upon EHD4 knock-down.A-F, Representative micrographs and insets depicting EHD1-GFP recruitment to endosomes in untreated (A and inset in D), mock-treated (B and inset in E), and ...read more
Increased sorting endosome size and decreased EHD1 recruitment upon Rabenosyn-5 knock-down.A-L, Representative micrographs and insets depicting EEA1-labeled endosomes and EHD1-GFP in mock-treated and Rabenosyn-5 ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, Flow, IHC, IP, ICC/IF
Clone
A2Mr alpha-2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Format
BSA Free
Concentration
1.0 mg/ml

Order Details

LRP-1 Antibody (A2Mr alpha-2) - BSA Free Summary

Additional Information
Clone A2Mr alpha-2 was used by HLDA to establish CD designation.
Immunogen
Purified alpha2 macroglobulin receptor
Specificity
Recognises an epitope in the extracellular region of the 500kD alpha chain.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
LRP1
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA Direct
  • Flow Cytometry 1:50-1:100
  • Immunofluorescence
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunoprecipitation 1:10-1:500
  • Western Blot Non-reducing conditions
Application Notes
For Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Use non-reducing conditions for western blot.
Control
LRP-1 Overexpression Lysate
Publications
Read Publications using
NB100-64808 in the following applications:

Reactivity Notes

Use in Mouse reported in scientific literature (PMID:32966336).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for LRP-1 Antibody (A2Mr alpha-2) - BSA Free

  • A2MR
  • Alpha-2-Macroglobulin Receptor
  • APOER
  • Apolipoprotein E receptor
  • APR
  • CD91 antigen
  • CD91
  • EC 1.1.1.94
  • EC 3.4.21.9
  • IGFBP3R
  • low density lipoprotein receptor-related protein 1
  • LRP
  • LRP-1
  • LRP1A
  • prolow-density lipoprotein receptor-related protein 1
  • TbetaR-V/LRP-1/IGFBP-3 receptor
  • TGFBR5
  • type V tgf-beta receptor

Background

Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signalling, neuronal calcium signalling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for LRP-1 Antibody (NB100-64808)(3)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Blogs on LRP-1.

Detecting HIF alpha and beyond: Best controls for hypoxia Western blot analysis
By Rosa Moreno, PhD. Detecting HIF alpha and beyond: Best controls for hypoxia Western blot analysisPhysiological low levels of oxygen induce normal hypoxic events across biological systems. This hypoxic state activ...  Read full blog post.

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Bioinformatics

Gene Symbol LRP1