TRAP220/MED1 Products

Description

TRAP220 works with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53 dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize (referenced from Entrez Gene).

Bioinformatics

Entrez	5469 Human 19014 Mouse
Uniprot	NP_004765.2 Human
Product By Gene ID	5469
Alternate Names	Activator-recruited cofactor 205 kDa component ARC205 CRSP1TRIP2 CRSP200p53 regulatory protein RB18A DRIP230 DRIP230PPAR-binding protein MBD4 MED1 mediator complex subunit 1DRIP205 mediator of RNA polymerase II transcription subunit 1 PBPPPARGBP Peroxisome proliferator-activated receptor-binding protein PPAR binding protein PPARBP PPARBPMGC71488 PPARG binding protein PPARGBP RB18ATR-interacting protein 2 Thyroid hormone receptor-associated protein complex 220 kDa component thyroid hormone receptor-associated protein complex component TRAP220 thyroid receptor interacting protein 2 Thyroid receptor-interacting protein 2 TRAP220 TRAP220TRIP-2 TRIP2 vitamin D receptor-interacting protein 230 kD Vitamin D receptor-interacting protein complex component DRIP205

Research Areas for TRAP220/MED1

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Cancer