TREM2 Antibody [Unconjugated]

Western blot shows lysates of THP-1 human acute monocytic leukemia cell line. PVDF membrane was probed with 0.2 µg/mL of Goat Anti-Human TREM2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1828) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for TREM2 at approximately 28 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

TREM2 was detected in immersion fixed immature human dendritic cells using Goat Anti-Human TREM2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1828) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Recombinant Human TREM2 protein was serially diluted 2-fold and captured by Mouse Anti-Human TREM2 Monoclonal Antibody(Catalog # MAB18281) coated on a Clear Polystyrene Microplate (Catalog # DY990). Goat Anti-Human TREM2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1828) was biotinylated and incubated with the protein captured on the plate. Detection of the standard curve was achieved by incubating Streptavidin-HRP (Catalog # DY998) followed by Substrate Solution (Catalog # DY999) and stopping the enzymatic reaction with Stop Solution (Catalog # DY994).

TREM2 is shed at a single cleavage site in the ectodomain between histidine 157 and serine 158Regulated intramembrane proteolysis of TREM2. ADAM10 initiates proteolytic processing of TREM2 by liberating its ectodomain (sTREM2). Subsequent processing of the membrane retained C‐terminal fragment (CTF) by gamma ‐secretase within the transmembrane domain (TM) releases the intracellular domain (ICD) into the cytosol. A short p3‐like peptide (Haass et al, 1993) may be secreted.Outline of strategy I for mass spectrometric (MS) determination of the N‐terminal end of the TREM2 CTF enriched upon gamma ‐secretase inhibition using DAPT.Western blot analysis of TREM2 stably expressed in HEK293 Flp‐In cells upon gamma ‐secretase inhibition using DAPT. Application of DAPT leads to a robust accumulation of the TREM2 CTF under constitutive conditions as well as upon phorbol 12‐myristate 13‐acetate (PMA) mediated stimulation of TREM2 ectodomain shedding. The TREM2 9D11 antibody raised against the TREM2 C‐terminus was used to detect TREM2, and calnexin levels were analyzed as a loading control. Here, as in all other Western blots in Figs 1 and 2, the two lanes represent samples from two separate wells seeded at the same time.MALDI‐TOF MS determination of the ectodomain cleavage site by immunoprecipitation of TREM2 CTF. The peak at 8,841.48 Da corresponds to a single cleavage site between histidine 157 and serine 158. Very minor additional peaks may represent cellular degradation products, as the N‐terminal counterpart cannot be observed (see Fig 1I).Stimulation of ectodomain shedding by PMA leads to strong increases in sTREM2 (anti‐HA, upper panel) and sAPP alpha (2D8, lower panel). DMSO served as a vehicle control. EV, empty vector control.MALDI‐TOF MS determination of the ectodomain cleavage site upon ADAM17 stimulation using PMA. TREM2 CTFs were enriched by gamma ‐secretase inhibition using DAPT (Fig 1C). The peak at 8,837.09 Da corresponds to a single cleavage site between histidine 157 and serine 158.Outline of strategy II for MS determination of the C‐terminal end of sTREM2 generated by ectodomain shedding.Western blot analysis of full‐length TREM2‐TEVFlag (middle panel) and ectodomain shedding (upper panel) upon transient transfection of HEK293 Flp‐In cells. EV, empty vector control.MALDI‐TOF MS determination of the ectodomain cleavage site following the strategy outlined in Fig 1G. The peak at a mass of 3,947.78 Da corresponds to cleavage C‐terminal of histidine 157 and is absent in cells transfected with an empty expression vector.TREM2 is shed predominantly C‐terminal to histidine 157 as observed in two different cell types as well as under constitutive and PMA‐stimulated conditions.Western blot analysis of full‐length TREM2‐TEVFlag (middle panel) and ectodomain shedding (upper panel) upon transient transfection of THP‐1 monocytes.MALDI‐TOF MS determination of the ectodomain cleavage site in THP‐1 monocytes following the strategy outlined in Fig 1G. The peak at a mass of 3,943.80 Da corresponds to cleavage C‐terminal of histidine 157 and is absent in cells transfected with an empty expression vector.Source data are available online for this figure. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/28855300), licensed under a CC-BY license. Not internally tested by R&D Systems.

