Angiopoietin-2 Antibody [DyLight 488]

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: DyLight 488

Angiopoietin-2 Antibody [DyLight 488] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant mouse Angiopoietin-2
  Asp68-Phe496
  Accession # O35608
• Specificity: Detects mouse Angiopoietin-2 in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant human Angiopoietin-2, recombinant mouse (rm) Angiopoietin-1, and rmAngiopoietin-3 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: ANGPT2
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Angiopoietin-2 Antibody [DyLight 488]

• AGPT2
• ANG2
• ANG-2
• angiopoietin 2
• Angiopoietin-2
• angiopoietin-2a
• angiopoietin-2B
• angiopoitin 2
• ANGPT2
• Tie2-ligand

Background

Angiopoietin 1 and Angiopoietin 2 are important for development of the endothelium, by regulating tyrosine phosphorylation of the membrane receptor Tie 2/Tek. Angiopoietin 2 is only 60% homologous with Angiopoietin 1. Angiopoietin 1 binding to Tie 2/Tek causes phosphorylation of the receptor. Angiopoietin 2 competes for this binding, and thus blocks receptor phosphorylation. Angiopoietin 2 expression occurs at sites of vascular remodeling: dorsal aorta and major aortic branches, ovary, placenta and uterus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ANGPT2