VEGFR2/KDR/Flk-1 Products

Description

Vascular endothelial growth factor receptor 2 (VEGFR2) is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other common growth factor receptors, VEGF receptor 2 dimerises upon ligand binding and is autophosphorylated at multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or can serve as binding sites for SH2 and phosphotyrosine binding containing signaling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity.

Defects in the VEGFR2 gene are associated with susceptibility to benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium called hemangioma capillary infantile. HCI is the most common tumor found in infants, found in up to 10% of all births.

Bioinformatics

Entrez	16542 Mouse 25589 Rat 3791 Human
Uniprot	NM_002253 Human NP_002244 Human NP_002244 Human P35918 Mouse P35968 Human P35968 Human
Product By Gene ID	3791
Alternate Names	CD309 antigen CD309 EC 2.7.10 EC 2.7.10.1 Fetal liver kinase 1 fetal liver kinase-1 FLK-1 FLK1tyrosine kinase growth factor receptor kinase insert domain receptor (a type III receptor tyrosine kinase) Kinase insert domain receptor Protein-tyrosine kinase receptor flk-1 soluble VEGFR2 vascular endothelial growth factor receptor 2 VEGFR VEGFR2 VEGFR-2

Research Areas for VEGFR2/KDR/Flk-1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cellular Markers
Endothelial Cell Markers
Hematopoietic Stem Cell Markers
HIF Target Genes
Hypoxia
Phospho-Specific
Signal Transduction
Stem Cell Markers
Tumor Suppressors
Tyrosine Kinases