Product Discontinued

TREM2 Antibody [Unconjugated] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human TREM2
  His19-Ser174
  Accession # Q9NZC2
• Specificity: Detects human TREM2 in direct ELISAs and Western blots. In direct ELISAs, less than 50% cross-reactivity with recombinant mouse TREM2b is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: TREM2
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • ELISA
  • Flow Cytometry 2.5 ug/10^6 cells
  • Immunocytochemistry 5-15 ug/mL
  • Western Blot 0.2 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TREM2 Antibody [Unconjugated]

• PLOSL2
• TREM2
• TREM-2
• Trem2a
• Trem2b
• Trem2c
• TREM-2triggering receptor expressed on myeloid cells 2a
• Triggering receptor expressed on monocytes 2
• triggering receptor expressed on myeloid cells 2

Background

TREM2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa molecular weight type I transmembrane member of the TREM family and Ig superfamily . Mature human TREM2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. Within the ECD, human TREM2 shares 73% and 74% aa sequence identity with mouse and rat TREM2, respectively. Two closely related transcripts were reported in mouse and designated TREM2a and TREM2b. Soluble forms of the TREM2 ECD are generated by alternative splicing or proteolytic cleavage, and the cytoplasmic domain can be liberated by gamma-Secretase mediated intramembrane cleavage. It is a pattern recognition receptor that binds anionic ligands. A positively charged lysine within the transmembrane segment allows association with the signal adapter protein, DAP12 to deliver an activating signal that plays a role in both innate and adaptive immune responses, including inhibition of macrophage activation. TREM2 is expressed on macrophages, immature myeloid dendritic cells, osteoclasts, microglia, and adipocytes. It promotes the differentiation and function of osteoclasts, the production of inflammatory cytokines by adipocytes, insulin resistance, and the phagocytic clearance of bacteria. In the CNS, TREM2 binds to ApoE, ApoA1, and ApoB and mediates the clearance of apoptotic neurons, amyloid plaques, and cell debris following demyelination. TREM2 also interacts with and modifies signaling through Plexin A1 on dendritic cells and osteoclasts. Mutations in TREM2 or DAP12 are associated with the development of Alzheimer's disease and Nasu-Hakola disease (NHD/PLOSL) which is characterized by presenile dementia and bone cysts. Soluble TREM2 is elevated in cerebrospinal fluid of patients with active multiple sclerosis (MS), and TREM2 blockade exacerbates disease symptoms in the experimental EAE model of MS.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TREM2 Antibody (AF1828)(31)

