TRANCE/TNFSF11/RANK L Products

Description

TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells (1-2). RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). TRANCE/RANKL is also important in T and B-cell maturation (3). As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis (4). OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis (3).

Bioinformatics

Entrez	117516 Rat 21943 Mouse 8600 Human
Uniprot	ENSP00000351347 Human NM_003701 Human NM_033012 Human NP_003692 Human NP_003692.1 Human NP_143026 Human O14788 Human O35235 Mouse
Product By Gene ID	8600
Alternate Names	CD254 antigen CD254 OPGLOPTB2 Osteoclast differentiation factor Osteoprotegerin ligand RANKLreceptor activator of nuclear factor kappa B ligand Receptor activator of nuclear factor kappa-B ligand sOdf TNF-related activation-induced cytokine TRANCEODFhRANKL2 tumor necrosis factor (ligand) superfamily, member 11 tumor necrosis factor ligand superfamily member 11

Diseases related to TRANCE/TNFSF11/RANK L

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Osteoporosis
Osteopenia
Arthritis
Bone Diseases
Rheumatoid Arthritis
Malignant Neoplasms
Neoplasms
Osteolysis
Inflammation
Bone Neoplasms
Neoplasm Metastasis
Multiple Myeloma
Fracture
Metastatic Malignant Neoplasm To The Bone
Osteoporosis, Postmenopausal
Albers-schonberg Disease
Trance State
Periodontitis
Metabolic Bone Disorder
Malignant Neoplasm Of Breast

Pathways for TRANCE/TNFSF11/RANK L

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Bone Resorption
Osteoclast Differentiation
Bone Remodeling
Pathogenesis
Secretion
Osteoclast Development
Osteoblast Differentiation
Cell Proliferation
Localization
Cell Growth
Immune Response
Cell Differentiation
Cytokine Production
Bone Development
Cell Death
Menopause
Regulation Of Bone Resorption
Transport
Aging
Reverse Transcription

Research Areas for TRANCE/TNFSF11/RANK L

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Cancer

PTMs for TRANCE/TNFSF11/RANK L

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Phosphorylation
Cleavage
Ubiquitination
Acetylation
Methylation
Dephosphorylation
Prenylation
Glycosylation
Oxidation
Geranylgeranylation
Demethylation
Sumoylation
Reduction
Farnesylation

Bioinformatics Tool for TRANCE/TNFSF11/RANK L

Discover related pathways, diseases and genes to TRANCE/TNFSF11/RANK L. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related TRANCE/TNFSF11/RANK L Blog Posts

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The diverse functions of RANKL/TRANCE/TNFSF11 RANKL (also known as TNF-related activation-induced cytokine), or receptor activator of nuclear factor-?B ligand, was first discovered as a key player in the RANKL/RANK/OPG osteoclast formation pathway. Osteoclasts are large multinucleate cells t...    Read more.

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