VE-Cadherin Antibody [Unconjugated]

Western blot shows lysate of HUVEC human umbilical vein endothelial cells. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Human VE-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF938) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for VE-Cadherin at approximately 125 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

VE-Cadherin was detected in immersion fixed HUVEC human umbilical vein endothelial cells using Goat Anti-Human VE-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF938) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to the plasma membrane. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Simple Western lane view shows lysates of HUVEC human umbilical vein endothelial cells, loaded at 0.2 mg/mL. A specific band was detected for VE‑Cadherin at approximately 162 kDa (as indicated) using 12.5 µg/mL of Goat Anti-Human VE‑Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF938) . This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

• Reactivity: Hu
• Applications: WB, Simple Western, Flow, CyTOF-ready, ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

VE-Cadherin Antibody [Unconjugated] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human VE-Cadherin
  Asp48-Gln593
  Accession # P33151
• Specificity: Detects human VE-Cadherin in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant mouse VE‑Cadherin is observed and less than 5% cross-reactivity with recombinant human E-Cadherin is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: CDH5
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry 2.5 ug/10^6 cells
  • Immunocytochemistry 5-15 ug/mL
  • Simple Western 12.5 ug/mL
  • Western Blot 0.25 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for VE-Cadherin Antibody [Unconjugated]

• 7B4 antigen
• 7B4
• cadherin 5, type 2 (vascular endothelium)
• cadherin 5, type 2, VE-cadherin (vascular epithelium)
• Cadherin-5
• CD144 antigen
• CD144
• CDH5
• endothelial-specific cadherin
• FLJ17376
• Vascular endothelial cadherin
• VECadherin
• VE-Cadherin

Background

Vascular endothelial (VE) - cadherin (VE-CAD), also called 7B4 and cadherin-5, is a member of the cadherin family of cell adhesion molecules. Cadherins are
calcium‑dependent transmembrane proteins which bind to one another in a homophilic manner. On their cytoplasmic side, they associate with the three catenins, alpha , beta , and gamma (plakoglobin). This association links the cadherin protein to the cytoskeleton. Without association with the catenins, the cadherins are non-adhesive. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult. VE-Cadherin has been shown to play important roles in vasculogenesis and angiogenesis. VE-cadherin is a classical cadherin molecule. Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium‑dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. Human VE-cadherin is a 784 amino acid (aa) residue protein with a 25 aa signal sequence and a 759 aa propeptide. The mature protein begins at amino acid 48 and has a 546 aa extracellular domain, a 27 aa transmembrane domain, and a 164 aa cytoplasmic domain. The human and mouse mature VE-CAD proteins share approximately 74% homology.

1. Shimoyama, Y. et al. (1989) J. Cell Biol. 109:1787.
2. Bussemakers, M.J.G. et al. (1993) Mol. Biol. Reports 17:123.
3. Overduin, M. et al. (1995) Science 267:386.
4. Takeichi, M. (1991) Science 251:1451.
5. Nose, A. et al. (1987) EMBO J. 6:3655.
6. Carmeliet, P. et al. (1999) Cell 98:147.
7. Gory-Faure, S. et al. (1999) Development 126:2093.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for VE-Cadherin Antibody (AF938)(66)

