Tollip Antibody (Kimmy-1)

Product Discontinued

Tollip Antibody (Kimmy-1) Summary

• Immunogen: Recombinant mouse Tollip.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: TOLLIP
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 1:10-1:500
  • Western Blot 5 ug/ml

Reactivity Notes

Human and Mouse

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein G purified

Alternate Names for Tollip Antibody (Kimmy-1)

• adapter protein
• FLJ33531
• IL-1RAcPIP
• toll interacting protein
• toll-interacting protein
• Tollip

Background

TOLLIP is a ubiquitin-binding protein that interacts with several components of the Toll-like receptor (TLR; see MIM 603030) signaling cascade. It is an essential regulator of inflammatory signaling and is involved in trafficking of interleukin-1 receptor (IL1R; MIM 147810) and turnover of IL1R-associated kinase (IRAK, or IRAK1; MIM 300283) (summary by Lo et al., 2009 (PubMed 19444506)).(supplied by OMIM)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Tollip Antibody (NBP1-97636)(2)

Publications using NBP1-97636

• Neumann D, Kollewe C, Pich A et al. Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation. J Leukoc Biol. 2008-09-01 [PMID: 18524972]
• Burns K, Clatworthy J, Martin L et al. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol. 2000-06-01 [PMID: 10854325]

Bioinformatics

• Gene Symbol: TOLLIP