XPD Antibody (OTI4B11) [mFluor Violet 610 SE]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: OTI4B11
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: mFluor Violet 610 SE

XPD Antibody (OTI4B11) [mFluor Violet 610 SE] Summary

• Immunogen: Human recombinant protein fragment corresponding to amino acids 78-307 of human ERCC2 (NP_000391) produced in E.coli.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: XPD
• Purity: >95%

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: >95%

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for XPD Antibody (OTI4B11) [mFluor Violet 610 SE]

• Basic transcription factor 2 80 kDa subunit
• BTF2 p80
• COFS2
• CXPD
• DNA excision repair protein ERCC-2
• DNA repair protein complementing XP-D cells
• EC 3.6.1
• EC 3.6.4.12
• EM9
• EM9TFIIH basal transcription factor complex 80 kDa subunit
• ERCC2
• excision repair cross-complementing rodent repair deficiency, complementationgroup 2
• MAG
• MGC102762
• MGC126218
• MGC126219
• TFIIH 80 kDa subunit
• TFIIH basal transcription factor complex helicase subunit
• TFIIH basal transcription factor complex helicase XPD subunit
• TTD
• xeroderma pigmentosum complementary group D
• Xeroderma pigmentosum group D-complementing protein
• XPD
• XPDC
• XPDTFIIH p80

Background

The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: XPD