Publications using AF938

• Pretorius, L;Ross, KS;Smith, C; Multi-targeted action of rooibos may protect against ischaemic stroke-induced neurological deficit and endothelial dysfunction Journal of ethnopharmacology 2024-09-10 [PMID: 39260709] (Immunohistochemistry, Zebrafish)
• Johnson, D;Colijn, S;Richee, J;Yano, J;Burns, M;Davis, AE;Pham, VN;Saric, A;Jain, A;Yin, Y;Castranova, D;Melani, M;Fujita, M;Grainger, S;Bonifacino, JS;Weinstein, BM;Stratman, AN; Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1 bioRxiv : the preprint server for biology 2024-04-01 [PMID: 38903077] (Immunocytochemistry, Human)
• Essebier, P;Keyser, M;Yordanov, T;Hill, B;Yu, A;Noordstra, I;Yap, AS;Stehbens, SJ;Lagendijk, AK;Schimmel, L;Gordon, EJ; c-Src-induced vascular malformations require localised matrix degradation at focal adhesions Journal of cell science 2024-07-01 [PMID: 38881365] (Western Blot, Human)
• Tian, SP;Ge, JY;Song, YM;Yu, XQ;Chen, WH;Chen, YY;Ye, D;Zheng, YW; A novel efficient strategy to generate liver sinusoidal endothelial cells from human pluripotent stem cells Scientific reports 2024-06-15 [PMID: 38879647] (Immunocytochemistry, Human)
• El Bakkouri, Y;Chidiac, R;Delisle, C;Corriveau, J;Cagnone, G;Gaonac'h-Lovejoy, V;Chin, A;Lécuyer, É;Angers, S;Joyal, JS;Topisirovic, I;Hulea, L;Dubrac, A;Gratton, JP; ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis Nature communications 2024-05-23 [PMID: 38782923] (IF/ICC, Westen Blot, Bovine)
• Goeckel, ME;Lee, J;Levitas, A;Colijn, S;Mun, G;Burton, Z;Chintalapati, B;Yin, Y;Abello, J;Stratman, A; CXCR3-CXCL11 signaling restricts angiogenesis and promotes pericyte recruitment bioRxiv : the preprint server for biology 2023-09-17 [PMID: 37745440] (Immunocytochemistry/ Immunofluorescence, Fish - Danio rerio (Zebrafish))
• Stanton, AE;Bubnys, A;Agbas, E;James, B;Park, DS;Jiang, A;Pinals, RL;Truong, N;Loon, A;Staab, C;Liu, L;Cerit, O;Wen, HL;Kellis, M;Blanchard, JW;Langer, RS;Tsai, LH; Engineered 3D Immuno-Glial-Neurovascular Human Brain Model bioRxiv : the preprint server for biology 2023-08-17 [PMID: 37645757] (IHC, Human)
• Richards, A;Khalil, A;Friesen, M;Whitfield, TW;Lungjangwa, T;Gehrke, L;Mooney, D;Jaenisch, R; SARS-CoV-2 infection of human pluripotent stem cell-derived vascular cells reveals smooth muscle cells as key mediators of vascular pathology during infection bioRxiv : the preprint server for biology 2023-08-07 [PMID: 37609322] (ICC, Human)
• Zhang, H;Kafeiti, N;Lee, S;Masarik, K;Zheng, H;Zhan, H; Unlocking the Role of Endothelial MPL Receptor and JAK2V617F Mutation: Insights into Cardiovascular Dysfunction in MPNs and CHIP bioRxiv : the preprint server for biology 7/13/2023 [PMID: 37503259]
• Choudhury, A;Cady, M;Lucas, C;Najem, H;Phillips, J;Palikuqi, B;Zakimi, N;Joseph, T;Birrueta, J;Chen, W;Bush, N;Hervey-Jumper, S;Klein, O;Toedebusch, C;Horbinski, C;Magill, S;Bhaduri, A;Perry, A;Dickinson, P;Heimberger, A;Ashworth, A;Crouch, E;Raleigh, D; NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy bioRxiv 2023-01-01 [PMID: 37503127] (RNAScope, Human)
• Kho, J;Polak, U;Jiang, MM;Odom, JD;Hunter, JV;Ali, SM;Burrage, LC;Nagamani, SC;Pautler, RG;Thompson, HP;Urayama, A;Jin, Z;Lee, B; Argininosuccinate lyase deficiency causes blood-brain barrier disruption via nitric oxide-mediated dysregulation of claudin expression JCI insight 2023-07-25 [PMID: 37490345] (IHC, Mouse)
