TET1 Antibody [DyLight 488]


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Product Details

Reactivity MuSpecies Glossary
Applications IHC, IHC-P, ICC/IF (-), WB (-)
Please see the vial label for concentration. If unlisted please contact technical services.

TET1 Antibody [DyLight 488] Summary

A synthetic peptide made to an internal portion of the human TET1 protein (between residues 170-800) [UniProt Q8NFU7]
Nucleus and cytoplasm.
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C in the dark.
DyLight 488
DyLight 488 (A=493, E=518)
50mM Sodium Borate
0.05% Sodium Azide
Immunogen affinity purified


  • ICC/IF (Negative)
  • Western Blot (Negative)
  • Immunohistochemistry 1:400
  • Immunohistochemistry-Paraffin 1:400
Application Notes
This TET1 antibody is useful for Immunohistochemistry on paraffin embedded sections where staining is observed in the nucleus and cytoplasm of mouse spleen tissue. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. This antibody is not applicable for ICC/IF or Western Blot.

Reactivity Notes


Alternate Names for TET1 Antibody [DyLight 488]

  • bA119F7.1
  • CXXC finger 6
  • CXXC6
  • CXXC6FLJ10839
  • FLJ41442
  • KIAA1676CXXC-type zinc finger protein 6
  • LCX
  • LCXEC 1.14.11.n2
  • Leukemia-associated protein with a CXXC domain
  • methylcytosine dioxygenase TET1
  • Ten-eleven translocation 1 gene protein
  • ten-eleven translocation-1
  • tet oncogene 1


TET1 (Tet methylcytosine dioxygenase 1, LCX, CXXC6) is a member of a novel protein family. This family of proteins may play a role in epigenetic regulation via modification of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). TET1 is a fusion partner of the MLL gene in acute myeloid leukemia (PMID: 19372391). It has been shown that TET1 supports DNA demethylation in mammalian cells via the base excision repair pathway where TET1 converts 5mC to hmC. Additionally, TET1 is integral to neuronal activity-induced, region specific, active DNA demethylation and subsequent gene expression in the dentate gyrus of the adult mouse brain in vivo. This suggests that the mechanism for active DNA demethylation in mammals is through TET1-induced oxidation-deamination (PMID: 21496894).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies


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Contact Information

Product PDFs


Gene Symbol TET1

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