VEGFR2/KDR/Flk-1 Products

Antibodies
VEGFR2/KDR/Flk-1 Antibody [Un ...
VEGFR2/KDR/Flk-1 Antibody [Unconju...
AF644
Species: Mu
Applications: WB, Flow, IHC, B/N, CyTOF-ready
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
VEGFR2/KDR/Flk-1 Antibody [Un ...
VEGFR2/KDR/Flk-1 Antibody [Unconju...
AF357
Species: Hu
Applications: WB, IHC, B/N
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
ELISA Kits
Human VEGFR2/KDR/Flk-1 ELISA ...
Human VEGFR2/KDR/Flk-1 ELISA Kit (...
NBP1-83729
Species: Hu
Applications: ELISA
Lysates
VEGFR2/KDR/Flk-1 Overexpressi ...
VEGFR2/KDR/Flk-1 Overexpression Ly...
NBL1-06701
Species: Mu
Applications: WB
Proteins
Recombinant Human VEGFR2/KDR ...
Recombinant Human VEGFR2/KDR Fc Ch...
357-KD
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Mouse VEGFR2/Flk- ...
Recombinant Mouse VEGFR2/Flk-1 Fc ...
443-KD
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  
VEGFR2/KDR/Flk-1 Blocking Pep ...
VEGFR2/KDR/Flk-1 Blocking Peptide
NB100-2382PEP
Species: Hu

Description

Vascular endothelial growth factor receptor 2 (VEGFR2) is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other common growth factor receptors, VEGF receptor 2 dimerises upon ligand binding and is autophosphorylated at multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or can serve as binding sites for SH2 and phosphotyrosine binding containing signaling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity.

Defects in the VEGFR2 gene are associated with susceptibility to benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium called hemangioma capillary infantile. HCI is the most common tumor found in infants, found in up to 10% of all births.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Mouse
Product By Gene ID 3791
Alternate Names
  • fetal liver kinase-1
  • EC 2.7.10
  • EC 2.7.10.1
  • Kinase insert domain receptor
  • Protein-tyrosine kinase receptor flk-1
  • CD309 antigen
  • Fetal liver kinase 1
  • VEGFR-2
  • VEGFR2
  • FLK-1
  • VEGFR
  • vascular endothelial growth factor receptor 2
  • CD309
  • FLK1tyrosine kinase growth factor receptor
  • soluble VEGFR2
  • kinase insert domain receptor (a type III receptor tyrosine kinase)

Research Areas for VEGFR2/KDR/Flk-1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cellular Markers
Endothelial Cell Markers
Hematopoietic Stem Cell Markers
HIF Target Genes
Hypoxia
Phospho-Specific
Signal Transduction
Stem Cell Markers
Tumor Suppressors
Tyrosine Kinases

Bioinformatics Tool for VEGFR2/KDR/Flk-1

Discover related pathways, diseases and genes to VEGFR2/KDR/Flk-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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