• Hong, SG;Ashby, JW;Kennelly, JP;Wu, M;Chattopadhyay, E;Foreman, R;Tontonoz, P;Turowski, P;Gallagher-Jones, M;Mack, JJ; Polarized Mechanosensitive Signaling Domains Protect Arterial Endothelial Cells Against Inflammation bioRxiv : the preprint server for biology 2023-05-26 [PMID: 37292837] (Immunocytochemistry, Human)
• Emy Bosseboeuf, Anissa Chikh, Ahmed Bey Chaker, Tom P. Mitchell, Dhilakshani Vignaraja, Ridhi Rajendrakumar et al. Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow Science Signaling 5/23/2023 [PMID: 37220183]
• Acharya BR, Fang JS, Jeffery ED et al. Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest Life science alliance 8/1/2023 [PMID: 37197981]
• Lisa Bauer, Laurine C Rijsbergen, Lonneke Leijten, Feline FW Benavides, Danny Noack, Mart M Lamers et al. The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells Life Science Alliance 7/1/2023 [PMID: 37072183]
• Jesus M. Gomez-Salinero, Tomer Itkin, Sean Houghton, Chaitanya Badwe, Yang Lin, Viktoria Kalna et al. Cooperative ETS transcription factors enforce adult endothelial cell fate and cardiovascular homeostasis Nature Cardiovascular Research 1/30/2023 [PMID: 36713285]
• M Liu, S Samant, CH Vasa, RM Pedrigi, UM Oguz, S Ryu, T Wei, DR Anderson, DK Agrawal, YS Chatzizisi Co-culture models of endothelial cells, macrophages, and vascular smooth muscle cells for the study of the natural history of atherosclerosis PLoS ONE, 2023-01-20;18(1):e0280385. 2023-01-20 [PMID: 36662769] (ICC, Human)
• Baihui Ma, Tianjiao Li, Wenke Li, Hang Yang, Qixian Zeng, Zihang Pan et al. Patient-specific and gene-corrected induced pluripotent stem cell-derived endothelial cells elucidate single-cell phenotype of pulmonary veno-occlusive disease Stem Cell Reports 12/13/2022 [PMID: 36400028]
• H Kim, K Leng, J Park, AG Sorets, S Kim, A Shostak, RJ Embalabala, K Mlouk, KA Katdare, IVL Rose, SM Sturgeon, EH Neal, Y Ao, S Wang, MV Sofroniew, JM Brunger, DG McMahon, MS Schrag, M Kampmann, ES Lippmann Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin Nature Communications, 2022-11-02;13(1):6581. 2022-11-02 [PMID: 36323693] (IHC, Mouse)
• Luis F. Martins, Ilaria Brambilla, Alessia Motta, Stefano de Pretis, Ganesh Parameshwar Bhat, Aurora Badaloni et al. Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity Neuron 12/21/2022 [PMID: 36240771]
• Luis F. Martins, Ilaria Brambilla, Alessia Motta, Stefano de Pretis, Ganesh Parameshwar Bhat, Aurora Badaloni et al. Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity Neuron 2022-12-21 [PMID: 36240771] (Immunohistochemistry, Mouse)
• AM Schroeder, T Nielsen, M Lynott, G Vogler, AR Colas, R Bodmer Nascent polypeptide-Associated Complex and Signal Recognition Particle have cardiac-specific roles in heart development and remodeling PloS Genetics, 2022-10-14;18(10):e1010448. 2022-10-14 [PMID: 36240221] (ICC, Human)
• Pedro Barbacena, Maria Dominguez-Cejudo, Catarina G. Fonseca, Manuel Gómez-González, Laura M. Faure, Georgia Zarkada et al. Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina Developmental Cell 10/10/2022 [PMID: 36220082]
• Kuo A, Checa A, Niaudet C et al. Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis eLife 2022-10-05 [PMID: 36197001]
• Kuo A, Checa A, Niaudet C et al. Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis eLife 10/5/2022 [PMID: 36197001]
