TRAP220/MED1 Antibody [DyLight 680]

• Reactivity: Hu, Mu, Mu, Pm-Or
• Applications: WB, IHC, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 680

TRAP220/MED1 Antibody [DyLight 680] Summary

• Description: This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
• Immunogen: The immunogen recognized by this antibody maps to a region between residue 1525 and the C-terminus (residue 1581) of human Cofactor Required for Sp1 Transcriptional Activation 1using the numbering given in entry NP_004765.2 (GeneID 5469).
• Predicted Species: Mouse (100%), Orangutan (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MED1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Orangutan (100%).

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for TRAP220/MED1 Antibody [DyLight 680]

• Activator-recruited cofactor 205 kDa component
• ARC205
• CRSP1TRIP2
• CRSP200p53 regulatory protein RB18A
• DRIP230
• DRIP230PPAR-binding protein
• MBD4
• MED1
• mediator complex subunit 1DRIP205
• mediator of RNA polymerase II transcription subunit 1
• PBPPPARGBP
• Peroxisome proliferator-activated receptor-binding protein
• PPAR binding protein
• PPARBP
• PPARBPMGC71488
• PPARG binding protein
• PPARGBP
• RB18ATR-interacting protein 2
• Thyroid hormone receptor-associated protein complex 220 kDa component
• thyroid hormone receptor-associated protein complex component TRAP220
• thyroid receptor interacting protein 2
• Thyroid receptor-interacting protein 2
• TRAP220
• TRAP220TRIP-2
• TRIP2
• vitamin D receptor-interacting protein 230 kD
• Vitamin D receptor-interacting protein complex component DRIP205

Background

MED1, also referred to as Mediator Complex Subunit 1, localizes to the nucleus and is involved in DNA repair. MED1 is able to remove Uracil in Uracil-Guanine mismatched base-pairs. Current research on MED1 is being performed in relation to several diseases and disorders including ovarian cancer, thyroiditis, breast cancer, Parkinson's disease, influenza, alopecia, Williams syndrome, diabetes mellitus, ataxia telangiectasia, thyroid cancer, Alzheimer's disease and rickets. MED1 has also been shown to have interactions with p53, MED15, RARA, KAT2A, and CDK8 in pathways such as fatty acid, triacylglycerol, and ketone body metabolism and the PPAR pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MED1
• Entrez:
  • 5469(Human)
  • 19014(Mouse)
• Uniprot:
  • NP_004765.2(Human)