TIRAP (TLR2 and TLR4) Antibody

Immunohistochemistry-Paraffin: TIRAP (TLR2 and TLR4) Antibody [NBP1-39789] - Analysis of anti-TIRAP antibody with human skeletal muscle at concentration 10 ug/ml.

Product Discontinued

TIRAP (TLR2 and TLR4) Antibody Summary

• Immunogen: Synthetic peptide from human TIRAP.
• Specificity: synthetic peptide corresponding to N-terminal residues of human TIRP(Toll/interleukin-1 receptor domain-containing adapter protein)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TIRAP
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1 ug/ml
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 10 ug/ml
  • Western Blot 1 ug/ml

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS and 50% Glycerol
• Preservative: 0.01% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for TIRAP (TLR2 and TLR4) Antibody

• adapter protein wyatt
• Adaptor protein Wyatt
• FLJ42305
• Mal
• MyD88 adapter-like protein
• TIR domain-containing adapter protein
• toll/interleukin-1 receptor domain-containing adapter protein
• toll-interleukin 1 receptor (TIR) domain containing adaptor protein
• Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
• Toll-like receptor adaptor protein
• wyatt

Background

Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NF-kappa B and other signaling pathways through the adapter protein MyD88. All TLRs have a Toll/IL-1 receptor (TIR) domain, which is responsible for signal transduction. MyD88 is one such protein that contains a TIR domain. It acts as an adapter, being involved in TLR-2, TLR-4 and TLR-9 signaling. Toll-interleukin 1 receptor (TIR) domain-containing adapter protein (TIRAP) controls activation of MyD88-independent signaling pathways downstream of TLR4. Double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways (1). It has been demonstrated that TRIF associates with TRAF6 and TBK1 independently, and activates two distinct transcription factors, NF- B and IFN regulatory factor-3, respectively (2). TIRAP is differentially involved in signaling by members of the TLR family and may account for specificity in the downstream signaling of individual TLRs (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TIRAP
• Entrez:
  • 114609(Human)
• Uniprot:
  • P58753(Human)