TRAILR3/TNFRSF10C Antibody - BSA Free

Western Blot: TRAIL R3/TNFRSF10C Antibody [NB100-56445] - Analysis of TRAIL R3/TNFRSF10C 15 ug of mouse spleen cell lysate using this antibody.

• Reactivity: Hu, Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 0.5 mg/ml

TRAILR3/TNFRSF10C Antibody - BSA Free Summary

• Immunogen: This antibody was developed against a synthetic peptide corresponding to amino acids 155-168 ([BLAST]CSSSVSNPRNWLFL[/BLAST]) of mouse DcTrailR1; GenBank no: NP_077252.2.
• Specificity: The amino acid sequence used is 92% homologous in DcTrailR2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TNFRSF10C
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1-3 ug/ml
• Application Notes: In mouse spleen, a 20 kDa band is observed.
• Control:

  Mouse Spleen Whole Tissue Lysate (Adult Whole Normal)

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 31555275).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS containing 0.2% gelatin
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein G purified

Alternate Names for TRAILR3/TNFRSF10C Antibody - BSA Free

• Antagonist decoy receptor for TRAIL/Apo-2L
• CD263 antigen
• CD263
• cytotoxic TRAIL receptor-3
• DcR1
• DCR1MGC149502
• Decoy receptor 1
• Decoy TRAIL receptor without death domain
• LITMGC149501
• Lymphocyte inhibitor of TRAIL
• TNFRSF10C
• TRAIL R3
• TRAIL receptor 3
• TRAIL receptor without an intracellular domain
• TRAILR3
• TRAIL-R3
• TRAILR3TNF-related apoptosis-inducing ligand receptor 3
• TRIDDCR1-TNFR
• tumor necrosis factor receptor superfamily member 10C
• tumor necrosis factor receptor superfamily, member 10c, decoy without anintracellular domain

Background

Mouse DcTRAILR1 and DcTRAILR2 (decoy TRAIL receptors 1 and 2) proteins are receptors for TRAIL according to ligand-receptor binding assays (Schneider et al. 2001). However, overexpression does not cause NF-kB activation or apoptosis, as would be expected of a TRAIL receptor. These observations led researchers to refer to these receptors as decoys. It is thought that cells that express decoy TRAIL receptor decoys at high levels relative to actual TRAIL receptors may use decoys as protection against the cytotoxic action of TRAIL (reviewed in Bouralexis et al. 2005). Additional analysis of these two murine TRAIL decoy receptors should help facilitate the understanding of the complex biology underlying TRAIL ligand/receptor interactions. DcTRAILR1 is an amino acid protein of 176 amino acids (GenBank no: NP-077252.2). DcTRAILR2 is an amino acid protein of 198 amino acids (GenBank no: AAN87807.1).f

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TRAILR3/TNFRSF10C Antibody (NB100-56445)(1)

Publication using NB100-56445

• Tawfik, D;Groth, C;Gundlach, JP;Peipp, M;Kabelitz, D;Becker, T;Oberg, HH;Trauzold, A;Wesch, D; TRAIL-Receptor 4 Modulates gamma δ T Cell-Cytotoxicity Toward Cancer Cells Front Immunol 2019-08-28 [PMID: 31555275] (WB, Human)

Bioinformatics

• Gene Symbol: TNFRSF10C