• J Abello, S Raghavan, YY Yien, AN Stratman Peristaltic pumps adapted for laminar flow experiments enhance in vitro modeling of vascular cell behavior The Journal of Biological Chemistry, 2022-08-19;0(0):102404. 2022-08-19 [PMID: 35988646] (ICC, Human)
• Lea C. Steffes, Paul Cheng, Thomas Quertermous, Maya E. Kumar von Willebrand Factor Is Produced Exclusively by Endothelium, Not Neointima, in Occlusive Vascular Lesions in Both Pulmonary Hypertension and Atherosclerosis Circulation 8/2/2022 [PMID: 35914017]
• Jesus Maria Gómez-Salinero, Franco Izzo, Yang Lin, Sean Houghton, Tomer Itkin, Fuqiang Geng et al. Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction Cell Stem Cell 4/1/2022 [PMID: 35364013]
• Lindsey M. Williams, Takashi Fujimoto, Riley R. Weaver, Aric F. Logsdon, Kira M. Evitts, Jessica E. Young et al. Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer’s brain milieu Fluids and Barriers of the CNS 2/5/2022 [PMID: 35123529]
• Nicola Facchinello, Matteo Astone, Matteo Audano, Roxana E. Oberkersch, Marianna Spizzotin, Enrica Calura et al. Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition Nature Metabolism 1/27/2022 [PMID: 35102339]
• André Rosa, Wolfgang Giese, Katja Meier, Silvanus Alt, Alexandra Klaus-Bergmann, Lowell T. Edgar et al. WASp controls oriented migration of endothelial cells to achieve functional vascular patterning Development 2/1/2022 [PMID: 34931661]
• T Barak, E Ristori, AG Ercan-Senc, DF Miyagishim, C Nelson-Wil, W Dong, SC Jin, A Prendergas, W Armero, O Henegariu, EZ Erson-Omay, AS Harmanc?, M Guy, B Gültekin, D Kilic, DK Rai, N Goc, SM Aguilera, B Gülez, S Altinok, K Ozcan, Y Yarman, S Coskun, E Sempou, E Deniz, J Hintzen, A Cox, E Fomchenko, SW Jung, AK Ozturk, A Louvi, K Bilgüvar, ES Connolly, MK Khokha, KT Kahle, K Yasuno, RP Lifton, K Mishra-Gor, S Nicoli, M Günel PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans Nature Medicine, 2021-12-09;27(12):2165-2175. 12/9/2021 [PMID: 34887573]
• Hoai Huong Thi Le, Chen-wei Liu, Philip Denaro, Jordan Jousma, Ning-Yi Shao, Irfan Rahman et al. Genome-wide differential expression profiling of lncRNAs and mRNAs in human induced pluripotent stem cell-derived endothelial cells exposed to e-cigarette extract Stem Cell Research & Therapy 12/4/2021 [PMID: 34863290]
• Megan K. DeBari, Wai Hoe Ng, Mallory D. Griffin, Lauren E. Kokai, Kacey G. Marra, J. Peter Rubin et al. Engineering a 3D Vascularized Adipose Tissue Construct Using a Decellularized Lung Matrix Biomimetics (Basel) 9/18/2021 [PMID: 34562876]
• A Saume, M Thiry, J Defourny LDLR expression in the cochlea suggests a role in endolymph homeostasis and cochlear amplification Hearing research, 2021-07-15;409(0):108311. 2021-07-15 [PMID: 34311268] (IHC, Mouse)
• YG Gete, LW Koblan, X Mao, M Trappio, B Mahadik, JP Fisher, DR Liu, K Cao Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS Aging Cell, 2021-06-04;0(0):e13388. 2021-06-04 [PMID: 34086398] (IHC, Western Blot, Human)
• Athanasios Ziogas, Md Sanaullah Sajib, Jong‐Hyung Lim, Tiago C. Alves, Anupam Das, Anke Witt et al. Glycolysis is integral to histamine‐induced endothelial hyperpermeability The FASEB Journal 3/1/2021 [PMID: 33566443]
• P Mora, PL Hollier, S Guimbal, A Abelanet, A Diop, L Cornuault, T Couffinhal, S Horng, AP Gadeau, MA Renault, C Chapouly Genetic disruption of the Blood Brain Barrier leads to protective barrier formation at the Glia Limitans PLoS Biol, 2020-11-30;18(11):e3000946. 2020-11-30 [PMID: 33253145] (IHC, Human)
