VCAM-1/CD106 Antibody (1.G11B1) [PE]

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Flow Cytometry: VCAM-1/CD106 Antibody (1.G11B1) [PE] [NBP1-28407] - Analysis of TNF alpha stimulated endothelial cell line HUV-EC-C.

Product Details

Summary
Reactivity Hu, PoSpecies Glossary
Applications WB, ELISA, Flow, IHC, IHC-Fr
Clone
1.G11B1
Clonality
Monoclonal
Host
Mouse
Conjugate
PE

Order Details

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Catalog# & Conjugate Size Price

VCAM-1/CD106 Antibody (1.G11B1) [PE] Summary

Immunogen
The immunogen is a peptide made to the amino acid region VCAM1
Specificity
Human CD106/VCAM-1
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
VCAM1
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Flow Cytometry 10 uL/10^6 cells
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS and a stabilizing agent
Preservative
Sodium Azide
Purity
Protein A or G purified

Notes

Protect conjugated forms from light.

Alternate Names for VCAM-1/CD106 Antibody (1.G11B1) [PE]

  • CD106 antigen
  • CD106
  • DKFZp779G2333
  • INCAM-100
  • L1CAM
  • MGC99561
  • vascular cell adhesion molecule 1
  • vascular cell adhesion protein 1
  • V-CAM 1
  • VCAM1
  • VCAM-1

Background

CD106, also known as INCAM-1, is a 100-110 kDa vascular adhesion cell adhesion molecule-1 (VCAM-1) that is member of the immunoglobulin superfamily. CD106 is expressed predominantly on cytokine activated vascular endothelium but has also been identified on interfollicular dendritic cells, some macrophages and bone marrow stromal cells. Endothelial CD106 binds the integrins alpha4beta1 (CD49d/CD29, VLA-4) and alpha4beta7 and contributes to extravasation of lymphocytes, monocytes, basophils and eosinophils (but not neutrophils) from blood vessels, particularly at sites of inflammation. Unlike the beta2 integrins, the CD106-VLA-4 interaction can mediate both the initial tethering and rolling of lymphocytes on endothelium as well as their subsequent arrest and firm adhesion. CD106 expressed on non-vascular tissues has been implicated in the interaction of hematopoietic progenitors with bone marrow stromal cells, B cell binding to follicular dendritic cells, costimulation of T cells, and embryonic development. The monoclonal antibody 1.G11B1 inhibits in vitro binding of lymphocytes and monocytes to VCAM-1 on stimulated endothelium. (1-4)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NBP1-28406
FITC Labeled NBP1-28405

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Bioinformatics

Gene Symbol VCAM1
Entrez