Mouse myeloma cell line NS0-derived recombinant human VEGFR2/KDR/Flk-1 Ala20-Glu764 Accession # AAC16450
Detects human VEGFR2/KDR/Flk-1 in ELISAs and Western blots. In sandwich immunoassays, less than 0.5% cross-reactivity with recombinant mouse VEGFR2 is observed and less than 0.2% cross-reactivity with recombinant human (rh) VEGFR3 and rhVEGFR1 is observed.
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Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitute at 0.2 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for VEGFR2/KDR/Flk-1 Antibody [Biotin]
Fetal liver kinase 1
fetal liver kinase-1
FLK1tyrosine kinase growth factor receptor
kinase insert domain receptor (a type III receptor tyrosine kinase)
Kinase insert domain receptor
Protein-tyrosine kinase receptor flk-1
vascular endothelial growth factor receptor 2
VEGFR2 (KDR/Flk-1), VEGFR1 (Flt-1) and VEGFR3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGFR1, 2, and 3 is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis.
VEGFR2 cDNA encodes a 1356 amino acid (aa) residue precursor protein with a 19 aa residue signal peptide. Mature VEGFR2 is composed of a 745 aa residue extracellular domain, a 25 aa residue transmembrane domain and a 567 aa residue cytoplasmic domain. In contrast to VEGFR1 which binds both PlGF and VEGF with high affinity, VEGFR2 binds VEGF but not PlGF with high affinity.
Ferra, N. and R. Davis-Smyth (1997) Endocrine Reviews 18:4.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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