TRANCE/TNFSF11/RANK L Antibody

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Western Blot: TRANCE/TNFSF11/RANK L Antibody [NB100-56392] - Analysis of CD254. A. A CD254 recombinant protein fragment. Note: this is not a full-length protein. B. LNCaP lysate using CD254 antibody at 0.5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

TRANCE/TNFSF11/RANK L Antibody Summary

Immunogen
A synthetic peptide corresponding to amino acids 161-177 of mouse CD254 (AQPFAHLTINAASIPSG) was used as immunogen for this antibody.
Specificity
The amino acid sequence used is 88% homologous in human and 94% homologous in rat.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TNFSF11
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.5 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.2% gelatin
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for TRANCE/TNFSF11/RANK L Antibody

  • CD254 antigen
  • CD254
  • ODF
  • OPGL
  • OPGLOPTB2
  • Osteoclast differentiation factor
  • Osteoprotegerin ligand
  • RANK L
  • RANKL
  • RANKLreceptor activator of nuclear factor kappa B ligand
  • Receptor activator of nuclear factor kappa-B ligand
  • sOdf
  • TNF-related activation-induced cytokine
  • TNFSF11
  • TRANCE
  • TRANCEODFhRANKL2
  • tumor necrosis factor (ligand) superfamily, member 11
  • tumor necrosis factor ligand superfamily member 11

Background

TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells (1-2). RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). TRANCE/RANKL is also important in T- and B-cell maturation (3). As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis (4,5). OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis (3). Mouse Trance/RANKL is a 316 amino acid protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics Tool for TRANCE/TNFSF11/RANK L Antibody (NB100-56392)

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Diseases for TRANCE/TNFSF11/RANK L Antibody (NB100-56392)

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PTMs for TRANCE/TNFSF11/RANK L Antibody (NB100-56392)

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Blogs on TRANCE/TNFSF11/RANK L.

The diverse functions of RANKL/TRANCE/TNFSF11
RANKL (also known as TNF-related activation-induced cytokine), or receptor activator of nuclear factor-?B ligand, was first discovered as a key player in the RANKL/RANK/OPG osteoclast formation pathway. Osteoclasts are large multinucleate cells t...  Read full blog post.

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Bioinformatics

Gene Symbol TNFSF11
Entrez
Uniprot