Applications: WB, ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
Flow, In vitro
Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NF-kappa B and other signaling pathways through the adapter protein MyD88. All TLRs have a Toll/IL-1 receptor (TIR) domain, which is responsible for signal transduction. MyD88 is one such protein that contains a TIR domain. It acts as an adapter, being involved in TLR-2, TLR-4 and TLR-9 signaling. Toll-interleukin 1 receptor (TIR) domain-containing adapter protein (TIRAP) controls activation of MyD88-independent signaling pathways downstream of TLR4. Double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways (1). It has been demonstrated that TRIF associates with TRAF6 and TBK1 independently, and activates two distinct transcription factors, NF- B and IFN regulatory factor-3, respectively (2). TIRAP is differentially involved in signaling by members of the TLR family and may account for specificity in the downstream signaling of individual TLRs (3).
|Product By Gene ID
- TIR domain-containing adapter protein
- Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
- MyD88 adapter-like protein
- toll/interleukin-1 receptor domain-containing adapter protein
- Adaptor protein Wyatt
- Toll-like receptor adaptor protein
- adapter protein wyatt
- toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Bioinformatics Tool for TIRAP (TLR2 and TLR4)
Discover related pathways, diseases and genes to TIRAP (TLR2 and TLR4). Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.