Tyrosinase Products

Antibodies
Tyrosinase Antibody (2A2-F4)
Tyrosinase Antibody (2A2-F4)
H00007299-M01
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Tyrosinase Antibody (T311)
Tyrosinase Antibody (T311)
NBP1-40201
Species: Hu, Ca, Fe
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Antibody Pairs
Tyrosinase Antibody Pair
Tyrosinase Antibody Pair
H00007299-PW1
Species: Hu
Applications: WB, IP
Lysates
Tyrosinase Overexpression Lys ...
Tyrosinase Overexpression Lysate (...
H00007299-T01
Species: Hu
Applications: WB
Tyrosinase Overexpression Lys ...
Tyrosinase Overexpression Lysate (...
NBP2-10667
Applications: WB
Proteins
Tyrosinase Recombinant Protei ...
Tyrosinase Recombinant Protein
H00007299-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Tyrosinase RNAi
Tyrosinase RNAi
H00007299-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Tyrosinase is a rate-limiting enzyme in the melanin biosynthetic pathway and a complete defect of the enzyme activity caused by homozygous mutations of the tyrosinase gene is well known to result in tyrosinase-negative oculocutaneous albinism (OCA1A) patients who never develop any melanin pigment in the skin, hair and eyes throughout life (1). Tyrosinase catalyzes the first two steps of melanin biosynthesis. Mutations of the TYR gene have been identified in a large number of patients, most of Caucasian ethnic origin, with various forms of type I OCA (2). Type I OCA results from mutations of the gene encoding tyrosinase, the enzyme that catalyzes the first 2 steps of melanin pigment biosynthesis. In type IA (tyrosinase-negative) OCA tyrosinase enzymatic activity is completely absent, and in type IB ("yellow") OCA tyrosinase activity is greatly reduced. More than 80% of the known missense substitutions associated with type I OCA cluster within 2 relatively small regions of the tyrosinase polypeptide, suggesting that these may correspond to functionally important sites within the enzyme (3).

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 7299
Alternate Names
  • SK29-AB
  • tyrosinase
  • LB24-AB
  • OCA1A
  • Tumor rejection antigen AB
  • SHEP3
  • Monophenol monooxygenase
  • CMM8
  • OCAIA
  • EC 1.14.18.1
  • tyrosinase (oculocutaneous albinism IA)

Research Areas for Tyrosinase

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism

Bioinformatics Tool for Tyrosinase

Discover related pathways, diseases and genes to Tyrosinase. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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