VE-Cadherin Antibody (BV13) Summary
The immunogen for this antibody was CD144.
Endothelial Cell Marker
Protein A or G purified
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Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Aqueous buffer, may contain carrier protein/stabilizer (proprietary).
0.09% Sodium Azide
Protein A or G purified
- Western Blot 1:100-1:2000
- Flow Cytometry < = 1 ug/10^6 cells in 100 ul
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Frozen 1:10-1:500
- Immunoprecipitation 1:10-1:500
Intravenous injection of BV13 has been shown to induce a concentration- and timedependent increase in vascular permeability in the heart and lungs.
Alternate Names for VE-Cadherin Antibody (BV13)
- 7B4 antigen
- cadherin 5, type 2 (vascular endothelium)
- cadherin 5, type 2, VE-cadherin (vascular epithelium)
- CD144 antigen
- endothelial-specific cadherin
- Vascular endothelial cadherin
The BV13 monoclonal antibody reacts with mouse VE-Cadherin (CD144). VE-Cadherin is a 120 kDa member of the type II Cadherin family, characterized by the presence of 5 extracellular cadherin domains (ECD), and anchored to the actin cytoskeleton through their cytoplasmic tail. VE-Cadherin mediates homophilic adhesion between neighbouring endothelial cells and is localized within specialized structures at cell-cell contacts, called adherens junctions. VE-Cadherin is expressed constitutively throughout the entire vasculature, and is required for numerous endothelial cell functions including migration, survival, contact-dependent growth inhibition and endothelial cell assembly into tubular structures. Furthermore, it is thought that VE-Cadherin+CD45- cells from the yolk sac or aorta-gonad-mesonephros (AGM) have the potential to give rise to hematopoietic cells.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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Other Available Formats
Additional VE-Cadherin Antibody (BV13) Products
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Bioinformatics Tool for VE-Cadherin Antibody (NBP1-43348)
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