HepG2 human hepatocellular carcinoma cell line was stained with Mouse Anti-Human Serpin A5 Monoclonal Antibody (Catalog # MAB1266, filled histogram) or isotype control antibody (MAB003, open histogram), followed by ...read more
Serpin A5/Protein C Inhibitor Antibody (210326) [Unconjugated] Summary
Mouse myeloma cell line NS0-derived recombinant human Serpin A5/Protein C His20-Pro406 Accession # P05154
Detects human Serpin A5/Protein C in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human Serpin A1, A3, F2, C1, or recombinant mouse Serpin A5 is observed.
Protein A or G purified from hybridoma culture supernatant
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Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitute at 0.5 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Serpin A5/Protein C Inhibitor Antibody (210326) [Unconjugated]
Acrosomal serine protease inhibitor
antitrypsin), member 5
PCIplasminogen activator inhibitor III
Plasminogen activator inhibitor 3
plasminogen activator inhibitor-3
PROCIplasma serine protease inhibitor
Protein C inhibitor
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)
Serpin A5 is the a member of the Serpin superfamily and inhibits a variety of serine proteases such as protein C, plasminogen activators, thrombin, factor Xa, several kallekreins and acrosin (1). Serpin A5 is synthesized in the liver and secreted in plasma. It is found in numerous steroid-responsive organs and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. Because of its protease targets and regulated expression patterns, Serpin A5 has been proposed to play a role in processes such as blood coagulation, fertilization and carcinogenesis (2, 3). Similar to Serpins C1 and D1, its thrombin inhibitory activity is enhanced by heparin.
Silverman, G.A. et al. (2001) J. Biol. Chem. 276:33293.
Palmier, D. et al. (2002) J. Biol. Chem. 277:40950.
Geiger, M. et al. (1996) Immunopharmacology 32:53.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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