• Nicholas E. Propson, Ethan R. Roy, Alexandra Litvinchuk, Jörg Köhl, Hui Zheng Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging Journal of Clinical Investigation 1/4/2021 [PMID: 32990682]
• J Ohmes, Y Xiao, F Wang, MD Mikkelsen, TT Nguyen, H Schmidt, A Seekamp, AS Meyer, S Fuchs Effect of Enzymatically Extracted Fucoidans on Angiogenesis and Osteogenesis in Primary Cell Culture Systems Mimicking Bone Tissue Environment Mar Drugs, 2020-09-21;18(9):. 2020-09-21 [PMID: 32967359] (ICC, Human)
• JW Blanchard, M Bula, J Davila-Vel, LA Akay, L Zhu, A Frank, MB Victor, JM Bonner, H Mathys, YT Lin, T Ko, DA Bennett, HP Cam, M Kellis, LH Tsai Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes Nat. Med., 2020-06-08;26(6):952-963. 2020-06-08 [PMID: 32514169] (ICC, Human)
• Jacquelyn A. Brown, Shannon L. Faley, Yajuan Shi, Kathleen M. Hillgren, Geri A. Sawada, Thomas K. Baker et al. Advances in blood–brain barrier modeling in microphysiological systems highlight critical differences in opioid transport due to cortisol exposure Fluids and Barriers of the CNS 12/1/2020 [PMID: 32493346]
• F Roudnicky, BK Kim, Y Lan, R Schmucki, V Küppers, K Christense, M Graf, C Patsch, M Burcin, CA Meyer, PD Westenskow, CA Cowan Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance Sci Rep, 2020-03-03;10(1):3886. 2020-03-03 [PMID: 32127614] (ICC, Human)
• Paul R. Coleman, Angelina J. Lay, Ka Ka Ting, Yang Zhao, Jia Li, Sorour Jarrah et al. YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment Cell Communication and Signaling 12/1/2020 [PMID: 32013974]
• G Luxán, J Stewen, N Díaz, K Kato, SK Maney, A Aravamudha, F Berkenfeld, N Nagelmann, HC Drexler, D Zeuschner, C Faber, H Schillers, S Hermann, J Wiseman, JM Vaquerizas, ME Pitulescu, RH Adams Endothelial EphB4 maintains vascular integrity and transport function in adult heart Elife, 2019-11-29;8(0):. 11/29/2019 [PMID: 31782728]
• Joana R Carvalho, Isabela C Fortunato, Catarina G Fonseca, Anna Pezzarossa, Pedro Barbacena, Maria A Dominguez-Cejudo et al. Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration eLife 6/27/2019 [PMID: 31246175]
• Alexandra Brahmer, Elmo Neuberger, Leona Esch-Heisser, Nils Haller, Malene Moeller Jorgensen, Rikke Baek et al. Platelets, endothelial cells and leukocytes contribute to the exercise-triggered release of extracellular vesicles into the circulation Journal of Extracellular Vesicles 12/1/2019 [PMID: 31191831]
• Jinxue Ruan, Hiroyuki Hirai, Dongshan Yang, Linyuan Ma, Xia Hou, Hong Jiang et al. Efficient Gene Editing at Major CFTR Mutation Loci Molecular Therapy - Nucleic Acids 6/7/2019 [PMID: 30852378]
• Gaurav Kaushik, Daniel A. Gil, Elizabeth Torr, Elizabeth S. Berge, Cheryl Soref, Peyton Uhl et al. Quantitative Label‐Free Imaging of 3D Vascular Networks Self‐Assembled in Synthetic Hydrogels Advanced Healthcare Materials 2019-01-01 [PMID: 30565891] (Immunocytochemistry, Human)
• Gaurav Kaushik, Daniel A. Gil, Elizabeth Torr, Elizabeth S. Berge, Cheryl Soref, Peyton Uhl et al. Quantitative Label‐Free Imaging of 3D Vascular Networks Self‐Assembled in Synthetic Hydrogels Advanced Healthcare Materials 1/1/2019 [PMID: 30565891]
