XPD Antibody (OTI4B11) [PE]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: OTI4B11
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: PE

XPD Antibody (OTI4B11) [PE] Summary

• Immunogen: Human recombinant protein fragment corresponding to amino acids 78-307 of human ERCC2 (NP_000391) produced in E.coli.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: XPD
• Purity: >95%

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: >95%

Alternate Names for XPD Antibody (OTI4B11) [PE]

• Basic transcription factor 2 80 kDa subunit
• BTF2 p80
• COFS2
• CXPD
• DNA excision repair protein ERCC-2
• DNA repair protein complementing XP-D cells
• EC 3.6.1
• EC 3.6.4.12
• EM9
• EM9TFIIH basal transcription factor complex 80 kDa subunit
• ERCC2
• excision repair cross-complementing rodent repair deficiency, complementationgroup 2
• MAG
• MGC102762
• MGC126218
• MGC126219
• TFIIH 80 kDa subunit
• TFIIH basal transcription factor complex helicase subunit
• TFIIH basal transcription factor complex helicase XPD subunit
• TTD
• xeroderma pigmentosum complementary group D
• Xeroderma pigmentosum group D-complementing protein
• XPD
• XPDC
• XPDTFIIH p80

Background

The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: XPD