Myelin Protein Zero Antibody


Immunocytochemistry/ Immunofluorescence: Myelin Protein Zero Antibody [NB100-1607] - Immunohistochemical staining of P-zero on a 4.0% paraformaldehyde-fixed, paraffin-embedded tissue section through the sciatic nerve of more
Immunohistochemistry: Myelin Protein Zero Antibody [NB100-1607] - In the image (a lower power tissue section through an adult sciatic nerve), Myelin Protein Zero (brown staining) can be seen in all of the myelinating more

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IP
0.2 mg/ml

Order Details

Myelin Protein Zero Antibody Summary

Chickens were immunized with two synthetic peptide/keyhole limpet hemocyanin (KLH) conjugates. These synthetic peptides corresponded to different regions of Myelin Protein Zero, but are shared between the human (NP_000521, NCBI) and mouse (NP_032649, NCBI) sequences.
Schwann Cell Marker
Immunogen affinity purified
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  • Immunocytochemistry/Immunofluorescence 1:10 - 1:500
  • Immunohistochemistry 1:10-1:500
  • Immunoprecipitation
  • Western Blot 1:10000-1:20000
Application Notes
Both of these anti-peptide antibodies were analyzed by immunohistochemistry (1:2000) using fluorescein-labeled goat anti-chicken IgY (1:500) as the secondary reagent. Western Blot reactivity reported in scientific literature (PMID: 22689911). Use in immunoprecipitation reported in scientific literature (PMID:26406915).
Theoretical MW
27 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publications using
NB100-1607 in the following applications:

  • 5 publications
  • IHC
    1 publication
  • IP
    1 publication
  • WB
    2 publications

Reactivity Notes

Human, Mouse reactivity reported in scientific literature (PMID: 26406915), Rat reactivity reported in scientific literature (PMID: 22511272).

Packaging, Storage & Formulations

Store at 4C in the dark.
10mM Sodium PBS (0.9% isotonic, w/v, pH 7.2)
0.02% Sodium Azide
0.2 mg/ml
Immunogen affinity purified


Chicken products cannot be exported to Canada.

Purification Notes
After repeated injections, immune eggs were collected, and the IgY fractions were purified from the yolks. These IgY fractions were then affinity-purified using a peptide column, and the concentrations of the eluates adjusted to 200 ug/ml. Finally, equal volumes of both of these affinitypurified anti-peptide antibodies were mixed, and the preparation was filter-sterilized.

Storage Notes
Store at 4C in the dark. Under these conditions, the antibodies should have a shelf life of at least 12 months (provided they remain sterile). Do not freeze these antibodies unless you want to store them for longer periods of time. Note, however, that each time an antibody preparation is frozen, about half of its binding activity is lost.

Alternate Names for Myelin Protein Zero Antibody

  • Charcot-Marie-Tooth neuropathy 1B
  • CHM
  • CMT1
  • CMT1B
  • CMT2I
  • CMT2J
  • CMT4E
  • CMTDI3
  • MPP
  • Myelin peripheral protein
  • myelin protein P0
  • myelin protein zeroDSS
  • P0


Myelin Protein Zero encodes a major structural protein of peripheral myelin. Mutations in this gene result in the autosomal dominant form of Charcot-Marie-Tooth disease type 1 as other polyneuropathies. [provided by RefSeq]


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Myelin Protein Zero Antibody (NB100-1607)(9)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: ICC/IF, IHC, IP, WB.

Filter By Application
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Showing Publications 1 - 9 of 9.
Publications using NB100-1607 Applications Species
Chen R, Yang X, Zhang B et al. EphA4 Negatively Regulates Myelination by Inhibiting Schwann Cell Differentiation in the Peripheral Nervous System Front Neurosci Nov 13 2019 [PMID: 31798398] (WB, ICC/IF, Rat) WB, ICC/IF Rat
Su W, Gu Y, Wei Z et al. Rab27a/Slp2-a complex is involved in Schwann cell myelination. Neural Regeneration Research. Dec 9 2016 [PMID: 28123429] (ICC/IF, Rat) ICC/IF Rat
Brugger V, Engler S, Pereira JA et al. HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins. PLoS Biol. 2015 Sep 01 [PMID: 26406915] (ICC/IF, IP, Human, Mouse) ICC/IF, IP Human, Mouse
Martinez-Vega R, Garrido F, Partearroyo T et al. Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism. FASEB J. 2014 Nov 10 [PMID: 25384423]
Saporta MA, Shy BR, Patzko A et al. MpzR98C arrests Schwann cell development in a mouse model of early-onset Charcot-Marie-Tooth disease type 1B Brain 2012 Jun 10 [PMID: 22689911] (WB, IHC, ICC/IF, Mouse) WB, IHC, ICC/IF Mouse
Hossain S, de la Cruz-Morcillo MA, Sanchez-Prieto R, Almazan G. Mitogen-activated protein kinase p38 regulates krox-20 to direct schwann cell differentiation and peripheral myelination. Glia;60(7):1130-44. 2012 Jul. [PMID: 22511272] (ICC/IF, Rat) ICC/IF Rat
Asada N, Takase M, Nakamura J et al. Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice. The Journal of Clinical Investigation. 2011 Sep 12. [PMID: 21911936]
Wang G, Yin W, Shin H Et al. Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome Nature Aging Nov 1 2021
Malheiro A Investigating the effect of phosphodiesterase-4 (PDE4) inhibitors on Schwann cells myelination in a 3D regeneration model and in a hyperglycemia model Book Jun 2 2021

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Product General Protocols

View specific protocols for Myelin Protein Zero Antibody (NB100-1607): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Myelin Protein Zero Antibody (NB100-1607). (Showing 1 - 1 of 1 FAQs).

  1. Does this antibody target the extracellular domain of the protein?
    • Two different peptides were used to raise this antibody: 1) the first peptide sequence is located in the amino-terminal half of the protein and is located within an "Immunoglobulin V-type" domain, which is extracellular. 2) The second peptide sequence is located near the C-terminus of the protein (cytoplasmic). The antibody recognizes MPZ protein, when both antigens are available but we do not know how strong would be the signal if only extracellular antigen is visible.

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Gene Symbol MPZ