Tyrosinase Antibody (2A2-F4)

Images

 
Western Blot: Tyrosinase Antibody (2A2-F4) [H00007299-M01] - TYR monoclonal antibody (M01), clone 2A2-F4 Analysis of TYR expression in A-431.
Immunocytochemistry/ Immunofluorescence: Tyrosinase Antibody (2A2-F4) [H00007299-M01] - Analysis of monoclonal antibody to TYR on Jurkat cell. Antibody concentration 10 ug/ml.
Immunohistochemistry-Paraffin: Tyrosinase Antibody (2A2-F4) [H00007299-M01] - Analysis of monoclonal antibody to TYR on formalin-fixed paraffin-embedded human liver tissue. Antibody concentration 3 ug/ml.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC-P
Clone
2A2-F4
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Tyrosinase Antibody (2A2-F4) Summary

Immunogen
TYR (AAH27179.1, 1 a.a. - 377 a.a.) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQPLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEEMGFLHVGWAGLKLLTSRDPPPWPPKMLGLQA
Localization
Melanosomal membrane; single pass type I membrane protein.
Specificity
TYR - tyrosinase (oculocutaneous albinism IA)
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TYR
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Paraffin
Application Notes
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IHC-P and ELISA.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
IgG purified

Notes

Quality control test: Antibody Reactive Against Recombinant Protein.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Tyrosinase Antibody (2A2-F4)

  • CMM8
  • EC 1.14.18.1
  • LB24-AB
  • Monophenol monooxygenase
  • OCA1A
  • OCAIA
  • SHEP3
  • SK29-AB
  • Tumor rejection antigen AB
  • tyrosinase (oculocutaneous albinism IA)
  • tyrosinase

Background

Tyrosinase is a copper containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway. It is thought to catalyze the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. A mutant allele of TYR is a common cause of autosomal recessive ocular albinism, also known as tyrosinase negative oculocutaneous albinism. This is an autosomal recessive disorder characterized by absence of pigment in hair, skin and eyes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol TYR
Entrez
OMIM
Uniprot