Publications using AF1828

• Wang, L;Nykänen, NP;Western, D;Gorijala, P;Timsina, J;Li, F;Wang, Z;Ali, M;Yang, C;Liu, M;Brock, W;Marquié, M;Boada, M;Alvarez, I;Aguilar, M;Pastor, P;Ruiz, A;Puerta, R;Orellana, A;Rutledge, J;Oh, H;Greicius, MD;Le Guen, Y;Perrin, RJ;Wyss-Coray, T;Jefferson, A;Hohman, TJ;Graff-Radford, N;Mori, H;Goate, A;Levin, J;Sung, YJ;Cruchaga, C; Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease Molecular neurodegeneration 2024-01-03 [PMID: 38172904] (Western Blot, Human)
• Dolan, MJ;Therrien, M;Jereb, S;Kamath, T;Gazestani, V;Atkeson, T;Marsh, SE;Goeva, A;Lojek, NM;Murphy, S;White, CM;Joung, J;Liu, B;Limone, F;Eggan, K;Hacohen, N;Bernstein, BE;Glass, CK;Leinonen, V;Blurton-Jones, M;Zhang, F;Epstein, CB;Macosko, EZ;Stevens, B; Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro Nature immunology 2023-08-01 [PMID: 37500887] (ICC, Human)
• B van Lenger, L Zhan, D Xia, D Chan, D Joy, JI Park, D Tatarakis, M Calvert, S Hummel, S Lianoglou, ME Pizzo, R Prorok, E Thomsen, LM Bartos, P Beumers, A Capell, SS Davis, L de Weerd, JC Dugas, J Duque, T Earr, K Gadkar, T Giese, A Gill, J Gnörich, C Ha, M Kannuswamy, DJ Kim, ST Kunte, LH Kunze, D Lac, K Lechtenber, AW Leung, CC Liang, I Lopez, P McQuade, A Modi, VO Torres, HN Nguyen, I Pesämaa, N Propson, M Reich, Y Robles-Col, K Schlepckow, L Slemann, H Solanoy, JH Suh, RG Thorne, C Vieira, K Wind-Mark, K Xiong, YJY Zuchero, D Diaz, MS Dennis, F Huang, K Scearce-Le, RJ Watts, C Haass, JW Lewcock, G Di Paolo, M Brendel, PE Sanchez, KM Monroe A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models Nature Neuroscience, 2023-01-12;0(0):. 2023-01-12 [PMID: 36635496] (Immunoprecipitation, Western Blot, Human)
• CB Pantazis, A Yang, E Lara, JA McDonough, C Blauwendra, L Peng, H Oguro, J Kanaujiya, J Zou, D Sebesta, G Pratt, E Cross, J Blockwick, P Buxton, L Kinner-Bib, C Medura, C Tompkins, S Hughes, M Santiana, F Faghri, MA Nalls, D Vitale, S Ballard, YA Qi, DM Ramos, KM Anderson, J Stadler, P Narayan, J Papademetr, L Reilly, MP Nelson, S Aggarwal, LU Rosen, P Kirwan, V Pisupati, SL Coon, SW Scholz, T Priebe, M Öttl, J Dong, M Meijer, LJM Janssen, VS Lourenco, R van der Ka, D Crusius, D Paquet, AC Raulin, G Bu, A Held, BJ Wainger, RMC Gabriele, JM Casey, S Wray, D Abu-Bonsra, CL Parish, MS Beccari, DW Cleveland, E Li, IVL Rose, M Kampmann, C Calatayud, P Verstreken, L Heinrich, MY Chen, B Schüle, D Dou, ELF Holzbaur, MC Zanellati, R Basundra, M Deshmukh, S Cohen, R Khanna, M Raman, ZS Nevin, M Matia, J Van Lent, V Timmerman, BR Conklin, K Johnson Ch, K Zhang, S Funes, DA Bosco, L Erlebach, M Welzer, D Kronenberg, G Lyu, E Arenas, E Coccia, L Sarrafha, T Ahfeldt, JC Marioni, WC Skarnes, MR Cookson, ME Ward, FT Merkle A reference human induced pluripotent stem cell line for large-scale collaborative studies Cell Stem Cell, 2022-12-01;29(12):1685-1702.e22. 2022-12-01 [PMID: 36459969] (ICC, Human)
• Carmela Gallo, Emiliano Manzo, Giusi Barra, Laura Fioretto, Marcello Ziaco, Genoveffa Nuzzo et al. Sulfavant A as the first synthetic TREM2 ligand discloses a homeostatic response of dendritic cells after receptor engagement Cellular and Molecular Life Sciences 2022-07-01 [PMID: 35723745] (Neutralization, Human)
• S Kiani Shab, S Morabito, EP Danhash, A McQuade, JR Sanchez, E Miyoshi, JP Chadarevia, C Claes, MA Coburn, J Hasselmann, J Hidalgo, KN Tran, AC Martini, W Chang Roth, J Pascual, E Head, DA Hume, C Pridans, H Davtyan, V Swarup, M Blurton-Jo Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice Cell Reports, 2022-06-14;39(11):110961. 2022-06-14 [PMID: 35705056] (Western Blot, Mouse)
