This TLR3 antibody is useful for Western blot, where a band is seen at ~105 kDa.
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read 1 Review rated 5 using NB110-93591 in the following application:
Human, primate, porcine and feline. 92% sequence identity with mouse, rat, equine and bovine
Alternate Names for TLR3 Antibody
toll-like receptor 3
TLR3 (toll-like receptor 3) receptors are a key component of immune system, and represents an intracellular recognition system that specifically respond to RNA viral infections with its unique nucleotide-sensing capability. TLR3 is activated by double-stranded RNAs, and it triggers the production of type 1 IFN as well as inflammatory cytokines/chemokines. TLR3 acts via MYD88/TRAF6 resulting in NFkB activation and cytokine secretion followed by inflammatory response. TLR3 is expressed by epithelial cells, a broad range of antigen-processing cells, tissue dendritic cells, monocytes, mast cells, NK cells etc. TLR3 signaling results in a local cytokine burst which is microenvironment- and cell-specific in nature and leads to local inflammatory response adaptively selected to provide a greatest chance of infection control for affected tissues. TLR3 activation also leads to local production of acute response molecules such as type I IFN, TNF-alpha, IL-12, MCP-1 etc. Defects in TLR3 have been linked to herpes simplex encephalitis type 2 (HSE2) and TLR3 agonists are emerging as promising adjuvants in dendritic cells - based immunotherapy for the treatment of viral and neoplastic diseases.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
The role of TLR4 in breast cancer Toll like receptors (TLRs) are highly conserved proteins that are first known for their role in pathogen recognition and immune response activation. In order to elicit the necessary immune response in reaction to a foreign pathogen, TLRs trigger cy... Read full blog post.