Human CXCL7/NAP-2 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human CXCL7/NAP-2 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: PPBP

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CXCL7/NAP-2 DuoSet ELISA, 15 Plate

• Beta-TG
• connective tissue-activating peptide III
• CTAP III
• CTAP3CTAP-III
• CTAPIII
• CXC chemokine ligand 7
• C-X-C motif chemokine 7
• CXCL7
• CXCL7b-TG1
• LA-PF4
• LDGFTC1
• Leukocyte-derived growth factor
• low-affinity platelet factor IV
• Macrophage-derived growth factor
• MDGFTC2
• NAP2
• NAP-2
• NAP-2-L1
• neutrophil-activating peptide 2
• neutrophil-activating peptide-2
• PBPTHBGB
• platelet basic protein
• PPBP
• pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
• SCAR10
• SCYB7beta-thromboglobulin
• small inducible cytokine B7
• small inducible cytokine subfamily B, member 7
• Small-inducible cytokine B7
• TGB
• TGB1B-TG1
• THBGB1
• thrombocidin 1
• thrombocidin 2
• thromboglobulin, beta-1

Background

Neutrophil activating peptide 2 (NAP-2), connective tissue activating protein III (CTAP-III) and beta-thrombogulin (beta-TG), are proteolytically processed carboxy-terminal fragments of platelet basic protein (PBP), which is found in the alpha-granules of human platelets. NAP-2 is a member of the CXC chemokines and is named CXCL7. Similar to other ELR domain containing CXC chemokines, such as IL-8 and the GRO proteins, NAP-2 binds CXCR2 and chemoattracts and activates neutrophils.

Publications for CXCL7/NAP-2 (DY393)(18)

