MyD88 Antibody

Interleukin-1 (IL-1)-induced activation of the NFkappaB pathway is mediated through the IL-1 receptor and the subsequent phosphorylation of IL-1 receptorassociated kinase (IRAK). The myeloid differentiation protein MyD88 was originally characterized as a protein upregulated in myeloleukemic cells following IL-6-induced growth arrest and terminal differentiation. MyD88 is now known to function as an adaptor protein for the association of IRAK with the IL-1 receptor. MyD88 is functionally homologous to the adaptor protein tube in the Toll signaling pathway of Drosophilia, and both proteins are members of the Toll/IL-1R superfamily. MyD88 contains a characteristic N-terminal death domain that is essential for NFkappaB activation and an adjacent Toll/IL-1R homology domain (TIR domain). Collectively, these domains enable the protein-protein interactions of MyD88 with IRAK and the IL-1 receptor complex.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 3 applications: IF/IHC, IHC-P, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP1-19785	Applications	Species
Block MS, Vierkant RA, Rambau PF et al. MyD88 and TLR4 Expression in Epithelial Ovarian Cancer. Mayo Clin. Proc. 2018-03-01 [PMID: 29502561] (IF/IHC, Human)	IF/IHC	Human
Gao T, Zhang SP, Wang JF et al. TLR3 contributes to persistent autophagy and heart failure in mice after myocardial infarction J. Cell. Mol. Med. 2017-09-25 [PMID: 28945004] (WB, Mouse)	WB	Mouse
Dalvi Pranjali, Sun Bing, Tang Norina, Pulliam Lynn. Immune activated monocyte exosomes alter microRNAs in brain endothelial cells and initiate an inflammatory response through the TLR4/MyD88 pathway. Sci Rep 2017-01-01 [PMID: 28855621] (WB, Human)	WB	Human
Tian J, Guo X, Liu XM et al. Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes. Cardiovasc Res. 2013-06-01 [PMID: 23447644] (WB, Rat)	WB	Rat
Mijares Lilia A, Wangdi Tamding, Sokol Caroline et al. Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. Journal of Immunology (Baltimore, Md. : 1950) 2011-01-01 [PMID: 21572023] (IHC-P, Mouse)	IHC-P	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Li Lin	IP	Rat	07/19/2011	View Summary Application Immunoprecipitation Sample Tested H9c2 whole cell lysate Species Rat Lot 361156

Array NBP1-19785

• MyD88 Antibodies
• MyD88 ELISA Kit
• MyD88 Inhibitor
• MyD88 Lysate
• MyD88 Proteins
• MyD88 ELISA