TREM1 Antibody (193015) [Unconjugated]

Images

 
Human peripheral blood granulocytes were stained with Mouse Anti-Human TREM‑1 Monoclonal Antibody (Catalog # MAB1278, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-ready, Func
Clone
193015
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

TREM1 Antibody (193015) [Unconjugated] Summary

Additional Information
Clone 193015 was used by HLDA to establish CD designation
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human TREM-1
Ala21-Asn205
Accession # Q9NP99
Specificity
Detects human TREM-1 in direct ELISAs.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TREM1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25 ug/10^6 cells
  • Agonist Activity
  • CyTOF-ready
Publications
Read Publications using
MAB1278 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TREM1 Antibody (193015) [Unconjugated]

  • CD354 antigen
  • CD354
  • TREM1
  • TREM-1
  • TREM-1Triggering receptor expressed on monocytes 1
  • triggering receptor expressed on myeloid cells 1
  • triggering-receptor TREM1

Background

TREM-1 (Triggering Receptor Expressed on Myeloid cells) is a type I transmembrane protein having a single Ig-like domain. It associates with the adapter protein, DAP12, to deliver an activating signal. Several other TREM family members have been reported that are structurally similar but share less than 30% amino acid identity. TREM-1 is expressed on blood neutrophils and a subset of monocytes, and expression is up-regulated by bacterial LPS. The natural ligand for TREM-1 has not been identified. However, engagement of TREM-1 with an agonist monoclonal antibody leads to expression of IL-8, MCP-1, and TNF-alpha, suggesting that this receptor plays an important role in inflammatory responses. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with
LPS-induced shock. Blockade of TREM-1 with a TREM-1/Fc fusion protein protected mice against LPS-induced shock. Human and mouse TREM-1 share approximately 42% amino acid sequence homology (1-3).

  1. Bouchon, A. (2000) J. Immunol. 164:4991.
  2. Bouchon, A. (2001) Nature 410:1103.
  3. Nathan, C. and A. Ding (2001) Nature Med. 7:530.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TREM1 Antibody (MAB1278)(13)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 8 applications: Activation, Bioassay, ELISA Development, ELISA Development (Capture), Flow Cytometry, Functional Assay, Neutralization, Western Blot.


Filter By Application
Activation
(1)
Bioassay
(1)
ELISA Development
(1)
ELISA Development (Capture)
(1)
Flow Cytometry
(3)
Functional Assay
(4)
Neutralization
(1)
Western Blot
(1)
All Applications
Filter By Species
Human
(11)
Mouse
(2)
All Species
Showing Publications 1 - 10 of 13. Show All 13 Publications.
Publications using MAB1278 Applications Species
GR Campbell, RK To, SA Spector TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function MBio, 2019;10(6):. 2019 [PMID: 31719184] (Functional Assay, Human) Functional Assay Human
M Canavan, AM Walsh, V Bhargava, SM Wade, T McGarry, V Marzaioli, B Moran, M Biniecka, H Convery, S Wade, C Orr, R Mullan, JM Fletcher, S Nagpal, DJ Veale, U Fearon Enriched Cd141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis JCI Insight, 2018;3(23):. 2018 [PMID: 30518680] (Functional Assay, Human) Functional Assay Human
L Jolly, K Carrasco, M Derive, J Lemarié, A Boufenzer, S Gibot Targeted endothelial gene deletion of Triggering Receptor Expressed on Myeloid cells-1 protects mice during septic shock Cardiovasc. Res., 2018;0(0):. 2018 [PMID: 29361046] (Activation, Mouse) Activation Mouse
AA Aldasoro A, S Dadé, M Stathopoul, M Derive, N Coumba Ndi, T Xie, C Masson, S Gibot, S Visvikis-S TREM-1 SNP rs2234246 regulates TREM-1 protein and mRNA levels and is associated with plasma levels of L-selectin PLoS ONE, 2017;12(8):e0182226. 2017 [PMID: 28771614] (ELISA Development (Capture), Human) ELISA Development (Capture) Human
A Tammaro, M Derive, S Gibot, JC Leemans, S Florquin, MC Dessing TREM-1 and its potential ligands in non-infectious diseases: from biology to clinical perspectives Pharmacol. Ther, 2017;0(0):. 2017 [PMID: 28245991] (Functional Assay, Mouse) Functional Assay Mouse
TREM-1low is a novel characteristic for tumor-associated macrophages in lung cancer Oncotarget, 2016;7(26):40508-40517. 2016 [PMID: 27244892] (Flow Cytometry, Human) Flow Cytometry Human
Read C, Kuijper J, Hjorth S, Heipel M, Tang X, Fleetwood A, Dantzler J, Grell S, Kastrup J, Wang C, Brandt C, Hansen A, Wagtmann N, Xu W, Stennicke V Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1. J Immunol, 2015;194(4):1417-21. 2015 [PMID: 25595774] (Flow Cytometry, Human) Flow Cytometry Human
Bosco MC, Pierobon D, Blengio F, Raggi F, Vanni C, Gattorno M, Eva A, Novelli F, Cappello P, Giovarelli M, Varesio L Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo. Blood, 2011;117(9):2625-39. 2011 [PMID: 21148811] (Western Blot, Human) Western Blot Human
Ingersoll MA, Spanbroek R, Lottaz C Comparison of gene expression profiles between human and mouse monocyte subsets. Blood, 2010;115(3):e10-9. 2010 [PMID: 19965649] (Flow Cytometry, Human) Flow Cytometry Human
Murakami Y, Akahoshi T, Aoki N, Toyomoto M, Miyasaka N, Kohsaka H Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis. Arthritis Rheum., 2009;60(6):1615-23. 2009 [PMID: 19479878] (Functional Assay, Human) Functional Assay Human
Show All 13 Publications.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB1278U
Alexa Fluor 405 FAB1278V
Alexa Fluor 488 FAB1278G
Alexa Fluor 594 FAB1278T
Alexa Fluor 647 FAB1278R
Alexa Fluor 700 FAB1278N
Alexa Fluor 750 FAB1278S
Allophycocyanin FAB1278A
Phycoerythrin FAB1278P

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Blogs on TREM1.

TREM1: An inflammatory signal protein with a potential role in cancer
TREM1 is pro-inflammatory gene that stimulates neutrophil and monocyte-mediated inflammatory responses. This protein is highly expressed in adult liver, lung and spleen. It is also present in the lymph node, spinal cord and heart tissues. TREM-1 plays...  Read full blog post.

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Bioinformatics

Gene Symbol TREM1
Uniprot