Als2 Antibody

Product Discontinued

Als2 Antibody Summary

• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 272 of Alsin (Uniprot ID#Q96Q42)
• Localization: Cytoplasm
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ALS2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:100-1:2000

Reactivity Notes

Tested in human. Not yet tested in any other species.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
• Preservative: 0.01% Thimerosal
• Purity: Immunogen affinity purified

Alternate Names for Als2 Antibody

• ALS2CR6
• alsin
• ALSJ
• amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 6
• amyotrophic lateral sclerosis 2 (juvenile)
• Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein
• Amyotrophic lateral sclerosis 2 protein
• FLJ31851
• IAHSP
• KIAA1563
• MGC87187
• PLSJ

Background

The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ALS2