• M Riddell, A Nakayama, T Hikita, F Mirzapours, T Kawamura, A Pasha, M Li, M Masuzawa, M Looso, T Steinbache, K Ebnet, M Potente, T Hirose, S Ohno, I Fleming, S Gattenlöhn, PP Aung, T Phung, O Yamasaki, T Yanagi, H Umemura, M Nakayama aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability Nat Commun, 2018-12-17;9(1):5357. 2018-12-17 [PMID: 30559384] (IHC, Human)
• K Nonomura, V Lukacs, DT Sweet, LM Goddard, A Kanie, T Whitwam, SS Ranade, T Fujimori, ML Kahn, A Patapoutia Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation Proc. Natl. Acad. Sci. U.S.A., 2018-11-27;0(0):. 2018-11-27 [PMID: 30482854] (IHC-Fr, Mouse)
• Gorman DE, Wu T, Gilpin SE, Ott HC. A Fully Automated High-Throughput Bioreactor System for Lung Regeneration. Tissue Eng Part C Methods. 10/26/2018 [PMID: 30362896]
• Takao Hikita, Fatemeh Mirzapourshafiyi, Pedro Barbacena, Meghan Riddell, Ayesha Pasha, Mengnan Li et al. PAR ‐3 controls endothelial planar polarity and vascular inflammation under laminar flow EMBO reports 9/1/2018 [PMID: 30018153]
• Xuan Zhai, Yingliang Li, Ping Liang, Lusheng Li, Yudong Zhou, Weidan Zhang et al. PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas Oncology Letters 11/21/2017 [PMID: 29434887]
• Xuan Zhai, Yingliang Li, Ping Liang, Lusheng Li, Yudong Zhou, Weidan Zhang et al. PI3K/AKT/Afadin signaling pathway contributes to pathological vascularization in glioblastomas Oncology Letters 2017-11-21 [PMID: 29434887] (Immunocytochemistry, Human)
• Thomas J. Cunningham, Michael S. Yu, Wesley L. McKeithan, Sean Spiering, Florent Carrette, Chun-Teng Huang et al. Id genes are essential for early heart formation Genes & Development 7/1/2017 [PMID: 28794185]
• Nikoli? MZ, Caritg O, Jeng Q et al. Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids Elife 6/30/2017 [PMID: 28665271]
• J Xu, J Liang, YM Meng, J Yan, XJ Yu, CQ Liu, L Xu, SM Zhuang, L Zheng Vascular CXCR4 expression promotes vessel sprouting and sensitivity to sorafenib treatment in hepatocellular carcinoma Clin. Cancer Res, 2017-02-21;0(0):. 2017-02-21 [PMID: 28223275] (ICC, Human)
• Gomi K, Tang Y, Arbelaez V et al. Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling. Stem Cell Rev. 4/1/2017 [PMID: 28050756]
• Yijie Geng, Bradley Feng A small molecule-based strategy for endothelial differentiation and three-dimensional morphogenesis from human embryonic stem cells Heliyon 7/25/2016 [PMID: 27512727]
• DeepCAGE transcriptomics identify HOXD10 as transcription factor regulating lymphatic endothelial responses to VEGF-C J Cell Sci, 2016-05-19;0(0):. 2016-05-19 [PMID: 27199372] (Western Blot, Human)
• Matthew R. Zanotelli, Hamisha Ardalani, Jue Zhang, Zhonggang Hou, Eric H. Nguyen, Scott Swanson et al. Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels Acta Biomaterialia 4/15/2016 [PMID: 26945632]
• Wang J, Tao J, Chen D, Cai J, Irani K, Wang Q, Yuan H, Chen A MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol, 2013-10-31;34(0):99. 2013-10-31 [PMID: 24177325] (Flow Cytometry, Mouse)
• Niwa A, Heike T, Umeda K A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors. PLoS ONE, 2011-07-27;6(7):e22261. 2011-07-27 [PMID: 21818303] (ICC, Human)
• Kelly MA, Hirschi KK Signaling hierarchy regulating human endothelial cell development. Arterioscler. Thromb. Vasc. Biol., 2009-02-12;29(5):718-24. 2009-02-12 [PMID: 19213939] (ICC, Human)

Bioinformatics

• Gene Symbol: CDH5
• Uniprot:
  • P33151()