WB, Simple Western, IHCHost:
WB, ICC/IF, IHC, IHC-Fr, IPHost:
WB, Flow, CyTOF-ready, ICC/IFHost:
Applications: ELISA, Ctrl
VE-cadherin (cadherin-5) is an endothelial specific adhesion molecule that is essential for the maintenance of endothelial barrier function and angiogenesis. VE-cadherin is linked to the actin cytoskeleton through a number of adaptor proteins including a-, â-, and ã-catenin. Cytoskeletal dynamics and phosphorylation regulate VE-cadherin mediated cell-cell adhesion. The cytosolic C-terminal Src kinase (Csk) binds via its SH2 domain to the phosphorylated tyrosine 658 site of VE-cadherin. This interaction regulates density dependent cell proliferation. Phosphorylation of tyrosine 658 has also been shown to lead to the uncoupling of p120-catenin from the cytoplasmic tail of VE-cadherin. This phosphorylation event is sufficient to maintain cells in a mesenchymal state during the cell invasion phase of angiogenesis.
|Product By Gene ID
- Vascular endothelial cadherin
- endothelial-specific cadherin
- CD144 antigen
- cadherin 5, type 2, VE-cadherin (vascular epithelium)
- 7B4 antigen
- cadherin 5, type 2 (vascular endothelium)
Bioinformatics Tool for VE-Cadherin
Discover related pathways, diseases and genes to VE-Cadherin. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.