Growth Hormone Antibody [Unconjugated]


Western blot shows lysates of human, mouse, and rat pituitary gland tissue. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Human Growth Hormone Antigen Affinity-purified Polyclonal Antibody (Catalog # more
Growth Hormone was detected in immersion fixed paraffin-embedded sections of human pituitary using Goat Anti-Human/Mouse/Rat Growth Hormone Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1067) at 10 µg/mL more
Recombinant Human Growth Hormone (Catalog # 1067-GH) stimulates proliferation in the Nb2‑11 rat lymphoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human Growth Hormone more
Recombinant Human Growth Hormone protein was serially diluted 2-fold and captured by Mouse Anti-Human Growth Hormone Monoclonal Antibody (Catalog # MAB10671) coated on a Clear Polystyrene Microplate (Catalog # more

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IHC, B/N

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Growth Hormone Antibody [Unconjugated] Summary

E. coli-derived recombinant human Growth Hormone
Accession # CAA23779
Detects human Growth Hormone in direct ELISAs and Western blots.
Purity Statement
Antigen Affinity-purified
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Immunohistochemistry 5-15 ug/mL
  • Neutralization 1.5-7.5 ng/mL
  • Western Blot 0.5 ug/mL
Read Publications using
AF1067 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Growth Hormone Antibody [Unconjugated]

  • GH1
  • GHB5
  • GHN
  • GH-N
  • GHNGrowth hormone
  • GH-Nsomatotropin
  • growth hormone 1Pituitary growth hormone
  • Growth Hormone
  • hGH-N
  • IGHD1A
  • IGHD2
  • Somatotropin


Growth Hormone (GH), also known as somatotropin, is a member of a family of growth factors that includes prolactin, placental lactogens, proliferins, and somatolactin (1, 2). It is synthesized primarily by somatotropes in the anterior pituitary and is stored in secretary granules. The pulsatile release of GH into circulation is regulated by the concerted actions of the hypothalamic hormones - GH-releasing hormone (GHRH) and somatostatin (SST) - as well as by signals from the periphery - ghrelin (3) and leptin (4). The human GH cDNA encodes a 217 amino acid (aa) residue precursor protein with a 26 aa putative signal peptide. By alternative splicing, at least four isoforms of GH have been identified (5).

Human GH is a pleiotropic cytokine that exerts its biological actions by binding to the transmembrane GH receptor, which is present in many cell types (1, 2). GH stimulates the liver and other tissues to produce IGF-I, which regulates growth and metabolism. GH has also been shown to have direct effects on growth that is independent of IGF-I. GH, directly or indirectly via IGF-I, can act on B cells, T cells, NK cells, macrophages, and neutrophils to exert immunomodulatory activities (6). In addition, GH can act directly on various cell types to induce lipolysis, lactation, amino acid uptake, and protein synthesis (1, 2, 6).

  1. Goffin, V. et al. (1996) Endocrine Rev. 17:385.
  2. Le Roith, D. et al. (2001) Endocrine Rev. 22:53.
  3. Kojima, K. et al. (1999) Nature, 402:656.
  4. Tannenbaum, G. et al. (1998) Endocrinol. 139:3871.
  5. Welniak, L.A. et al. (2002) J. Leukoc. Biol. 71:381.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Growth Hormone Antibody (AF1067)(9)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 5 applications: Electrochemiluminescent Assay, IHC, IHC-P, Neutralization, Western Blot.

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Electrochemiluminescent Assay
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Showing Publications 1 - 9 of 9.
Publications using AF1067 Applications Species
V Chesnokova, S Zonis, A Apostolou, HQ Estrada, S Knott, K Wawrowsky, K Michelsen, A Ben-Shlomo, R Barrett, V Gorbunova, K Karalis, S Melmed Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage Cell Reports, 2021-12-14;37(11):110068. 2021-12-14 [PMID: 34910915] (Western Blot, Human) Western Blot Human
EJ Vélez, S Unniappan Nesfatin-1 and nesfatin-1-like peptide suppress growth hormone synthesis via the AC/PKA/CREB pathway in mammalian somatotrophs Sci Rep, 2020-10-07;10(1):16686. 2020-10-07 [PMID: 33028951] (Western Blot, Rat) Western Blot Rat
D Abboud, AF Daly, N Dupuis, MA Bahri, A Inoue, A Chevigné, F Ectors, A Plenevaux, B Pirotte, A Beckers, J Hanson GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11 Nat Commun, 2020-09-21;11(1):4752. 2020-09-21 [PMID: 32958754] (IHC, Mouse) IHC Mouse
H Sasanuma, M Nakata, K Parmila, J Nakae, T Yada PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis Mol Metab, 2017-02-17;6(5):428-439. 2017-02-17 [PMID: 28462077] (IHC-P, Mouse) IHC-P Mouse
Growth hormone is permissive for neoplastic colon growth Proc Natl Acad Sci USA, 2016-05-25;0(0):. 2016-05-25 [PMID: 27226307] (Western Blot, Human) Western Blot Human
Zhou , Cuiqi, Jiao , Yonghui, Wang , Renzhi, Ren , Song-Gua, Wawrowsky , Kolja, Melmed , Shlomo STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion. J Clin Invest, 2015-03-16;125(4):1692-702. 2015-03-16 [PMID: 25774503] (Western Blot, Human) Western Blot Human
Myler HA, McVay S, Kratzsch J Troubleshooting PEG-hGH detection supporting pharmacokinetic evaluation in growth hormone deficient patients. J Pharmacol Toxicol Methods, 2010-01-04;61(2):92-7. 2010-01-04 [PMID: 20044010] (Electrochemiluminescent Assay, Human) Electrochemiluminescent Assay Human
Harvey S, Parker E, Macdonald I, Sanders EJ Growth hormone is present in the human retina and vitreous fluid. Neurosci. Lett., 2009-03-27;455(3):199-202. 2009-03-27 [PMID: 19429121] (IHC-P, Western Blot, Human) IHC-P, Western Blot Human
Lange T, Dimitrov S, Fehm HL, Westermann J, Born J Shift of monocyte function toward cellular immunity during sleep. Arch. Intern. Med., 2006-09-18;166(16):1695-700. 2006-09-18 [PMID: 16983046] (Neutralization, Human) Neutralization Human

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Blogs on Growth Hormone.

Growth hormone (GH, somatotropin, hGH, pituitary growth hormone)
GH is a member of the large family of growth factors that includes prolactin, placental lactogens, proliferins, and somatolactin. Additionally, GH is a 191-amino acid, single-chain polypeptide that is synthesized, stored, and secreted by somatotropic ...  Read full blog post.

Somatostatin Receptor 2: Treating Patients Who Cannot Stop Growing
Acromegaly is a rare life-shortening disease caused by elevated levels of growth hormone (GH) secreted by a tumor on the pituitary gland. Treatments include somatostatin analogs, which activate somatostatin receptor 2 (SSTR2), reducing GH secretion an...  Read full blog post.

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Gene Symbol GH1