Publications using DY393

• Lengvenyte, A;Cognasse, F;Hamzeh-Cognasse, H;Sénèque, M;Strumila, R;Olié, E;Courtet, P; Baseline circulating biomarkers, their changes, and subsequent suicidal ideation and depression severity at 6 months: A prospective analysis in patients with mood disorders Psychoneuroendocrinology 2024-07-06 [PMID: 39003840] (Human)
• Fyksen, TS;Seljeflot, I;Vanberg, P;Atar, D;Halvorsen, S; Platelet activity, coagulation, and fibrinolysis in long-term users of anabolic-androgenic steroids compared to strength-trained athletes Thrombosis research 2024-04-24 [PMID: 38676967] (Human)
• Friebel, J;Wegner, M;Blöbaum, L;Schencke, PA;Jakobs, K;Puccini, M;Ghanbari, E;Lammel, S;Thevathasan, T;Moos, V;Witkowski, M;Landmesser, U;Rauch-Kröhnert, U; Characterization of Biomarkers of Thrombo-Inflammation in Patients with First-Diagnosed Atrial Fibrillation International journal of molecular sciences 2024-04-08 [PMID: 38612918] (Human)
• Lee, GH;Lee, SY;Chae, JY;Kim, JW;Kim, JH;Jeong, HG; Antarctic Krill Oil from Euphausia superba Ameliorates Carrageenan-Induced Thrombosis in a Mouse Model International journal of molecular sciences 2023-12-13 [PMID: 38139268] (Mouse)
• S Guerrero, E Sánchez-Ti, L Agüí, A González-C, P Yáñez-Sede, JM Pingarrón Development of an Electrochemical CCL5 Chemokine Immunoplatform for Rapid Diagnosis of Multiple Sclerosis Biosensors, 2022-08-07;12(8):. 2022-08-07 [PMID: 36005006] (Human)
• MH Schutte, R Kleemann, NM Nota, CM Wiepjes, JM Snabel, G T'Sjoen, A Thijs, M den Heijer The effect of transdermal gender-affirming hormone therapy on markers of inflammation and hemostasis PLoS ONE, 2022-03-15;17(3):e0261312. 2022-03-15 [PMID: 35290388] (Human)
• L Kloss, C Dollt, K Schledzews, A Krewer, S Melchers, C Manta, C Sticht, C Torre, J Utikal, V Umansky, A Schmieder ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12 Cell Death Dis, 2019-10-07;10(10):760. 2019-10-07 [PMID: 31591378] (Human)
• T Barwari, S Eminaga, U Mayr, R Lu, PC Armstrong, MV Chan, M Sahraei, M Fernández-, T Moreau, J Barallobre, M Lynch, X Yin, C Schulte, F Baig, R Pechlaner, SR Langley, A Zampetaki, P Santer, M Weger, R Plasenzott, M Schosserer, J Grillari, S Kiechl, J Willeit, AM Shah, C Ghevaert, TD Warner, C Fernández-, Y Suárez, M Mayr Inhibition of profibrotic microRNA-21 affects platelets and their releasate JCI Insight, 2018-11-02;3(21):. 2018-11-02 [PMID: 30385722] (Human)
• S Sabrkhany, MJE Kuijpers, SMJ van Kuijk, L Sanders, S Pineda, SWM Olde Damin, AC Dingemans, AW Griffioen, MGA Oude Egbri A combination of platelet features allows detection of early-stage cancer Eur. J. Cancer, 2017-05-17;80(0):5-13. 2017-05-17 [PMID: 28527393] (Human)
• L van Bon, AJ Affandi, J Broen, RB Christmann, RJ Marijnisse, L Stawski, GA Farina, G Stifano, AL Mathes, M Cossu, M York, C Collins, M Wenink, R Huijbens, R Hesselstra, T Saxne, M DiMarzio, D Wuttge, SK Agarwal, JD Reveille, S Assassi, M Mayes, Y Deng, JP Drenth, J de Graaf, M den Heijer, CG Kallenberg, M Bijl, A Loof, WB van den Be, LA Joosten, V Smith, F de Keyser, R Scorza, C Lunardi, PL van Riel, M Vonk, W van Heerde, S Meller, B Homey, L Beretta, M Roest, M Trojanowsk, R Lafyatis, TR Radstake Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis N. Engl. J. Med, 2013-12-18;370(5):433-43. 2013-12-18 [PMID: 24350901] (Human)
• Tavoosidana G, Ronquist G, Darmanis S, Yan J, Carlsson L, Wu D, Conze T, Ek P, Semjonow A, Eltze E, Larsson A, Landegren UD, Kamali-Moghaddam M Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer. Proc. Natl. Acad. Sci. U.S.A., 2011-05-09;108(21):8809-14. 2011-05-09 [PMID: 21555566] (Human)
• Landro L, Ueland T, Otterdal K, Froland SS, Aukrust P Persistently raised plasma levels of platelet-derived inflammatory mediators in HIV-infected patients during highly active anti-retroviral therapy. J. Thromb. Haemost., 2011-05-01;9(5):1075-7. 2011-05-01 [PMID: 21324059] (Human)
• de Mast Q, de Groot PG, van Heerde WL, Roestenberg M, van Velzen JF, Verbruggen B, Roest M, McCall M, Nieman AE, Westendorp J, Syafruddin D, Fijnheer R, van Dongen-Lases EC, Sauerwein RW, van der Ven AJ Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy. Br. J. Haematol., 2010-10-19;151(5):495-503. 2010-10-19 [PMID: 20955404] (Human)
• Pitteri SJ, JeBailey L, Faca VM, Thorpe JD, Silva MA, Ireton RC, Horton MB, Wang H, Pruitt LC, Zhang Q, Cheng KH, Urban N, Hanash SM, Dinulescu DM Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery. PLoS ONE, 2009-11-19;4(11):e7916. 2009-11-19 [PMID: 19936259] (Human)
• Eagan TM, Ueland T, Wagner PD, Hardie JA, Mollnes TE, Damas JK, Aukrust P, Bakke PS Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study. Eur. Respir. J., 2009-07-30;35(3):540-8. 2009-07-30 [PMID: 19643942] (Human)
• Yee J, Sadar MD, Sin DD, Kuzyk M, Xing L, Kondra J, McWilliams A, Man SF, Lam S Connective tissue-activating peptide III: a novel blood biomarker for early lung cancer detection. J. Clin. Oncol., 2009-05-04;27(17):2787-92. 2009-05-04 [PMID: 19414677] (Human)
• Smith C, Damas JK, Otterdal K, ØIe E, Sandberg WJ, Yndestad A, Waehre T, Scholz H, Endresen K, Olofsson PS, Halvorsen B, Gullestad L, Froland SS, Hansson GK, Aukrust P Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation. J. Am. Coll. Cardiol., 2006-09-27;48(8):1591-9. 2006-09-27 [PMID: 17045893] (Human)
• Maheshwari A, Christensen RD, Calhoun DA ELR+ CXC chemokines in human milk. Cytokine, 2003-11-07;24(3):91-102. 2003-11-07 [PMID: 14581003] (Human)

FAQs for CXCL7/NAP-2 (DY393). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: PPBP