• J Obst, HL Hall-Rober, TB Smith, M Kreuzer, L Magno, E Di Daniel, JB Davis, E Mead PLCgamma2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages Scientific Reports, 2021-10-06;11(1):19842. 2021-10-06 [PMID: 34615897] (Functional Assay, Human)
• R Bassil, K Shields, K Granger, I Zein, S Ng, B Chih Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia Nature Communications, 2021-09-01;12(1):5220. 2021-09-01 [PMID: 34471104] (ICC, Human)
• J Wi beta feld, M Mathews, O Mossad, P Picardi, A Cinti, L Redaelli, L Pradier, O Brüstle, H Neumann Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia Scientific Reports, 2021-06-29;11(1):13462. 2021-06-29 [PMID: 34188106] (Stimulation, Human)
• J Schapansky, YY Grinberg, DM Osiecki, EA Freeman, SG Walker, E Karran, SM Gopalakris, RV Talanian MEK1/2 activity modulates TREM2 cell surface recruitment The Journal of Biological Chemistry, 2020-12-25;296(0):100218. 2020-12-25 [PMID: 33839686] (ICC, Human)
• H Hall-Rober, D Agarwal, J Obst, TB Smith, J Monzón-San, E Di Daniel, C Webber, WS James, E Mead, JB Davis, SA Cowley TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages Alzheimers Res Ther, 2020-11-16;12(1):151. 2020-11-16 [PMID: 33198789] (Bioassay, ICC, Western Blot, Human)
• A McQuade, YJ Kang, J Hasselmann, A Jairaman, A Sotelo, M Coburn, SK Shabestari, JP Chadarevia, G Fote, CH Tu, E Danhash, J Silva, E Martinez, C Cotman, GA Prieto, LM Thompson, JS Steffan, I Smith, H Davtyan, M Cahalan, H Cho, M Blurton-Jo Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease Nat Commun, 2020-10-23;11(1):5370. 2020-10-23 [PMID: 33097708] (Functional Assay, Western Blot, Human)
• AB Knapskog, K Henjum, AV Idland, RS Eldholm, K Persson, I Saltvedt, LO Watne, K Engedal, LNG Nilsson Cerebrospinal fluid sTREM2 in Alzheimer's disease: comparisons between clinical presentation and AT classification Sci Rep, 2020-09-28;10(1):15886. 2020-09-28 [PMID: 32985583] (ELISA Capture, Human)
• BJ Andreone, L Przybyla, C Llapashtic, A Rana, SS Davis, B van Lenger, K Lin, J Shi, Y Mei, G Astarita, G Di Paolo, T Sandmann, KM Monroe, JW Lewcock Alzheimer's-associated PLCgamma2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia Nat. Neurosci., 2020-06-08;0(0):. 2020-06-08 [PMID: 32514138] (ICC, Human)
• A Grubman, TH Vandekolk, J Schröder, G Sun, J Hatwell-Hu, J Chan, M Oksanen, S Lehtonen, C Hunt, JE Koistinaho, SK Nilsson, JM Haynes, CW Pouton, JM Polo A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture Stem Cell Reports, 2020-05-21;14(6):1018-1032. 2020-05-21 [PMID: 32442534] (Flow Cytometry, Human)
• K Schlepckow, KM Monroe, G Kleinberge, L Cantuti-Ca, S Parhizkar, D Xia, M Willem, G Werner, N Pettkus, B Brunner, A Sülzen, B Nuscher, H Hampel, X Xiang, R Feederle, S Tahirovic, JI Park, R Prorok, C Mahon, CC Liang, J Shi, DJ Kim, H Sabelström, F Huang, G Di Paolo, M Simons, JW Lewcock, C Haass Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region EMBO Mol Med, 2020-03-10;0(0):e11227. 2020-03-10 [PMID: 32154671] (Western Blot, Human)
• L Zhong, Y Xu, R Zhuo, T Wang, K Wang, R Huang, D Wang, Y Gao, Y Zhu, X Sheng, K Chen, N Wang, L Zhu, D Can, Y Marten, M Shinohara, CC Liu, D Du, H Sun, L Wen, H Xu, G Bu, XF Chen Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model Nat Commun, 2019-03-25;10(1):1365. 2019-03-25 [PMID: 30911003] (IHC, Western Blot, Mouse)
• K Nordengen, BE Kirsebom, K Henjum, P Selnes, B Gísladótti, M Wettergree, SB Torsetnes, GR Grøntvedt, KK Waterloo, D Aarsland, LNG Nilsson, T Fladby Glial activation and inflammation along the Alzheimer's disease continuum J Neuroinflammation, 2019-02-21;16(1):46. 2019-02-21 [PMID: 30791945] (ELISA Development (Capture), Human)
