DNER Antibody [Unconjugated] Summary
Mouse myeloma cell line NS0-derived recombinant mouse DNER
Ala26-His637 Accession # Q8JZM4
Detects mouse DNER in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 40% cross-reactivity with recombinant human DNER is observed.
Test in a species/application not listed above to receive a full credit towards a future purchase.
Immunohistochemistry 5-15 ug/mL Western Blot 0.1 ug/mL
Packaging, Storage & Formulations
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitute at 0.2 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for DNER Antibody [Unconjugated]
bet delta and Notch-like epidermal growth factor-related receptor delta/notch-like EGF repeat containing delta-notch-like EGF repeat-containing transmembrane DNER H_NH0150O02.1 UNQ26 WUGSC:H_NH0150O02.1 Background
DNER, also known as BET, is a type I transmembrane glycoprotein that is specifically expressed on nonaxonal areas of post-mitotic neurons. The protein has an extracellular domain containing ten distinct EGF-like repeats similar to those found on Delta and Notch. Human and mouse DNER share 90% amino acid sequence identity.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
for 1 year from date of receipt.
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Publications for DNER Antibody (AF2254)(6)
We have publications tested in 3 confirmed species: Human, Mouse, Chicken.
We have publications tested in 5 applications: ICC, IHC, IHC-Fr, IHC-P, Western Blot.
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Showing Publications 1 -
Publications using AF2254
YT Shue, AP Drainas, NY Li, SM Pearsall, D Morgan, N Sinnott-Ar, SQ Hipkins, GL Coles, JS Lim, AE Oro, KL Simpson, C Dive, J Sage A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs Nature Communications, 2022;13(1):2690. 2022 [PMID: 35577801] (IHC, Mouse) IHC
M Marino, L Zhou, MY Rincon, Z Callaerts-, J Verhaert, J Wahis, E Creemers, L Yshii, K Wierda, T Saito, C Marneffe, I Voytyuk, Y Wouters, M Dewilde, SI Duqué, C Vincke, Y Levites, TE Golde, TC Saido, S Muylderman, A Liston, B De Stroope, MG Holt AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model Embo Molecular Medicine, 2022;14(4):e09824. 2022 [PMID: 35352880] (Western Blot, Human) Western Blot
C Ballester-, TM Conlon, Z Ertüz, FR Greiffo, M Irmler, SE Verleden, J Beckers, IE Fernandez, O Eickelberg, AÖ Yildirim The Notch ligand DNER regulates macrophage IFN? release in chronic obstructive pulmonary disease EBioMedicine, 2019;0(0):. 2019 [PMID: 31060902] (IHC-P, Mouse) IHC-P
J Du, X Wang, X Zhang, X Zhang, H Jiang DNER modulates the length, polarity and synaptogenesis of spiral ganglion neurons via the Notch signaling pathway Mol Med Rep, 2018;17(2):2357-2365. 2018 [PMID: 29207144] (Western Blot, Mouse) Western Blot
Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand PLoS ONE, 2016;11(9):e0161157. 2016 [PMID: 27622512] (ICC, Human) ICC
Kowalik L, Hudspeth AJ A search for factors specifying tonotopy implicates DNER in hair-cell development in the chick's cochlea. Dev. Biol., 2011;354(2):221-31. 2011 [PMID: 21497156] (IHC-Fr, Chicken) IHC-Fr
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