vWF-A1 Antibody (Hu142) [Alexa Fluor™ Plus 594]

• Reactivity: Hu
• Clone: Hu142
• Clonality: Monoclonal
• Host: Llama
• Conjugate: Alexa Fluor Plus 594

vWF-A1 Antibody (Hu142) [Alexa Fluor™ Plus 594] Summary

• Specificity: VHH antibody detecting vWF-A1
• Clonality: Monoclonal
• Host: Llama

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for vWF-A1 Antibody (Hu142) [Alexa Fluor™ Plus 594]

• vWFA1
• vWF-A1

Background

Caplacizumab is a humanized VHH immunoglobulin that binds to the A1 domain of the large von Willdebrand factor resulting in the inhibition of the interaction of glycoprotein GPIb-IX-V receptor on platelet surface.  The result of neutralizing of the von Willedebrand factor is reduced platelet aggregation.  Caplacizumab has been approved for the treatment of acute thrombotic thrombocytopenic purpura (aTTP), and has been shown to reduce the occurrence of thromboembolic events.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.