• K Henjum, E Quist-Paul, H Zetterberg, K Blennow, LNG Nilsson, LO Watne CSF sTREM2 in delirium-relation to Alzheimer's disease CSF biomarkers A?42, t-tau and p-tau J Neuroinflammation, 2018-11-03;15(1):304. 2018-11-03 [PMID: 30390679] (ELISA Development (Capture), Human)
• P Garcia-Rei, A Phillips, TM Piers, C Villegas-L, M Butler, A Mallach, C Rodrigues, CE Arber, A Heslegrave, H Zetterberg, H Neumann, S Neame, H Houlden, J Hardy, JM Pocock Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis Cell Rep, 2018-08-28;24(9):2300-2311. 2018-08-28 [PMID: 30157425] (Human)
• M Yanaizu, K Sakai, Y Tosaki, Y Kino, JI Satoh Small nuclear RNA-mediated modulation of splicing reveals a therapeutic strategy for a TREM2 mutation and its post-transcriptional regulation Sci Rep, 2018-05-02;8(1):6937. 2018-05-02 [PMID: 29720600] (Western Blot, Human)
• Y Zhao, X Li, T Huang, LL Jiang, Z Tan, M Zhang, IH Cheng, X Wang, G Bu, YW Zhang, Q Wang, H Xu Intracellular trafficking of TREM2 is regulated by presenilin 1 Exp. Mol. Med., 2017-12-01;49(12):e405. 2017-12-01 [PMID: 29611543] (Western Blot, Human)
• CYD Lee, A Daggett, X Gu, LL Jiang, P Langfelder, X Li, N Wang, Y Zhao, CS Park, Y Cooper, I Ferando, I Mody, G Coppola, H Xu, XW Yang Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models Neuron, 2018-03-07;97(5):1032-1048.e5. 2018-03-07 [PMID: 29518357] (Western Blot, Transgenic Mouse)
• Y Zhao, X Wu, X Li, LL Jiang, X Gui, Y Liu, Y Sun, B Zhu, JC Piña-Cresp, M Zhang, N Zhang, X Chen, G Bu, Z An, TY Huang, H Xu TREM2 Is a Receptor for ?-Amyloid that Mediates Microglial Function Neuron, 2018-03-07;97(5):1023-1031.e7. 2018-03-07 [PMID: 29518356] (Western Blot, Human)
• P Thornton, J Sevalle, MJ Deery, G Fraser, Y Zhou, S Ståhl, EH Franssen, RB Dodd, S Qamar, B Gomez Pere, LS Nicol, S Eketjäll, J Revell, C Jones, A Billinton, PH St George-, I Chessell, DC Crowther TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant EMBO Mol Med, 2017-10-01;0(0):. 2017-10-01 [PMID: 28855301] (Western Blot, Human)
• K Schlepckow, G Kleinberge, A Fukumori, R Feederle, SF Lichtentha, H Steiner, C Haass An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function EMBO Mol Med, 2017-10-01;0(0):. 2017-10-01 [PMID: 28855300] (Western Blot, Human)
• MM Varnum, KA Clayton, A Yoshii-Kit, G Yonemoto, L Koro, S Ikezu, T Ikezu A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells J. Biol. Chem., 2017-05-10;0(0):. 2017-05-10 [PMID: 28490631] (Functional Assay, Human)
• TREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 signaling pathway and osteoclasts activation Sci Rep, 2016-12-09;6(0):38761. 2016-12-09 [PMID: 27934908] (IHC-Fr, Human)
• Ji JD, Park-Min KH, Shen Z, Fajardo RJ, Goldring SR, McHugh KP, Ivashkiv LB Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors. J. Immunol., 2009-11-04;183(11):7223-33. 2009-11-04 [PMID: 19890054] (Western Blot, Human)
• Park-Min KH, Ji JD, Antoniv T, Reid AC, Silver RB, Humphrey MB, Nakamura M, Ivashkiv LB IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression. J. Immunol., 2009-07-22;183(4):2444-55. 2009-07-22 [PMID: 19625651] (Western Blot, Human)
• Quan DN, Cooper MD, Potter JL, Roberts MH, Cheng H, Jarvis GA TREM-2 binds to lipooligosaccharides of Neisseria gonorrhoeae and is expressed on reproductive tract epithelial cells. Mucosal Immunol, 2008-03-05;1(3):229-38. 2008-03-05 [PMID: 19079182] (IHC, Human)

Bioinformatics

• Gene Symbol: TREM2
• Uniprot:
  • Q9NZC2()