OSCAR Antibody (218311)

• Reactivity: Mu
• Applications: WB
• Clone: 218311
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Unconjugated
• Concentration: LYOPH

OSCAR Antibody (218311) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse OSCAR
  Asp19-Asn228
  Accession # Q8VBT3
• Specificity: Detects mouse OSCAR in direct ELISAs and Western blots. In Western blots, this antibody shows weak cross-reactivity with recombinant human OSCAR.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: OSCAR
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for OSCAR Antibody (218311)

• hOSCAR
• MGC33613
• OSCAR
• osteoclast associated receptor OSCAR-S1
• osteoclast associated receptor OSCAR-S2
• osteoclast associated, immunoglobulin-like receptor
• osteoclast-associated immunoglobulin-like receptor
• Osteoclast-associated receptor
• PIGR3
• PIgR-3
• Poly-Ig receptor 3
• Polymeric immunoglobulin receptor 3

Background

OSCAR is a type I transmembrane protein that is expressed specifically on osteoclast-lineage cells and regulates osteoclast differentiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for OSCAR Antibody (MAB1633)(5)

Publications using MAB1633

• Jeong, C;Lee, CH;Lee, Y;Seo, J;Wang, W;Park, KH;Oh, E;Cho, Y;Park, C;Son, YJ;Yoon Park, JH;Kang, H;Lee, KW; Ulmus macrocarpa Hance trunk bark extracts inhibit RANKL-induced osteoclast differentiation and prevent ovariectomy-induced osteoporosis in mice Journal of ethnopharmacology 2023-10-13 [PMID: 37839769] (Western Blot, Mouse)
• Jeong J W, Ji S Y et al. Fermented Sea Tangle (Laminaria japonica Aresch) Suppresses RANKL-Induced Osteoclastogenesis by Scavenging ROS in RAW 264.7 Cells. Foods 7/26/2019 [PMID: 31357503]
• J Liu, D Li, L Dang, C Liang, B Guo, C Lu, X He, HY Cheung, B He, B Liu, F Li, J Lu, L Wang, AB Shaikh, F Jiang, C Lu, S Peng, Z Zhang, BT Zhang, X Pan, L Xiao, A Lu, G Zhang Osteoclastic miR-214 targets TRAF3 to contribute to osteolytic bone metastasis of breast cancer Sci Rep, 2017-01-10;7(0):40487. 2017-01-10 [PMID: 28071724] (Binding Assay, Mouse)
• Defang Li, Jin Liu, Baosheng Guo, Chao Liang, Lei Dang, Cheng Lu et al. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation Nature Communications 3/7/2016 [PMID: 26947250]
• Ochi S, Shinohara M, Sato K, Gober HJ, Koga T, Kodama T, Takai T, Miyasaka N, Takayanagi H Pathological role of osteoclast costimulation in arthritis-induced bone loss. Proc. Natl. Acad. Sci. U.S.A., 2007-06-25;104(27):11394-9. 2007-06-25 [PMID: 17592115] (Western Blot, Human)

Bioinformatics

• Gene Symbol: OSCAR
• Uniprot:
  • Q8VBT3()