TIRAP (TLR2 and TLR4) Products

Antibodies
TIRAP (TLR2 and TLR4) Antibod ...
TIRAP (TLR2 and TLR4) Antibody
NBP1-39789
Species: Hu
Applications: WB, ELISA, IHC-P
Host: Rabbit Polyclonal
Inhibitors
TIRAP (TLR2 and TLR4) Inhibit ...
TIRAP (TLR2 and TLR4) Inhibitor Pe...
NBP2-26245
Species: Hu, Mu
Applications: Flow, In vitro
TIRAP (TLR2 and TLR4) Inhibit ...
TIRAP (TLR2 and TLR4) Inhibitor Pe...
NBP2-29331
Species: Hu, Mu
Lysates
TIRAP (TLR2 and TLR4) Overexp ...
TIRAP (TLR2 and TLR4) Overexpressi...
NBP2-08583
Species: Hu
Applications: WB
Proteins
Recombinant Human TIRAP (TLR2 ...
Recombinant Human TIRAP (TLR2 and ...
NBP2-22871
Species: Hu
Applications: PAGE

Description

Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NF-kappa B and other signaling pathways through the adapter protein MyD88. All TLRs have a Toll/IL-1 receptor (TIR) domain, which is responsible for signal transduction. MyD88 is one such protein that contains a TIR domain. It acts as an adapter, being involved in TLR-2, TLR-4 and TLR-9 signaling. Toll-interleukin 1 receptor (TIR) domain-containing adapter protein (TIRAP) controls activation of MyD88-independent signaling pathways downstream of TLR4. Double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways (1). It has been demonstrated that TRIF associates with TRAF6 and TBK1 independently, and activates two distinct transcription factors, NF- B and IFN regulatory factor-3, respectively (2). TIRAP is differentially involved in signaling by members of the TLR family and may account for specificity in the downstream signaling of individual TLRs (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 114609
Alternate Names
  • FLJ42305
  • TIR domain-containing adapter protein
  • Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
  • MAL
  • MyD88 adapter-like protein
  • toll/interleukin-1 receptor domain-containing adapter protein
  • Adaptor protein Wyatt
  • Toll-like receptor adaptor protein
  • wyatt
  • adapter protein wyatt
  • Mal
  • toll-interleukin 1 receptor (TIR) domain containing adaptor protein

Research Areas for TIRAP (TLR2 and TLR4)

Find related products by research area and learn more about each of the different research areas below.

Immunology
Innate Immunity
Prostate Cancer

PTMs for TIRAP (TLR2 and TLR4)

Learn more about PTMs related to TIRAP (TLR2 and TLR4).

Phosphorylation
Cleavage
Ubiquitination
Reduction
Methylation
Nitrosylation
Glycosylation
Deacetylation
Acylation
Myristoylation

Bioinformatics Tool for TIRAP (TLR2 and TLR4)

Discover related pathways, diseases and genes to TIRAP (TLR2 and TLR4). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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